Nasopharyngeal carcinoma pathophysiology: Difference between revisions
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==Pathology== | ==Pathology== | ||
===Gross Pathology=== | ===Gross Pathology=== | ||
*Nasal cavity involvement - common in early disease<ref name=pmid22194474 >{{Cite journal | last1 = Abdel Khalek Abdel Razek | first1 = A. | last2 = King | first2 = A. | title = MRI and CT of nasopharyngeal carcinoma. | journal = AJR Am J Roentgenol | volume = 198 | issue = 1 | pages = 11-8 | month = Jan | year = 2012 | doi = 10.2214/AJR.11.6954 | PMID = 22194474 }}</ref> | *Nasal cavity involvement - common in early disease<ref name="pmid22194474">{{Cite journal | last1 = Abdel Khalek Abdel Razek | first1 = A. | last2 = King | first2 = A. | title = MRI and CT of nasopharyngeal carcinoma. | journal = AJR Am J Roentgenol | volume = 198 | issue = 1 | pages = 11-8 | month = Jan | year = 2012 | doi = 10.2214/AJR.11.6954 | PMID = 22194474 }}</ref> | ||
The tumor arises from epithelial cells on the surface of the nasopharynx. | |||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
Features:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref> | Features:<ref name="Librepathology">Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref> | ||
*Prominent lymphoid component ([[Lymphoepithelioma]]) - '''key feature''' | *Prominent lymphoid component ([[Lymphoepithelioma]]) - '''key feature''' | ||
*Features of squamous cell carcinoma: | *Features of squamous cell carcinoma: | ||
| Line 37: | Line 40: | ||
Immunohistochemistry stains for nasopharyngeal carcinoma include: | Immunohistochemistry stains for nasopharyngeal carcinoma include: | ||
*EBER positive | *EBER positive | ||
*p16 negative<ref name=pmid9546345>{{cite journal |author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J |title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product |journal=Am. J. Pathol. |volume=152 |issue=4 |pages=865–9 |year=1998 |month=April |pmid=9546345 |pmc=1858242 |doi= |url=}}</ref> | *p16 negative<ref name="pmid9546345">{{cite journal |author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J |title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product |journal=Am. J. Pathol. |volume=152 |issue=4 |pages=865–9 |year=1998 |month=April |pmid=9546345 |pmc=1858242 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 15:57, 18 March 2019
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Nasopharyngeal carcinoma Microchapters |
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Differentiating Nasopharyngeal carcinoma from other Diseases |
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Nasopharyngeal carcinoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Nasopharyngeal carcinoma pathophysiology |
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Risk calculators and risk factors for Nasopharyngeal carcinoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]Faizan Sheraz, M.D. [3]
Overview
On microscopic histopathological analysis, abundant dense eosinophilic cytoplasm and prominent lymphoid component are characteristic findings of nasopharyngeal carcinoma.
Pathophysiology
Genetics
Genes involved in the pathogenesis of nasopharyngeal carcinoma include:
Pathology
Gross Pathology
- Nasal cavity involvement - common in early disease[1]
The tumor arises from epithelial cells on the surface of the nasopharynx.
Microscopic Pathology
Features:[2]
- Prominent lymphoid component (Lymphoepithelioma) - key feature
- Features of squamous cell carcinoma:
- Cohesive cells with:
- Abundant dense eosinophilic cytoplasm
- Central nuclei +/- small/indistinct nucleoli
- Cohesive cells with:
Nasopharyngeal carcinoma may be classified according to microscopic features into 3 subtypes:[3]
- Well-differentiated (keratinizing type)
- Moderately-differentiated (nonkeratinizing type)
- Undifferentiated (most strongly associated with Epstein-Barr virus infection)
-
Undifferentiated nasopharyngeal carcinoma - low power -
Undifferentiated nasopharyngeal carcinoma - med. power -
Undifferentiated nasopharyngeal carcinoma - high power
Immunohistochemistry
Immunohistochemistry stains for nasopharyngeal carcinoma include:
- EBER positive
- p16 negative[4]
References
- ↑ Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter
|month=ignored (help) - ↑ Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter
|month=ignored (help)