Folate deficiency classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Some situations that increase the need for folate may lead to folate deficiency in the body. These include: Hemorrhage, kidney dialysis, liver disease, malabsorption e.g. celiac disease, pregnancy and lactation, and alcohol consumption. Some medications and Some congenital disorders can also lead to folate deficiency.

Classification

Folate deficiency can be classified as follows :

Situational

Some situations that increase the need for folate may lead to folate deficiency in the body. These include:

• Hemorrhage
• Kidney dialysis
• Liver disease
• Malabsorption e.g. celiac disease
• Pregnancy and lactation
• Alcohol consumption

Medication

Medications can interfere with folate utilization, including:

• Anticonvulsant medications e.g phenytoin
• Metformin 
• Methotrexate, an anti-cancer drug also used as an anti-inflammatory
• Sulfasalazine, used in Inflammatory bowel syndrome
• Birth control pills

Congenital

• Defects in folate metabolism
• Defects in folate absorption

There is no established system for the classification of [disease name].

OR

[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].

OR

[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].

OR

Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.