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==Classification==
==Classification==
Testicular cancer may be classified according to WHO classification into two subtypes:<ref name="pmid27747907">{{cite journal |vauthors=Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM |title=The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel |journal=Histopathology |volume=70 |issue=3 |pages=335–346 |date=February 2017 |pmid=27747907 |doi=10.1111/his.13102 |url=}}</ref><ref name="pmid26935559">{{cite journal |vauthors=Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM |title=The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours |journal=Eur. Urol. |volume=70 |issue=1 |pages=93–105 |date=July 2016 |pmid=26935559 |doi=10.1016/j.eururo.2016.02.029 |url=}}</ref>
=== WHO Classification of testicular Tumors ===
'''WHO''' classifies testicular tumors as follows:<ref name="pmid27747907">{{cite journal |vauthors=Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM |title=The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel |journal=Histopathology |volume=70 |issue=3 |pages=335–346 |date=February 2017 |pmid=27747907 |doi=10.1111/his.13102 |url=}}</ref><ref name="pmid26935559">{{cite journal |vauthors=Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM |title=The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours |journal=Eur. Urol. |volume=70 |issue=1 |pages=93–105 |date=July 2016 |pmid=26935559 |doi=10.1016/j.eururo.2016.02.029 |url=}}</ref>
{| class="wikitable"
|+
 
! colspan="6" style="background:#4479BA; color: #FFFFFF;" align="center" + |Testicular Cancer
|-
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Germ cell tumors
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Sex-cord stromal tumors
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Tumors containing both germ cell and sex-cord stromal elements
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Miscellaneous tumors of the testis
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Hematolymphoid tumors
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Tumors of collecting duct and rete testis
|-
|
* '''Serous tumors:'''
** Benign (cystadenoma)
** Borderline tumors (serous borderline tumor)
** Malignant (serous adenocarcinoma)
* '''Mucinous tumors:'''
** Benign (cystadenoma)
** Borderline tumors (mucinous borderline tumor)
** Malignant (mucinous adenocarcinoma)
* '''Endometrioid tumors:'''
** Benign (cystadenoma)
** Borderline tumors (endometrioid borderline tumor)
** Malignant (endometrioid adenocarcinoma)
* '''Clear cell tumors:'''
** Benign
** Borderline tumors
** Malignant (clear cell adenocarcinoma)
* '''Transitional cell tumors:'''
** Brenner tumor
** Brenner tumor of borderline malignancy
** Malignant Brenner tumor
** Transitional cell carcinoma (non-Brenner type)
* '''Epithelial-stromal:'''
** Adenosarcoma
** Carcinosarcoma (formerly mixed Müllerian tumors)
|
* '''Pure stromal tumors:'''
** Fibroma
** Cellular fibroma
** Thecoma
** Luteinized thecoma associated with sclerosing peritonitis
** Fibrosarcoma
** Sclerosing stromal tumor
** Signet-ring stromal tumor
** Microcystic stromal tumor
** Leydig cell tumor
** Steroid cell tumor
** Steroid cell tumor, malignant
* '''Pure sex cord tumors:'''
** Adult granulosa cell tumor
** Juvenile granulosa cell tumor
** Sertoli cell tumor
** Sex cord tumor with annular tubules
* '''Mixed sex cord-stromal''' '''tumors'''
** Sertoli-Leydig cell tumors
*** - Well-differentiated
*** - Moderately differentiated with heterologous elements
*** - Poorly differentiated with heterologous elements
*** - Retiform with heterologous elements
** Sex cord-stromal tumours, NOS*
*
 
*
|
* '''Teratoma'''
** Immature
** Mature
** Solid
** Cystic (dermoid cyst)
* '''Dysgerminoma'''
* '''Endometrial Sinus tumors'''
* '''Embryonal carcinoma'''
* '''Polyembryoma'''
* '''Choriocarcinoma'''
* '''Mixed germ cell tumors tumors'''
|
* '''Gonadoblastoma'''
* '''Germ cell sex cord-stromal tumor of nongonadoblastoma type'''
* '''Tumors of rete ovarii'''
* '''Mesothelial tumors'''
* '''Tumors of uncertain origin and miscellaneous tumors'''
* '''Gestational trophoblastic diseases'''
* '''Soft tissue tumors not specific to ovary'''
* '''Malignant lymphomas leukemias, and plasmacytomas'''
* '''Unclassified tumors'''
* '''Secondary (metastatic) tumors'''
* '''Tumor-like lesions'''
|}
Testicular cancer may be classified according to WHO classification into two subtypes:
* [[Germ cell tumors]]
* [[Germ cell tumors]]
:*[[Germ cell neoplasia]] in situ-derived
:*[[Germ cell neoplasia]] in situ-derived

Revision as of 16:30, 20 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Overview

Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into two subtypes: germ cell tumors and non–germ cell tumors.

Classification

WHO Classification of testicular Tumors

WHO classifies testicular tumors as follows:[1][2]

Testicular Cancer
Germ cell tumors Sex-cord stromal tumors Tumors containing both germ cell and sex-cord stromal elements Miscellaneous tumors of the testis Hematolymphoid tumors Tumors of collecting duct and rete testis
  • Serous tumors:
    • Benign (cystadenoma)
    • Borderline tumors (serous borderline tumor)
    • Malignant (serous adenocarcinoma)
  • Mucinous tumors:
    • Benign (cystadenoma)
    • Borderline tumors (mucinous borderline tumor)
    • Malignant (mucinous adenocarcinoma)
  • Endometrioid tumors:
    • Benign (cystadenoma)
    • Borderline tumors (endometrioid borderline tumor)
    • Malignant (endometrioid adenocarcinoma)
  • Clear cell tumors:
    • Benign
    • Borderline tumors
    • Malignant (clear cell adenocarcinoma)
  • Transitional cell tumors:
    • Brenner tumor
    • Brenner tumor of borderline malignancy
    • Malignant Brenner tumor
    • Transitional cell carcinoma (non-Brenner type)
  • Epithelial-stromal:
    • Adenosarcoma
    • Carcinosarcoma (formerly mixed Müllerian tumors)
  • Pure stromal tumors:
    • Fibroma
    • Cellular fibroma
    • Thecoma
    • Luteinized thecoma associated with sclerosing peritonitis
    • Fibrosarcoma
    • Sclerosing stromal tumor
    • Signet-ring stromal tumor
    • Microcystic stromal tumor
    • Leydig cell tumor
    • Steroid cell tumor
    • Steroid cell tumor, malignant
  • Pure sex cord tumors:
    • Adult granulosa cell tumor
    • Juvenile granulosa cell tumor
    • Sertoli cell tumor
    • Sex cord tumor with annular tubules
  • Mixed sex cord-stromal tumors
    • Sertoli-Leydig cell tumors
      • - Well-differentiated
      • - Moderately differentiated with heterologous elements
      • - Poorly differentiated with heterologous elements
      • - Retiform with heterologous elements
    • Sex cord-stromal tumours, NOS*
  • Teratoma
    • Immature
    • Mature
    • Solid
    • Cystic (dermoid cyst)
  • Dysgerminoma
  • Endometrial Sinus tumors
  • Embryonal carcinoma
  • Polyembryoma
  • Choriocarcinoma
  • Mixed germ cell tumors tumors
  • Gonadoblastoma
  • Germ cell sex cord-stromal tumor of nongonadoblastoma type
  • Tumors of rete ovarii
  • Mesothelial tumors
  • Tumors of uncertain origin and miscellaneous tumors
  • Gestational trophoblastic diseases
  • Soft tissue tumors not specific to ovary
  • Malignant lymphomas leukemias, and plasmacytomas
  • Unclassified tumors
  • Secondary (metastatic) tumors
  • Tumor-like lesions

Testicular cancer may be classified according to WHO classification into two subtypes:

  • Seminomas
  • Non-seminomas
  • Non–germ cell tumors
  • Other tumors

References

  1. ↑ Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.
  2. ↑ Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.


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