Testicular cancer classification: Difference between revisions

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Revision as of 20:31, 20 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Overview

Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into two subtypes: germ cell tumors and non–germ cell tumors.

Classification

WHO Classification of testicular Tumors

WHO classifies testicular tumors as follows:^[1]^[2]


Testicular Cancer
Germ cell tumors	Sex-cord stromal tumors	Tumors containing both germ cell and sex-cord stromal elements	Miscellaneous tumors of the testis	Hematolymphoid tumors	Tumors of collecting duct and rete testis
Germ cell tumors derived from germ cell neoplasia in situ: Non-invasive germ cell neoplasia Germ cell neoplasia in situ Specific forms of intratubular germ cell tumor neoplasia Tumors of a single histological type (pure forms) Seminoma Seminoma with syncytiotrophoblast cells Non-seminomatous germ cell tumors Embryonal carcinoma York sac tumor, postpubertal-type Trophoblastic tumors Choriocarcinoma Non-choriocarcinomatous trophoblastic tumors Placental site trophoblastic tumor Epitheliol trophoblastic tumor Cystic trophoblastic tumor Teratoma, postpubertal-type Teratoma with somatic-type malignancy Non-seminomatous germ cell type tumor of more than one histological type Mixed germ cell tumors Germ cell tumors of unknown type Regressed germ cell tumors Germ cell tumors unrelated to germ cell neoplasia in situ: Spermatocytic tumor Teratoma, prepubertal-type Dermoid cyst Epidermoid cyst Well-differentiated neuroendocrine tumor (monodermal teratoma) Mixed teratoma and yolk sac tumor, prepubertal-type Yolk sac tumor, prepubertal-type	Pure tumors Leydig cell tumor Malignant leydig cell tumor Sertoli cell tumor Malignant Sertoli cell tumor Large cell calcifying Sertoli cell tumor Intratubular large cell hyalinizing Sertoli cell neoplasia Granulosa cell tumor Adult granulosa cell tumor Juvenile granulosa cell tumor Tumors in the fibroma-thecoma group Mixed and unclassified sex-stromal tumors Mixed sex cord-stromal tumor Unclassified sex cord-stromal tumor	Teratoma Immature Mature Solid Cystic (dermoid cyst) Dysgerminoma Endometrial Sinus tumors Embryonal carcinoma Polyembryoma Choriocarcinoma Mixed germ cell tumors tumors	Gonadoblastoma Germ cell sex cord-stromal tumor of nongonadoblastoma type Tumors of rete ovarii Mesothelial tumors Tumors of uncertain origin and miscellaneous tumors Gestational trophoblastic diseases Soft tissue tumors not specific to ovary Malignant lymphomas leukemias, and plasmacytomas Unclassified tumors Secondary (metastatic) tumors Tumor-like lesions

Testicular cancer may be classified according to WHO classification into two subtypes:

Germ cell tumors

Germ cell neoplasia in situ-derived

Seminomas
Non-seminomas

Choriocarcinoma
Other trophoblastic tumors

Teratoma, postpubertal type

Somatic malignant

Not germ cell neoplasia in situ-derived

Non–germ cell tumors

Sex cord stromal tumors

Mixed germ cell and stromal tumors

Gonadoblastoma

Adnexal and paratesticular tumors

Adenocarcinoma of the rete testis
Adenocarcinoma of the epididymis
Malignant mesothelioma

Other tumors

References

↑ Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.
↑ Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.

Template:WikiDoc Sources

[pmid27747907-1] Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.

[pmid26935559-2] Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.

[1]

[2]

@@ Line 62: / Line 62: @@
 ***Adult granulosa cell tumor
 ***Juvenile granulosa cell tumor
-** Steroid cell tumor
+**Tumors in the fibroma-thecoma group
-** Steroid cell tumor, malignant
+**Mixed and unclassified sex-stromal tumors
-* '''Pure sex cord tumors:'''
+**Mixed sex cord-stromal tumor
-** Adult granulosa cell tumor
+**Unclassified sex cord-stromal tumor
-** Juvenile granulosa cell tumor
-** Sertoli cell tumor
-** Sex cord tumor with annular tubules
-* '''Mixed sex cord-stromal''' '''tumors'''
-** Sertoli-Leydig cell tumors
-*** - Well-differentiated
-*** - Moderately differentiated with heterologous elements
-*** - Poorly differentiated with heterologous elements
-*** - Retiform with heterologous elements
-** Sex cord-stromal tumours, NOS*
 *