Glioblastoma multiforme classification: Difference between revisions
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==Overview== | ==Overview== | ||
Glioblastoma multiforme may be classified into several subtypes based on the origin (primary and secondary) and molecular alterations (classic, proneural, mesenchymal, and neural).<ref name=ddd>Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma</ref><ref name="pmid20129251">{{cite journal| author=Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al.| title=Integrated genomic analysis identifies clinically relevant subtypes of Glioblastoma multiforme characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. | journal=Cancer Cell | year= 2010 | volume= 17 | issue= 1 | pages= 98-110 | pmid=20129251 | doi=10.1016/j.ccr.2009.12.020 | pmc=PMC2818769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20129251 }} </ref> | Glioblastoma multiforme may be classified into several subtypes based on the origin (primary and secondary) and molecular alterations (classic, proneural, mesenchymal, and neural).<ref name="ddd">Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma</ref><ref name="pmid20129251">{{cite journal| author=Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al.| title=Integrated genomic analysis identifies clinically relevant subtypes of Glioblastoma multiforme characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. | journal=Cancer Cell | year= 2010 | volume= 17 | issue= 1 | pages= 98-110 | pmid=20129251 | doi=10.1016/j.ccr.2009.12.020 | pmc=PMC2818769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20129251 }} </ref> | ||
==Classification== | ==Classification== | ||
===Based on the origin=== | ===Based on the origin=== | ||
Glioblastoma multiforme may be classified according to the origin into two subtypes: Primary and secondary.<ref name=ddd>Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma</ref> | Glioblastoma multiforme may be classified according to the origin into two subtypes: Primary and secondary.<ref name="ddd">Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma</ref> | ||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Subtype of Glioblastoma multiforme}} | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Subtype of Glioblastoma multiforme}} | ||
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*Occurs in younger patients | *Occurs in younger patients | ||
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* Primary and secondary forms show some molecular differences. | |||
* The end result of both sub type is same since the same pathways are affected and respond similarly to current standard treatment. | |||
===Based on the molecular alterations=== | ===Based on the molecular alterations=== | ||
Revision as of 18:08, 19 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]
Overview
Glioblastoma multiforme may be classified into several subtypes based on the origin (primary and secondary) and molecular alterations (classic, proneural, mesenchymal, and neural).[1][2]
Classification
Based on the origin
Glioblastoma multiforme may be classified according to the origin into two subtypes: Primary and secondary.[1]
| Subtype of Glioblastoma multiforme | Characteristic features |
|---|---|
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- Primary and secondary forms show some molecular differences.
- The end result of both sub type is same since the same pathways are affected and respond similarly to current standard treatment.
Based on the molecular alterations
Glioblastoma multiforme may be classified according to the molecular alterations into four subtypes:[2]
- Classic
- Proneural
- Mesenchymal
- Neural
References
- ↑ 1.0 1.1 Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma
- ↑ 2.0 2.1 Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD; et al. (2010). "Integrated genomic analysis identifies clinically relevant subtypes of Glioblastoma multiforme characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. PMC 2818769. PMID 20129251.