Leiomyosarcoma laboratory tests: Difference between revisions
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{{Leiomyosarcoma}} | |||
{{CMG}};{{AE}} | |||
== Overview: == | == Overview: == | ||
There are no specific laboratory findings associated with leiomyosarcoma, patients may have low [[hemoglobin]] and [[Red blood cell|red blood cells]] on their complete blood count, immunohistochemistry markers can be positive but non-diagnostics. | There are no specific laboratory findings associated with leiomyosarcoma, patients may have low [[hemoglobin]] and [[Red blood cell|red blood cells]] on their complete blood count, immunohistochemistry markers can be positive but non-diagnostics. | ||
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* Negative with [[S100A1|S100]], [[c-kit]] and [[CD34]] | * Negative with [[S100A1|S100]], [[c-kit]] and [[CD34]] | ||
==References== | ==References== | ||
Revision as of 16:50, 2 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief:
Overview:
There are no specific laboratory findings associated with leiomyosarcoma, patients may have low hemoglobin and red blood cells on their complete blood count, immunohistochemistry markers can be positive but non-diagnostics.
Lab test:
There are no specific laboratory findings associated with leiomyosarcoma. Elevated levels of CA-125 and LDH( isozymes) in women with uterine sarcoma, usefulness of these markers are still being investigated.There are imunohistochemistry markers associated with sarcoma but it can be positive in any other soft tissue tumors, some of these markers are include:[1][2][3]
- Actin and desmin positive.
- Diffusely positive with calponin, h-caldesmon.
- Negative with S100, c-kit and CD34
References
- ↑ R, Stramare; G, Orsatti (2016). "Imaging Features, Differential Diagnosis and Management of Leiomyosarcomas: Case Series and Review of the Literature". Journal of Cancer Science & Therapy. 08 (04). doi:10.4172/1948-5956.1000397. ISSN 1948-5956.
- ↑ Goto A, Takeuchi S, Sugimura K, Maruo T (2002) Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus. Int J Gynecol Cancer 12 (4):354-61. PMID: 12144683
- ↑ Hoskins PJ, Le N (2008) Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus. Int J Gynecol Cancer 18 (6):1200-1. DOI:10.1111/j.1525-1438.2007.01187.x PMID: 18217961