Neck of femur fracture pathophysiology: Difference between revisions
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===Anatomy=== | ===Anatomy=== | ||
==References== | |||
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[[Category: Orthopedics]] | |||
[[Category: Orthopedic surgery]] | |||
[[Category: Fractures]] | |||
[[Category: Bone Fractures]] | |||
[[Category: Up-To-Date]] | |||
Revision as of 16:03, 11 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]
Overview
The pattern of fracture and degree of comminution are the resultant of several factors or variables such as the nature of injury, the bone quality, the age and weight of the patient, the energy involved, and the position of the hip and leg at the time of impact. Various combinations of these variables lead to a variety of different fracture patterns.
Pathophysiology
- The fracture pattern and severity of comminution depends on multiple factors including:[1]
- Decrease in bone mass density involves following process:[2]
- Autophagy is the mechanism through which osteocytes evade oxidative stress.
- The capability of autophagy in cells decreases as they age, a major factor of aging.
- As osteocytes grow, viability of cells decrease thereby decreasing the bone mass density.
Anatomy
References
- ↑ Azar, Frederick (2017). Campbell's operative orthopaedics. Philadelphia, PA: Elsevier. ISBN 9780323374620.
- ↑ Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S; et al. (2013). "Suppression of autophagy in osteocytes mimics skeletal aging". J Biol Chem. 288 (24): 17432–40. doi:10.1074/jbc.M112.444190. PMC 3682543. PMID 23645674.