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==Overview==
==Overview==
* In 1910, the term neuroblastoma was first used to describe the tumor by Dr. James Homer Wright, an American patholgist at Massachusetts General Hospital.<ref name="wiki">Neuroblastoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 4 2015</ref>
 


==Historical Perspective==
==Historical Perspective==
* Neuroblastoma was first discovered by Dr. Rudolf Virchow, a German physician, in 1864.<ref name="wiki">Neuroblastoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 4 2015</ref>
* In 1864, Rudolf Virchow (german physician) first described an abdominal tumor in a child as "glioma".
* Neuroblastoma was first noted to originate from the sympathetic nervous system and the adrenal medulla by Dr. Felix Marchand, a German pathologist, in 1891.
* In 1891, Felix Marchand (german pathologist) described the characteristics of tumors from adrenal medulla and sympathetic nervous system.
* In 1910, the term neuroblastoma was first used to describe the tumor by Dr. James Homer Wright, an American patholgist at Massachusetts General Hospital.
* In 1901, William Pepper described a neuroblastoma stage 4S presentation in infants that was metastatic to liver.
* The presence of pseudorosettes on bone marrow samples of neuroblastoma patients was first described by Dr. James Homer Wright. This characteristic histological finding is now termed "Homer-Wright pseudorosettes".
* In 1910, James Homer Wright described circular clumps of cells in bone marrow ( now named "Homer-Wright pseudorosettes) and advanced the understanding that tumor originated from primitive neural cells and could metastasize to bone.


==References==
==References==

Revision as of 16:33, 12 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Overview

Historical Perspective

  • In 1864, Rudolf Virchow (german physician) first described an abdominal tumor in a child as "glioma".
  • In 1891, Felix Marchand (german pathologist) described the characteristics of tumors from adrenal medulla and sympathetic nervous system.
  • In 1901, William Pepper described a neuroblastoma stage 4S presentation in infants that was metastatic to liver.
  • In 1910, James Homer Wright described circular clumps of cells in bone marrow ( now named "Homer-Wright pseudorosettes) and advanced the understanding that tumor originated from primitive neural cells and could metastasize to bone.

References


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