Multiple sclerosis laboratory findings: Difference between revisions
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==== CSF analysis: ==== | ==== CSF analysis: ==== | ||
* An elevated concentration of [[CSF]] [[oligoclonal bands]] is [[diagnostic]] of multiple sclerosis and can be seen in more than 95% of these patients. [[Oligoclonal bands]] are an indicator of disease progression. [[CSF]] analysis is mostly used to rule out other [[differential diagnosis]] of [[MS]] since it’s not needed in [[MS]] patients who have typical clinical presentation and [[MRI]] findings.<ref name="pmid11456302">{{cite journal |vauthors=McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS |title=Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis |journal=Ann. Neurol. |volume=50 |issue=1 |pages=121–7 |date=July 2001 |pmid=11456302 |doi= |url=}}</ref><ref name="pmid2245296">{{cite journal |vauthors=McLean BN, Luxton RW, Thompson EJ |title=A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the Log IgG-Index. A comparison and diagnostic applications |journal=Brain |volume=113 ( Pt 5) |issue= |pages=1269–89 |date=October 1990 |pmid=2245296 |doi= |url=}}</ref><ref name="pmid23431079">{{cite journal |vauthors=Dobson R, Ramagopalan S, Davis A, Giovannoni G |title=Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude |journal=J. Neurol. Neurosurg. Psychiatry |volume=84 |issue=8 |pages=909–14 |date=August 2013 |pmid=23431079 |doi=10.1136/jnnp-2012-304695 |url=}}</ref> | * An elevated concentration of [[CSF]] [[oligoclonal bands]] is [[diagnostic]] of multiple sclerosis and can be seen in more than 95% of these patients. | ||
* [[Oligoclonal bands]] are an indicator of disease progression. | |||
* [[CSF]] analysis is mostly used to rule out other [[differential diagnosis]] of [[MS]] since it’s not needed in [[MS]] patients who have typical clinical presentation and [[MRI]] findings.<ref name="pmid11456302">{{cite journal |vauthors=McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS |title=Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis |journal=Ann. Neurol. |volume=50 |issue=1 |pages=121–7 |date=July 2001 |pmid=11456302 |doi= |url=}}</ref><ref name="pmid2245296">{{cite journal |vauthors=McLean BN, Luxton RW, Thompson EJ |title=A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the Log IgG-Index. A comparison and diagnostic applications |journal=Brain |volume=113 ( Pt 5) |issue= |pages=1269–89 |date=October 1990 |pmid=2245296 |doi= |url=}}</ref><ref name="pmid23431079">{{cite journal |vauthors=Dobson R, Ramagopalan S, Davis A, Giovannoni G |title=Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude |journal=J. Neurol. Neurosurg. Psychiatry |volume=84 |issue=8 |pages=909–14 |date=August 2013 |pmid=23431079 |doi=10.1136/jnnp-2012-304695 |url=}}</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.
Overview
An elevated concentration of CSF oligoclonal bands is diagnostic of multiple sclerosis.
Laboratory Findings
CSF analysis:
- An elevated concentration of CSF oligoclonal bands is diagnostic of multiple sclerosis and can be seen in more than 95% of these patients.
- Oligoclonal bands are an indicator of disease progression.
- CSF analysis is mostly used to rule out other differential diagnosis of MS since it’s not needed in MS patients who have typical clinical presentation and MRI findings.[1][2][3]
References
- ↑ McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS (July 2001). "Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis". Ann. Neurol. 50 (1): 121–7. PMID 11456302.
- ↑ McLean BN, Luxton RW, Thompson EJ (October 1990). "A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the Log IgG-Index. A comparison and diagnostic applications". Brain. 113 ( Pt 5): 1269–89. PMID 2245296.
- ↑ Dobson R, Ramagopalan S, Davis A, Giovannoni G (August 2013). "Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude". J. Neurol. Neurosurg. Psychiatry. 84 (8): 909–14. doi:10.1136/jnnp-2012-304695. PMID 23431079.