Schwannoma: Difference between revisions
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{{CMG}}; {{AE}} {{SC}} | {{CMG}}; {{AE}} {{SC}} | ||
{{SK}} Neurilemmoma, Neurinoma, Neurolemmoma, Schwann cell tumor | {{SK}} Neurilemmoma, Neurinoma, Neurolemmoma, Schwann cell tumor, Schwannomatosis | ||
==[[Schwannoma overview|Overview]]== | ==[[Schwannoma overview|Overview]]== | ||
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==[[Schwannoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]== | ==[[Schwannoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]== | ||
{{SI}} | |||
==Overview== | |||
'''Schwannomatosis''' is one form of a genetic disorder called [[Neurofibromatosis]] (NF) that has only recently been recognized. It is a rare disorder, affecting only around 1:40,000 individuals. | |||
== Symptoms == | |||
* [[Schwannomas_and_Neurofibromas|Schwannomas]] occur instead of [[Neurofibroma|Neurofibromas]]. | |||
* Multiple Schwannomas occur. | |||
* The Schwannomas develop on cranial, spinal and peripheral nerves. | |||
* Chronic pain, and sometimes numbness, tingling and weakness. | |||
* About 1/3 of patients have segmental Schwannomatosis, which means that the Schwannomas are limited to a single part of the body, such as an arm, a leg or the spine. | |||
* There are several cases where people with Schwannomatosis have developed a vestibular Schwannoma ([[acoustic neuroma]]). | |||
* Patients with Schwannomatosis do not have learning disabilities related to the disease. | |||
* Symptoms are generally brought on by hormonal changes such as puberty and pregnancy. | |||
== Cause == | |||
* Like the NF1 and NF2 genes, the candidate Schwannomatosis gene, named INI1, is a tumor suppressor that regulates cell cycle, growth and differentiation. INI1 is also known as SMARCB1, hSNF5, or BAF47, and lies on human Chromosome 22. INI1 is also mutated in other tumors including malignant brain & kidney tumors in infants. | |||
* Schwannomatosis is known to be a genetic disorder, however it can skip generations. | |||
== Treatment == | |||
* If feasible, the Schwannomas can be surgically removed. Any tumor-associated pain usually subsides after tumor removal. Damaged nerves and scar tissue can be a result of surgery and pain can be an ongoing problem. | |||
* Sometimes, a tumor will reappear at the same site after surgery. | |||
* If surgery is unfeasible, then pain management will have to be used. Schwannomatosis can sometimes cause severe, untreatable pain over time. | |||
* Other than surgery and/or pain management, there are no other medical treatments available. There are no drugs available to treat Schwannomatosis. | |||
* Gamma knife surgery can be performed on head tumors to help slow growth of a tumor, although there is no guarantee that it will work. | |||
* Recently, many advances are being made in the treatment of schwannomas. Of interest is '''CyberKnife''', manufactured by '''Accuray'''. Success rates, although limited in data, appear to be in the low to mid ninety percent range. | |||
[[Category:Neurological disorders]] | |||
[[Category:Types of cancer]] | |||
{{WikiDoc Help Menu}} | |||
{{WikiDoc Sources}} | |||
==Diagnosis== | ==Diagnosis== | ||
Revision as of 19:11, 14 May 2019
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Schwannoma Microchapters |
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American Roentgen Ray Society Images of Schwannoma |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Synonyms and keywords: Neurilemmoma, Neurinoma, Neurolemmoma, Schwann cell tumor, Schwannomatosis
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Schwannoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
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WikiDoc Resources for Schwannoma |
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Articles |
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Most recent articles on Schwannoma |
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US National Guidelines Clearinghouse on Schwannoma
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Books |
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News |
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Commentary |
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Definitions |
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Patient Resources / Community |
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Patient resources on Schwannoma Discussion groups on Schwannoma Patient Handouts on Schwannoma Directions to Hospitals Treating Schwannoma Risk calculators and risk factors for Schwannoma
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Causes & Risk Factors for Schwannoma |
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International |
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Overview
Schwannomatosis is one form of a genetic disorder called Neurofibromatosis (NF) that has only recently been recognized. It is a rare disorder, affecting only around 1:40,000 individuals.
Symptoms
- Schwannomas occur instead of Neurofibromas.
- Multiple Schwannomas occur.
- The Schwannomas develop on cranial, spinal and peripheral nerves.
- Chronic pain, and sometimes numbness, tingling and weakness.
- About 1/3 of patients have segmental Schwannomatosis, which means that the Schwannomas are limited to a single part of the body, such as an arm, a leg or the spine.
- There are several cases where people with Schwannomatosis have developed a vestibular Schwannoma (acoustic neuroma).
- Patients with Schwannomatosis do not have learning disabilities related to the disease.
- Symptoms are generally brought on by hormonal changes such as puberty and pregnancy.
Cause
- Like the NF1 and NF2 genes, the candidate Schwannomatosis gene, named INI1, is a tumor suppressor that regulates cell cycle, growth and differentiation. INI1 is also known as SMARCB1, hSNF5, or BAF47, and lies on human Chromosome 22. INI1 is also mutated in other tumors including malignant brain & kidney tumors in infants.
- Schwannomatosis is known to be a genetic disorder, however it can skip generations.
Treatment
- If feasible, the Schwannomas can be surgically removed. Any tumor-associated pain usually subsides after tumor removal. Damaged nerves and scar tissue can be a result of surgery and pain can be an ongoing problem.
- Sometimes, a tumor will reappear at the same site after surgery.
- If surgery is unfeasible, then pain management will have to be used. Schwannomatosis can sometimes cause severe, untreatable pain over time.
- Other than surgery and/or pain management, there are no other medical treatments available. There are no drugs available to treat Schwannomatosis.
- Gamma knife surgery can be performed on head tumors to help slow growth of a tumor, although there is no guarantee that it will work.
- Recently, many advances are being made in the treatment of schwannomas. Of interest is CyberKnife, manufactured by Accuray. Success rates, although limited in data, appear to be in the low to mid ninety percent range.
Diagnosis
Staging | History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies | Biopsy
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
Related Chapters
- Neurofibroma
- Vestibular schwannoma (Acoustic neuroma)