Cervical cancer causes: Difference between revisions
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==Overview== | ==Overview== | ||
Cervical cancer is caused by an infection with [[Human papillomavirus]]. | Cervical cancer is caused by an infection with [[Human papillomavirus]], which is transmitted mainly by skin to skin contact. Only high risk strains of HPV are causing cervical cancer, having multiple sexual partner is risk factor for infecting with HPV. | ||
==Causes== | ==Causes== | ||
[[Human papillomavirus]] | [[Human papillomavirus]] is main cause of cervical cancer, only high-risk HPV types are the ones can affect squamous epithelium of cervix and cause cancer, these strains include types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70. HPV genes product interfere with cell cycle control and leads to abnormal growth of epithelial cells of cervix which leads to neoplasia. The assosiciation between HPV infection and glandular type of cervical neoplasia is less strong than that of squamous carcinoma of cervix. HPV is a small, nonenveloped DNA virus, 55 nm in diameter, transmits primarily by skin to skin contact. <ref name="pmid12525422">{{cite journal |vauthors=Burd EM |title=Human papillomavirus and cervical cancer |journal=Clin. Microbiol. Rev. |volume=16 |issue=1 |pages=1–17 |date=January 2003 |pmid=12525422 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 14:25, 11 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]Monalisa Dmello, M.B,B.S., M.D. [3]
Overview
Cervical cancer is caused by an infection with Human papillomavirus, which is transmitted mainly by skin to skin contact. Only high risk strains of HPV are causing cervical cancer, having multiple sexual partner is risk factor for infecting with HPV.
Causes
Human papillomavirus is main cause of cervical cancer, only high-risk HPV types are the ones can affect squamous epithelium of cervix and cause cancer, these strains include types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70. HPV genes product interfere with cell cycle control and leads to abnormal growth of epithelial cells of cervix which leads to neoplasia. The assosiciation between HPV infection and glandular type of cervical neoplasia is less strong than that of squamous carcinoma of cervix. HPV is a small, nonenveloped DNA virus, 55 nm in diameter, transmits primarily by skin to skin contact. [1]