Leiomyosarcoma surgery: Difference between revisions
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==Surgery== | ==Surgery== | ||
* Surgery | * Surgery is mainstay of therapy in leiomyosarcoma patients, in case of recurrence or progression of disease combination therapy with chemoradiation can be used as well. <ref name="pmid17338203">{{cite journal |vauthors=Vrzic-Petronijevic S, Likic-Ladjevic I, Petronijevic M, Argirovic R, Ladjevic N |title=Diagnosis and surgical therapy of uterine sarcoma |journal=Acta Chir Iugosl |volume=53 |issue=3 |pages=67–72 |date=2006 |pmid=17338203 |doi= |url=}}</ref> | ||
* Hysterectomy with bilateral salpingooophorectomy has been the main effective way of surgical therapy in patients with leiomyosarcoma. | |||
* Lymphadenectomy is generally not required as the tumor usually metastasize hematogenously and rarely through the lymph nodes.<ref name="pmid18506484">Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18506484 Prognostic factors and treatment outcomes of patients with uterine sarcoma: analysis of 127 patients at a single institution, 1989-2007.] ''J Cancer Res Clin Oncol'' 134 (12):1277-87. [http://dx.doi.org/10.1007/s00432-008-0422-2 DOI:10.1007/s00432-008-0422-2] PMID: [https://pubmed.gov/18506484 18506484]</ref><ref name="pmid14529683">Leitao MM, Sonoda Y, Brennan MF, Barakat RR, Chi DS (2003) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=14529683 Incidence of lymph node and ovarian metastases in leiomyosarcoma of the uterus.] ''Gynecol Oncol'' 91 (1):209-12. PMID: [https://pubmed.gov/14529683 14529683]</ref> | * Lymphadenectomy is generally not required as the tumor usually metastasize hematogenously and rarely through the lymph nodes.<ref name="pmid18506484">Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18506484 Prognostic factors and treatment outcomes of patients with uterine sarcoma: analysis of 127 patients at a single institution, 1989-2007.] ''J Cancer Res Clin Oncol'' 134 (12):1277-87. [http://dx.doi.org/10.1007/s00432-008-0422-2 DOI:10.1007/s00432-008-0422-2] PMID: [https://pubmed.gov/18506484 18506484]</ref><ref name="pmid14529683">Leitao MM, Sonoda Y, Brennan MF, Barakat RR, Chi DS (2003) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=14529683 Incidence of lymph node and ovarian metastases in leiomyosarcoma of the uterus.] ''Gynecol Oncol'' 91 (1):209-12. PMID: [https://pubmed.gov/14529683 14529683]</ref> | ||
Revision as of 19:11, 6 March 2019
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Leiomyosarcoma Microchapters |
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Treatment |
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Leiomyosarcoma surgery On the Web |
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American Roentgen Ray Society Images of Leiomyosarcoma surgery |
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Risk calculators and risk factors for Leiomyosarcoma surgery |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]
Overview
Patients with leiomyosarcoma have many treatment options but surgery is considered the mainstay of treatment for all soft tissue sarcomas. The selection depends on the stage of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods. Treatment options are not chosen by the histological subtype of sarcoma but by tumor grade, size, and location of primary or metastatic disease.
Surgery
- Surgery is mainstay of therapy in leiomyosarcoma patients, in case of recurrence or progression of disease combination therapy with chemoradiation can be used as well. [1]
- Hysterectomy with bilateral salpingooophorectomy has been the main effective way of surgical therapy in patients with leiomyosarcoma.
- Lymphadenectomy is generally not required as the tumor usually metastasize hematogenously and rarely through the lymph nodes.[2][3]
| Established Dx with CT/US and core biopsy reviewed by expert pathologist | |||||||||||||||||||||||||||||||||||||
| Established stage MRI of extremity and CXR/CT Chest | |||||||||||||||||||||||||||||||||||||
| Stage 1 low grade tumors | Stage 2 less than 5 cm high grade tumor | Stage 3 more than 5 cm high grade tumor or nodal disease | Stage 4 distant metastasis | ||||||||||||||||||||||||||||||||||
| Surgical resection | surgical resection with or without radiation | surgical resection with radiation with or without chemotherapy | chemotherapy with or without surgical resection | ||||||||||||||||||||||||||||||||||
References
- ↑ Vrzic-Petronijevic S, Likic-Ladjevic I, Petronijevic M, Argirovic R, Ladjevic N (2006). "Diagnosis and surgical therapy of uterine sarcoma". Acta Chir Iugosl. 53 (3): 67–72. PMID 17338203.
- ↑ Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT et al. (2008) Prognostic factors and treatment outcomes of patients with uterine sarcoma: analysis of 127 patients at a single institution, 1989-2007. J Cancer Res Clin Oncol 134 (12):1277-87. DOI:10.1007/s00432-008-0422-2 PMID: 18506484
- ↑ Leitao MM, Sonoda Y, Brennan MF, Barakat RR, Chi DS (2003) Incidence of lymph node and ovarian metastases in leiomyosarcoma of the uterus. Gynecol Oncol 91 (1):209-12. PMID: 14529683