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===Discovery===
===Discovery===
* There is limited information about the historical perspective of [disease name].
*The association between EBV and nasopharyngeal carcinoma was made in1970.<ref>{{Cite journal
OR
| author = [[H. zur Hausen]], [[H. Schulte-Holthausen]], [[G. Klein]], [[W. Henle]], [[G. Henle]], [[P. Clifford]] & [[L. Santesson]]
*[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
| title = EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx
 
| journal = [[Nature]]
*The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
| volume = 228
*In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
| issue = 5276
*In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
| pages = 1056–1058
 
| year = 1970
===Landmark Events in the Development of Treatment Strategies===
| month = December
 
| pmid = 4320657
===Impact on Cultural History===
}}</ref>
*In 1970, Zur Hausen and et al were the first to extract EBV DNA from NPC tumors by using  DNA hybridization method.<ref>{{Cite journal
| author = [[H. zur Hausen]], [[H. Schulte-Holthausen]], [[G. Klein]], [[W. Henle]], [[G. Henle]], [[P. Clifford]] & [[L. Santesson]]
| title = EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx
| journal = [[Nature]]
| volume = 228
| issue = 5276
| pages = 1056–1058
| year = 1970
| month = December
| pmid = 4320657
}}</ref>
*In 1970, Henle and et al revealed the link between stage of NPC tumors and EBV antibody titer.<ref>{{Cite journal
| author = [[W. Henle]], [[G. Henle]], [[H. C. Ho]], [[P. Burtin]], [[Y. Cachin]], [[P. Clifford]], [[A. de Schryver]], [[G. de-The]], [[V. Diehl]] & [[G. Klein]]
| title = Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups
| journal = [[Journal of the National Cancer Institute]]
| volume = 44
| issue = 1
| pages = 225–231
| year = 1970
| month = January
| pmid = 11515035
}}</ref>
*In 1973, Wolf and et al found EBV DNA in NPC tumor cells by in situ hybridization methods but not in infiltrating lymphoid cells.<ref>{{Cite journal
| author = [[H. Wolf]], [[H. zur Hausen]] & [[V. Becker]]
| title = EB viral genomes in epithelial nasopharyngeal carcinoma cells
| journal = [[Nature: New biology]]
| volume = 244
| issue = 138
| pages = 245–247
| year = 1973
| month = August
| pmid = 4353684
}}</ref>


===Famous Cases===
===Famous Cases===

Revision as of 19:08, 13 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]

Overview

Historical Perspective

Discovery

  • The association between EBV and nasopharyngeal carcinoma was made in1970.[1]
  • In 1970, Zur Hausen and et al were the first to extract EBV DNA from NPC tumors by using DNA hybridization method.[2]
  • In 1970, Henle and et al revealed the link between stage of NPC tumors and EBV antibody titer.[3]
  • In 1973, Wolf and et al found EBV DNA in NPC tumor cells by in situ hybridization methods but not in infiltrating lymphoid cells.[4]

Famous Cases

Babe Ruth, a famous baseball player suffered from nasopharyngeal cancer.[5]

References

  1. ↑ H. zur Hausen, H. Schulte-Holthausen, G. Klein, W. Henle, G. Henle, P. Clifford & L. Santesson (1970). "EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx". Nature. 228 (5276): 1056–1058. PMID 4320657. Unknown parameter |month= ignored (help)
  2. ↑ H. zur Hausen, H. Schulte-Holthausen, G. Klein, W. Henle, G. Henle, P. Clifford & L. Santesson (1970). "EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx". Nature. 228 (5276): 1056–1058. PMID 4320657. Unknown parameter |month= ignored (help)
  3. ↑ W. Henle, G. Henle, H. C. Ho, P. Burtin, Y. Cachin, P. Clifford, A. de Schryver, G. de-The, V. Diehl & G. Klein (1970). "Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups". Journal of the National Cancer Institute. 44 (1): 225–231. PMID 11515035. Unknown parameter |month= ignored (help)
  4. ↑ H. Wolf, H. zur Hausen & V. Becker (1973). "EB viral genomes in epithelial nasopharyngeal carcinoma cells". Nature: New biology. 244 (138): 245–247. PMID 4353684. Unknown parameter |month= ignored (help)
  5. ↑ "10 Famous People Who Have Suffered from Head and Neck Cancer – Dr. Jeffrey Faulkner, ENT".


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