Testicular cancer laboratory findings: Difference between revisions
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* [[Human chorionic gonadotropin]] (HCG) | * [[Human chorionic gonadotropin]] (HCG) | ||
* [[Lactate dehydrogenase]] (LDH) | * [[Lactate dehydrogenase]] (LDH) | ||
'''Immunohistochemical markers:'''<ref name="pmid29262668">{{cite journal |vauthors=Boccellino M, Vanacore D, Zappavigna S, Cavaliere C, Rossetti S, D'Aniello C, Chieffi P, Amler E, Buonerba C, Di Lorenzo G, Di Franco R, Izzo A, Piscitelli R, Iovane G, Muto P, Botti G, Perdonà S, Caraglia M, Facchini G |title=Testicular cancer from diagnosis to epigenetic factors |journal=Oncotarget |volume=8 |issue=61 |pages=104654–104663 |date=November 2017 |pmid=29262668 |pmc=5732834 |doi=10.18632/oncotarget.20992 |url=}}</ref> | |||
*PLAP | |||
*OCT3/4(POU5F1) | |||
*NANOG | |||
*SOX2 | |||
*REX1 | |||
*AP-2gamma | |||
*LIN28 | |||
==References== | ==References== | ||
Revision as of 20:15, 21 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]
Overview
An elevated concentration of blood tumor marker tests is diagnostic of testicular cancer.
Laboratory Tests
| Tumor type | Tumor markers | ||
|---|---|---|---|
| HCG | AFP | LDH | |
| Seminomas | ↑ | - | ↑ |
| Choriocarcinoma | ↑↑ | - | ↑ |
| Yolk sack | - | ↑ | ↑ |
| Embryonal | ↑ | ↑ | ↑ |
| Teratoma | - | ↑ | ↑ |
- Alpha-fetoprotein (AFP)
- Human chorionic gonadotropin (HCG)
- Lactate dehydrogenase (LDH)
Immunohistochemical markers:[3]
- PLAP
- OCT3/4(POU5F1)
- NANOG
- SOX2
- REX1
- AP-2gamma
- LIN28
References
- ↑ Milose JC, Filson CP, Weizer AZ, Hafez KS, Montgomery JS (December 2011). "Role of biochemical markers in testicular cancer: diagnosis, staging, and surveillance". Open Access J Urol. 4: 1–8. doi:10.2147/OAJU.S15063. PMC 3818947. PMID 24198649.
- ↑ Gilligan TD, Seidenfeld J, Basch EM, Einhorn LH, Fancher T, Smith DC, Stephenson AJ, Vaughn DJ, Cosby R, Hayes DF (July 2010). "American Society of Clinical Oncology Clinical Practice Guideline on uses of serum tumor markers in adult males with germ cell tumors". J. Clin. Oncol. 28 (20): 3388–404. doi:10.1200/JCO.2009.26.4481. PMID 20530278.
- ↑ Boccellino M, Vanacore D, Zappavigna S, Cavaliere C, Rossetti S, D'Aniello C, Chieffi P, Amler E, Buonerba C, Di Lorenzo G, Di Franco R, Izzo A, Piscitelli R, Iovane G, Muto P, Botti G, Perdonà S, Caraglia M, Facchini G (November 2017). "Testicular cancer from diagnosis to epigenetic factors". Oncotarget. 8 (61): 104654–104663. doi:10.18632/oncotarget.20992. PMC 5732834. PMID 29262668.