Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into two subtypes: germ cell tumors and non–germ cell tumors.
Classification
WHO Classification of testicular Tumors
WHO classifies testicular tumors as follows:[1][2]
Testicular Cancer
Germ cell tumors
Sex-cord stromal tumors
Tumors containing both germ cell and sex-cord stromal elements
Miscellaneous tumors of the testis
Hematolymphoid tumors
Tumors of collecting duct and rete testis
Germ cell tumors derived from germ cell neoplasia in situ:
Non-invasive germ cell neoplasia
Germ cell neoplasia in situ
Specific forms of intratubular germ cell tumor neoplasia
Tumors of a single histological type (pure forms)
Seminoma
Seminoma with syncytiotrophoblast cells
Non-seminomatous germ cell tumors
Embryonal carcinoma
York sac tumor, postpubertal-type
Trophoblastic tumors
Choriocarcinoma
Non-choriocarcinomatous trophoblastic tumors
Placental site trophoblastic tumor
Epitheliol trophoblastic tumor
Cystic trophoblastic tumor
Teratoma, postpubertal-type
Teratoma with somatic-type malignancy
Non-seminomatous germ cell type tumor of more than one histological type
Mixed germ cell tumors
Germ cell tumors of unknown type
Regressed germ cell tumors
Germ cell tumors unrelated to germ cell neoplasia in situ:
Mixed teratoma and yolk sac tumor, prepubertal-type
Yolk sac tumor, prepubertal-type
Pure tumors
Leydig cell tumor
Malignant leydig cell tumor
Sertoli cell tumor
Malignant Sertoli cell tumor
Large cell calcifying Sertoli cell tumor
Intratubular large cell hyalinizing Sertoli cell neoplasia
Granulosa cell tumor
Adult granulosa cell tumor
Juvenile granulosa cell tumor
Tumors in the fibroma-thecoma group
Mixed and unclassified sex-stromal tumors
Mixed sex cord-stromal tumor
Unclassified sex cord-stromal tumor
Gonadoblastoma
Ovarian epithelial-type tumors
Serous cystadenoma
Serous tumor of borderline malignancy
Serous cystadenocarcinoma
Mucinous borderline tumor
Mucinous cystadenocarcinoma
Endometrioid adenocarcinoma
Clear cell adenocarcinoma
Brenner tumor
Juvenile Xanthogranuloma
Hemangioma
Diffuse large B-cell lymphoma
Follicular lymphoma, NOS
Extranodal NK/T-cell lymphoma, nasal type
Plasmacytoma
Myeloid sarcoma
Rosai-Dorfman disease
Adenoma
Adenocarcinoma
References
↑Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID27747907.
↑Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID26935559.