Radiation proctitis future or investigational therapies: Difference between revisions
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Recent studies on chronic radiation proctitis suggested 2.12- to 7.31-fold higher expression levels of angiogenin, fibroblast growth factor 1 (FGF1), endoglin, matrix metalloproteinase (MMP)-8, urokinase-type plasminogen activator (uPA) and maspin in radiation proctitis tissues compared with normal rectal mucosa.Based on the this study, it has been concluded that Inhibitors of angiogenic factors such as angiogenin and FGF1 may be effective for treating radiation proctitis in future.<ref name="TakeuchiKimura2011">{{cite journal|last1=Takeuchi|first1=Hisashi|last2=Kimura|first2=Tetsuo|last3=Okamoto|first3=Koichi|last4=Aoyagi|first4=Eriko|last5=Miyamoto|first5=Hiroshi|last6=Kaji|first6=Masako|last7=Takenaka|first7=Hidetaka|last8=Okamura|first8=Seisuke|last9=Sato|first9=Yasushi|last10=Kato|first10=Junji|last11=Okahisa|first11=Toshiya|last12=Takayama|first12=Tetsuji|title=A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors|journal=Journal of Gastroenterology|volume=47|issue=1|year=2011|pages=56–64|issn=0944-1174|doi=10.1007/s00535-011-0470-2}}</ref> | Recent studies on chronic radiation proctitis suggested 2.12- to 7.31-fold higher expression levels of angiogenin, fibroblast growth factor 1 (FGF1), endoglin, [[matrix metalloproteinase]] (MMP)-8, urokinase-type [[plasminogen activator]] (uPA) and [[maspin]] in radiation proctitis tissues compared with normal rectal mucosa.Based on the this study, it has been concluded that Inhibitors of angiogenic factors such as angiogenin and FGF1 may be effective for treating radiation proctitis in future.<ref name="TakeuchiKimura2011">{{cite journal|last1=Takeuchi|first1=Hisashi|last2=Kimura|first2=Tetsuo|last3=Okamoto|first3=Koichi|last4=Aoyagi|first4=Eriko|last5=Miyamoto|first5=Hiroshi|last6=Kaji|first6=Masako|last7=Takenaka|first7=Hidetaka|last8=Okamura|first8=Seisuke|last9=Sato|first9=Yasushi|last10=Kato|first10=Junji|last11=Okahisa|first11=Toshiya|last12=Takayama|first12=Tetsuji|title=A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors|journal=Journal of Gastroenterology|volume=47|issue=1|year=2011|pages=56–64|issn=0944-1174|doi=10.1007/s00535-011-0470-2}}</ref> | ||
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Revision as of 07:19, 18 June 2019
Recent studies on chronic radiation proctitis suggested 2.12- to 7.31-fold higher expression levels of angiogenin, fibroblast growth factor 1 (FGF1), endoglin, matrix metalloproteinase (MMP)-8, urokinase-type plasminogen activator (uPA) and maspin in radiation proctitis tissues compared with normal rectal mucosa.Based on the this study, it has been concluded that Inhibitors of angiogenic factors such as angiogenin and FGF1 may be effective for treating radiation proctitis in future.[1]
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References
- ↑ Takeuchi, Hisashi; Kimura, Tetsuo; Okamoto, Koichi; Aoyagi, Eriko; Miyamoto, Hiroshi; Kaji, Masako; Takenaka, Hidetaka; Okamura, Seisuke; Sato, Yasushi; Kato, Junji; Okahisa, Toshiya; Takayama, Tetsuji (2011). "A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors". Journal of Gastroenterology. 47 (1): 56–64. doi:10.1007/s00535-011-0470-2. ISSN 0944-1174.