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[[Chondromyxoid fibroma]] (CMF) is a rare, slow-growing, [[benign]] [[bone tumor]] of chondroblastic derivation. Approximately 70% of patients with chondromyxoid fibroma have [[symptoms]] at the time of [[diagnosis]]; the remaining [[lesions]] are found incidentally. Chondromyxoid fibroma (CMF) represents less than 1% of all [[benign]] [[bone neoplasms]]. It is a slow-growing, locally destructive [[tumor]].<ref name="KhalatbariHamidi2012">{{cite journal|last1=Khalatbari|first1=Mahmoud|last2=Hamidi|first2=Mehrdokht|last3=Moharamzad|first3=Yashar|title=Chondromyxoid Fibroma of the Anterior Skull Base Invading the Orbit in a Pediatric Patient: Case Report and Review of the Literature|journal=Neuropediatrics|volume=43|issue=03|year=2012|pages=140–145|issn=0174-304X|doi=10.1055/s-0032-1307460}}</ref> [[Pain]] is the most common [[symptom]] and may be present for years. While typically mild, the [[pain]] may become severe with time, and night [[symptoms]] may be present. [[Patients]] may also report [[stiffness]] and [[swelling]]. As a consequence of slow growth of the [[tumor]], [[Pathological|pathologic]] [[fractures]] have been rarely reported. Chondromyxoid fibroma is an unusual [[benign]] [[tumor]] of [[cartilaginous]] [[tissues]].<ref name="E.E.2005">{{cite journal|last1=E.|first1=Estrada-Villaseñor|last2=E.|first2=Delgado Cedillo|last3=G.|first3=Rico Martínez|last4=R.|first4=Delgado Chávez|title=Periosteal chondromyxoid fibroma: A case study using imprint cytology|journal=Diagnostic Cytopathology|volume=33|issue=6|year=2005|pages=402–406|issn=8755-1039|doi=10.1002/dc.20357}}</ref><ref name="pmid7761324">{{cite journal| author=McGrory BJ, Inwards CY, McLeod RA, Sim FH| title=Chondromyxoid fibroma. | journal=Orthopedics | year= 1995 | volume= 18 | issue= 3 | pages= 307-10 | pmid=7761324 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7761324  }} </ref><ref name="pmid8717127">{{cite journal| author=White PG, Saunders L, Orr W, Friedman L| title=Chondromyxoid fibroma. | journal=Skeletal Radiol | year= 1996 | volume= 25 | issue= 1 | pages= 79-81 | pmid=8717127 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8717127  }} </ref><ref name="pmid5110934">{{cite journal| author=Schutt PG, Frost HM| title=Chondromyxoid fibroma. | journal=Clin Orthop Relat Res | year= 1971 | volume= 78 | issue=  | pages= 323-9 | pmid=5110934 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5110934  }} </ref><ref name="pmid14038586">{{cite journal| author=RALPH LL| title=Chondromyxoid fibroma of bone. | journal=J Bone Joint Surg Br | year= 1962 | volume= 44-B | issue=  | pages= 7-24 | pmid=14038586 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14038586  }} </ref>
[[Chondromyxoid fibroma]] (CMF) is a rare, slow-growing, [[benign]] [[bone tumor]] of chondroblastic derivation. Approximately 70% of patients with chondromyxoid fibroma have [[symptoms]] at the time of [[diagnosis]]; the remaining [[lesions]] are found incidentally. Chondromyxoid fibroma (CMF) represents less than 1% of all [[benign]] [[bone neoplasms]]. It is a slow-growing, locally destructive [[tumor]].<ref name="KhalatbariHamidi2012">{{cite journal|last1=Khalatbari|first1=Mahmoud|last2=Hamidi|first2=Mehrdokht|last3=Moharamzad|first3=Yashar|title=Chondromyxoid Fibroma of the Anterior Skull Base Invading the Orbit in a Pediatric Patient: Case Report and Review of the Literature|journal=Neuropediatrics|volume=43|issue=03|year=2012|pages=140–145|issn=0174-304X|doi=10.1055/s-0032-1307460}}</ref> [[Pain]] is the most common [[symptom]] and may be present for years. While typically mild, the [[pain]] may become severe with time, and night [[symptoms]] may be present. [[Patients]] may also report [[stiffness]] and [[swelling]]. As a consequence of slow growth of the [[tumor]], [[Pathological|pathologic]] [[fractures]] have been rarely reported. Chondromyxoid fibroma is an unusual [[benign]] [[tumor]] of [[cartilaginous]] [[tissues]].<ref name="E.E.2005">{{cite journal|last1=E.|first1=Estrada-Villaseñor|last2=E.|first2=Delgado Cedillo|last3=G.|first3=Rico Martínez|last4=R.|first4=Delgado Chávez|title=Periosteal chondromyxoid fibroma: A case study using imprint cytology|journal=Diagnostic Cytopathology|volume=33|issue=6|year=2005|pages=402–406|issn=8755-1039|doi=10.1002/dc.20357}}</ref><ref name="pmid7761324">{{cite journal| author=McGrory BJ, Inwards CY, McLeod RA, Sim FH| title=Chondromyxoid fibroma. | journal=Orthopedics | year= 1995 | volume= 18 | issue= 3 | pages= 307-10 | pmid=7761324 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7761324  }} </ref><ref name="pmid8717127">{{cite journal| author=White PG, Saunders L, Orr W, Friedman L| title=Chondromyxoid fibroma. | journal=Skeletal Radiol | year= 1996 | volume= 25 | issue= 1 | pages= 79-81 | pmid=8717127 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8717127  }} </ref><ref name="pmid5110934">{{cite journal| author=Schutt PG, Frost HM| title=Chondromyxoid fibroma. | journal=Clin Orthop Relat Res | year= 1971 | volume= 78 | issue=  | pages= 323-9 | pmid=5110934 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5110934  }} </ref><ref name="pmid14038586">{{cite journal| author=RALPH LL| title=Chondromyxoid fibroma of bone. | journal=J Bone Joint Surg Br | year= 1962 | volume= 44-B | issue=  | pages= 7-24 | pmid=14038586 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14038586  }} </ref>
===Oral Fibroma===
===Oral Fibroma===
A history of [[chronic]] [[irritation]] to the area or [[trauma]] followed by the [[development]] of a [[sessile]], firm [[mass]] is characteristic of oral fibroma. The majority of fibromas represent reactive focal [[fibrous]] [[hyperplasia]] due to local [[irritation]] or [[trauma]]. The fibroma may occur in any area, although the areas most frequently affected include the areas most easily [[Trauma|traumatized]], such as the [[tongue]], [[buccal mucosa]], and [[labia]]<nowiki/>l [[mucosa]]. They are [[benign]] [[lesions]] and they do not have [[malignant]] potential and recurrence is mostly as a result of failure to eliminate the [[irritation]]. [[Oral fibroma]] generally presents as a painless, [[sessile]], [[ovoid]] or round, broad based growth. Oral fibromas develop over weeks or months to reach a maximum size which is approximately 1 cm in diameter, but can sometimes be larger.<ref>Regezi, Joseph A., James J. Sciubba, and Richard C. Jordan. Oral Pathology Clinical Pathologic Correlations. City: Elsevier Health Sciences, 2015. Print.</ref><ref>Rangeeth, B. N., Joyson Moses, and Veera Kishore Kumar Reddy. "A rare presentation of mucocele and irritation fibroma of the lower lip." Contemporary clinical dentistry 1.2 (2010): 111.</ref><ref>Vilmann, A., P. Vilmann, and H. Vilmann. "Pyogenic granuloma: evaluation of oral conditions." British journal of oral and Maxillofacial surgery 24.5 (1986): 376-382.</ref><ref>Kolte, Abhay P., Rajshri A. Kolte, and Tushar S. Shrirao. "Focal fibrous overgrowths: A case series and review of literature." Contemporary clinical dentistry 1.4 (2010): 271.</ref>
 
* A history of [[chronic]] [[irritation]] to the area or [[trauma]] followed by the [[development]] of a [[sessile]], firm [[mass]] is characteristic of oral fibroma. The majority of fibromas represent reactive focal [[fibrous]] [[hyperplasia]] due to local [[irritation]] or [[trauma]]. The fibroma may occur in any area, although the areas most frequently affected include the areas most easily [[Trauma|traumatized]], such as the [[tongue]], [[buccal mucosa]], and [[labia]]<nowiki/>l [[mucosa]]. They are [[benign]] [[lesions]] and they do not have [[malignant]] potential and recurrence is mostly as a result of failure to eliminate the [[irritation]]. [[Oral fibroma]] generally presents as a painless, [[sessile]], [[ovoid]] or round, broad based growth. Oral fibromas develop over weeks or months to reach a maximum size which is approximately 1 cm in diameter, but can sometimes be larger.<ref>Regezi, Joseph A., James J. Sciubba, and Richard C. Jordan. Oral Pathology Clinical Pathologic Correlations. City: Elsevier Health Sciences, 2015. Print.</ref><ref>Rangeeth, B. N., Joyson Moses, and Veera Kishore Kumar Reddy. "A rare presentation of mucocele and irritation fibroma of the lower lip." Contemporary clinical dentistry 1.2 (2010): 111.</ref><ref>Vilmann, A., P. Vilmann, and H. Vilmann. "Pyogenic granuloma: evaluation of oral conditions." British journal of oral and Maxillofacial surgery 24.5 (1986): 376-382.</ref><ref>Kolte, Abhay P., Rajshri A. Kolte, and Tushar S. Shrirao. "Focal fibrous overgrowths: A case series and review of literature." Contemporary clinical dentistry 1.4 (2010): 271.</ref>


===Desmoplastic Fibroma===
===Desmoplastic Fibroma===
[[Desmoplastic fibroma]] (DF) is an extremely rare [[benign]] [[intraosseous]] [[tumor]] with locally aggressive and infiltrative characteristics. The [[clinical]] presentation of desmoplastic fibroma is nonspecific and usually presents as [[pain]] over the affected area and occasionally as a [[palpable]] [[mass]], although [[Pathological|pathologic]] [[fracture]] has been described previously as a common reason for seeking treatment. Desmoplastic fibroma has also been presented as an incidental finding. The most common sites of involvement are the [[mandible]] and the [[metaphysis]] of long bones. Biologically and histologically, desmoplastic fibroma mimics extra-abdominal desmoid tumor of soft tissue. Morphologically a distinction between desmoplastic fibroma and aggressive fibromatosis ([[desmoid tumor]]) is not possible.<ref name="pmid23459513">{{cite journal| author=Nedopil A, Raab P, Rudert M| title=Desmoplastic fibroma: a case report with three years of clinical and radiographic observation and review of the literature. | journal=Open Orthop J | year= 2013 | volume= 8 | issue=  | pages= 40-6 | pmid=23459513 | doi=10.2174/1874325001307010040 | pmc=PMC3583030 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23459513  }} </ref><ref name="pmid19930688">{{cite journal |vauthors=Schneider M, Zimmermann AC, Depprich RA, Kübler NR, Engers R, Naujoks CD, Handschel J |title=Desmoplastic fibroma of the mandible--review of the literature and presentation of a rare case |journal=Head Face Med |volume=5 |issue= |pages=25 |date=November 2009 |pmid=19930688 |pmc=2787487 |doi=10.1186/1746-160X-5-25 |url=}}</ref><ref name="pmid19032395">{{cite journal |vauthors=Apaydin M, Gelal F, Avci A, Adinas C, Sarsilmaz A, Varer M |title=Desmoplastic fibroma in humerus |journal=J Med Imaging Radiat Oncol |volume=52 |issue=5 |pages=489–90 |date=October 2008 |pmid=19032395 |doi=10.1111/j.1440-1673.2008.01989.x |url=}}</ref>
 
* [[Desmoplastic fibroma]] (DF) is an extremely rare [[benign]] [[intraosseous]] [[tumor]] with locally aggressive and infiltrative characteristics. The [[clinical]] presentation of desmoplastic fibroma is nonspecific and usually presents as [[pain]] over the affected area and occasionally as a [[palpable]] [[mass]], although [[Pathological|pathologic]] [[fracture]] has been described previously as a common reason for seeking treatment. Desmoplastic fibroma has also been presented as an incidental finding. The most common sites of involvement are the [[mandible]] and the [[metaphysis]] of long bones. Biologically and histologically, desmoplastic fibroma mimics extra-abdominal desmoid tumor of soft tissue. Morphologically a distinction between desmoplastic fibroma and aggressive fibromatosis ([[desmoid tumor]]) is not possible.<ref name="pmid23459513">{{cite journal| author=Nedopil A, Raab P, Rudert M| title=Desmoplastic fibroma: a case report with three years of clinical and radiographic observation and review of the literature. | journal=Open Orthop J | year= 2013 | volume= 8 | issue=  | pages= 40-6 | pmid=23459513 | doi=10.2174/1874325001307010040 | pmc=PMC3583030 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23459513  }} </ref><ref name="pmid19930688">{{cite journal |vauthors=Schneider M, Zimmermann AC, Depprich RA, Kübler NR, Engers R, Naujoks CD, Handschel J |title=Desmoplastic fibroma of the mandible--review of the literature and presentation of a rare case |journal=Head Face Med |volume=5 |issue= |pages=25 |date=November 2009 |pmid=19930688 |pmc=2787487 |doi=10.1186/1746-160X-5-25 |url=}}</ref><ref name="pmid19032395">{{cite journal |vauthors=Apaydin M, Gelal F, Avci A, Adinas C, Sarsilmaz A, Varer M |title=Desmoplastic fibroma in humerus |journal=J Med Imaging Radiat Oncol |volume=52 |issue=5 |pages=489–90 |date=October 2008 |pmid=19032395 |doi=10.1111/j.1440-1673.2008.01989.x |url=}}</ref>


===Non-ossifying Fibroma===
===Non-ossifying Fibroma===
[[Nonossifying fibroma]] (NOF) is a common type of [[benign]] [[fibrous]] [[lesion]] that occurs in the [[metaphysis]] of the [[long bones]] of the [[lower extremities]]. While the NOF occurs with relative frequency in the [[long bones]], NOF of the [[mandible]] and other areas of the [[skeleton]] are rare. The majority of NOFs are [[asymptomatic]]; however, those that are particularly large may cause [[chronic pain]] and/or [[Pathological|pathologic]] [[fracture]] in the [[long bones]]. [[Diagnosis]] of NOF in the [[long bones]] is usually based upon the characteristic [[clinical]] and [[radiographic]] appearance. Typically the NOF appears as an [[asymptomatic]] multiloculated [[lesion]] often identified incidentally during [[radiographic]] evaluation indicated for another reason. [[Mandibular]] [[lesions]] of the NOF may be [[asymptomatic]] or may present with expansion. Non-ossifying fibromas are typically self-limiting and spontaneous resolution at [[skeletal]] maturity is usually seen. This spontaneous regression, usually starting at the end of [[adolescence]], has been observed to occur over periods of 29–52 months. Recurrence is rare. The [[clinical]] behavior of [[mandibular]] NOF appears to be that of a [[benign]] [[lesion]] with no reports of recurrence, as seen in the [[long bones]].<ref name="pmid23008139">{{cite journal| author=Bowers LM, Cohen DM, Bhattacharyya I, Pettigrew JC, Stavropoulos MF| title=The non-ossifying fibroma: a case report and review of the literature. | journal=Head Neck Pathol | year= 2013 | volume= 7 | issue= 2 | pages= 203-10 | pmid=23008139 | doi=10.1007/s12105-012-0399-7 | pmc=PMC3642261 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23008139  }} </ref><ref name="SakamotoIshii2012">{{cite journal|last1=Sakamoto|first1=Akio|last2=Ishii|first2=Takeaki|last3=Oda|first3=Yoshinao|last4=Iwamoto|first4=Yukihide|title=Nonossifying fibroma presenting as an aneurysmal bone cyst: a case report|journal=Journal of Medical Case Reports|volume=6|issue=1|year=2012|pages=407|issn=1752-1947|doi=10.1186/1752-1947-6-407}}</ref><ref name="BowersCohen2012">{{cite journal|last1=Bowers|first1=Leah M.|last2=Cohen|first2=Donald M.|last3=Bhattacharyya|first3=Indraneel|last4=Pettigrew|first4=James C.|last5=Stavropoulos|first5=Mary F.|title=The Non-ossifying Fibroma: A Case Report and Review of the Literature|journal=Head and Neck Pathology|volume=7|issue=2|year=2012|pages=203–210|issn=1936-055X|doi=10.1007/s12105-012-0399-7}}</ref><ref name="pmid27044378">{{cite journal |vauthors=Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O |title=Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up |journal=BMC Musculoskelet Disord |volume=17 |issue= |pages=147 |date=April 2016 |pmid=27044378 |pmc=4820930 |doi=10.1186/s12891-016-1004-0 |url=}}</ref>
 
* [[Nonossifying fibroma]] (NOF) is a common type of [[benign]] [[fibrous]] [[lesion]] that occurs in the [[metaphysis]] of the [[long bones]] of the [[lower extremities]]. While the NOF occurs with relative frequency in the [[long bones]], NOF of the [[mandible]] and other areas of the [[skeleton]] are rare. The majority of NOFs are [[asymptomatic]]; however, those that are particularly large may cause [[chronic pain]] and/or [[Pathological|pathologic]] [[fracture]] in the [[long bones]]. [[Diagnosis]] of NOF in the [[long bones]] is usually based upon the characteristic [[clinical]] and [[radiographic]] appearance. Typically the NOF appears as an [[asymptomatic]] multiloculated [[lesion]] often identified incidentally during [[radiographic]] evaluation indicated for another reason. [[Mandibular]] [[lesions]] of the NOF may be [[asymptomatic]] or may present with expansion. Non-ossifying fibromas are typically self-limiting and spontaneous resolution at [[skeletal]] maturity is usually seen. This spontaneous regression, usually starting at the end of [[adolescence]], has been observed to occur over periods of 29–52 months. Recurrence is rare. The [[clinical]] behavior of [[mandibular]] NOF appears to be that of a [[benign]] [[lesion]] with no reports of recurrence, as seen in the [[long bones]].<ref name="pmid23008139">{{cite journal| author=Bowers LM, Cohen DM, Bhattacharyya I, Pettigrew JC, Stavropoulos MF| title=The non-ossifying fibroma: a case report and review of the literature. | journal=Head Neck Pathol | year= 2013 | volume= 7 | issue= 2 | pages= 203-10 | pmid=23008139 | doi=10.1007/s12105-012-0399-7 | pmc=PMC3642261 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23008139  }} </ref><ref name="SakamotoIshii2012">{{cite journal|last1=Sakamoto|first1=Akio|last2=Ishii|first2=Takeaki|last3=Oda|first3=Yoshinao|last4=Iwamoto|first4=Yukihide|title=Nonossifying fibroma presenting as an aneurysmal bone cyst: a case report|journal=Journal of Medical Case Reports|volume=6|issue=1|year=2012|pages=407|issn=1752-1947|doi=10.1186/1752-1947-6-407}}</ref><ref name="BowersCohen2012">{{cite journal|last1=Bowers|first1=Leah M.|last2=Cohen|first2=Donald M.|last3=Bhattacharyya|first3=Indraneel|last4=Pettigrew|first4=James C.|last5=Stavropoulos|first5=Mary F.|title=The Non-ossifying Fibroma: A Case Report and Review of the Literature|journal=Head and Neck Pathology|volume=7|issue=2|year=2012|pages=203–210|issn=1936-055X|doi=10.1007/s12105-012-0399-7}}</ref><ref name="pmid27044378">{{cite journal |vauthors=Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O |title=Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up |journal=BMC Musculoskelet Disord |volume=17 |issue= |pages=147 |date=April 2016 |pmid=27044378 |pmc=4820930 |doi=10.1186/s12891-016-1004-0 |url=}}</ref>


==Complications==
==Complications==

Revision as of 13:40, 1 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2], Simrat Sarai, M.D. [3]

Overview

Common complications of chondromyxoid, ossifying and non-ossifying fibroma include pathological fractures. Depending on the type of the fibroma, the prognosis may vary. However, the prognosis is generally regarded as excellent for nonossifying fibroma. Ossifying fibromas tend to regress over time. Ossifying fibroma is noninvasive tumor. It will recur if it is excised before skeletal maturity. Excision after skeletal maturity is usually successful. Oral fibromas are benign tumors. Recurrence of oral fibromas is possible, however, if the offending irritant persists. Desmoplastic fibromas are benign and locally aggressive tumors. Desmoplastic fibroma is a rare benign intraosseous tumor neoplasm. Desmoplastic fibroma has a recurrence rate of approximately 37% to 72%. The average rate of recurrence after curettage has been reported to be approximately 55%.[1][2][3]

Natural History

Cemento-ossifying fibroma

  • Clinically, cemento-ossifying fibroma manifest as a slow-growing intrabony mass that is normally well delimited and asymptomatic, although over time the lesion may become large enough to cause facial deformation. Cemento-ossifying fibroma is a benign fibro-osseous maxillary tumor. It is a slow-growing lesion. Approximately one-half of all cases are asymptomatic, the growth of the tumor over time may lead to facial asymmetry, with the appearance of a mass causing facial discomfort or mandibular expansion, and the possible displacement of dental roots. Juvenile aggressive cemento-ossifying fibroma presents in children and is clinically more aggressive and pathologically more vascular.[4]


Chondromyxoid Fibroma

Chondromyxoid fibroma (CMF) is a rare, slow-growing, benign bone tumor of chondroblastic derivation. Approximately 70% of patients with chondromyxoid fibroma have symptoms at the time of diagnosis; the remaining lesions are found incidentally. Chondromyxoid fibroma (CMF) represents less than 1% of all benign bone neoplasms. It is a slow-growing, locally destructive tumor.[10] Pain is the most common symptom and may be present for years. While typically mild, the pain may become severe with time, and night symptoms may be present. Patients may also report stiffness and swelling. As a consequence of slow growth of the tumor, pathologic fractures have been rarely reported. Chondromyxoid fibroma is an unusual benign tumor of cartilaginous tissues.[11][12][13][14][15]

Oral Fibroma

Desmoplastic Fibroma

  • Desmoplastic fibroma (DF) is an extremely rare benign intraosseous tumor with locally aggressive and infiltrative characteristics. The clinical presentation of desmoplastic fibroma is nonspecific and usually presents as pain over the affected area and occasionally as a palpable mass, although pathologic fracture has been described previously as a common reason for seeking treatment. Desmoplastic fibroma has also been presented as an incidental finding. The most common sites of involvement are the mandible and the metaphysis of long bones. Biologically and histologically, desmoplastic fibroma mimics extra-abdominal desmoid tumor of soft tissue. Morphologically a distinction between desmoplastic fibroma and aggressive fibromatosis (desmoid tumor) is not possible.[1][20][21]

Non-ossifying Fibroma

Complications

Ovarian Fibroma

Ossifying- Fibroma

Non-ossifying Fibroma

Chondromyxoid fibromas

Uterine Fibromas

Prognosis

Non-ossifying Fibroma

Generally, the prognosis for nonossifying fibroma is excellent. They usually fill in during adolescence. The risk of recurrence is usually lower than for other benign tumors.[2]

Oral Fibromas

Oral fibromas are benign tumors. Recurrence of oral fibromas is possible, however, if the offending irritant persists.

Ovarian Fibromas

Ovarian fibromas are almost always benign.

Ossifying Fibroma

Ossifying fibromas tend to regress over time. For locally aggressive lesions, surgical resection is often curative although recurrence has been reported. Ossifying fibroma is noninvasive tumor. It will recur if it is excised before skeletal maturity. Excision after skeletal maturity is usually successful.[34][35]

Pleural Fibroma

Chondromyxoid-Fibroma

Chondromyxoid-fibroma are benign lesions and malignant degeneration is rare. Chondromyxoid-fibromas have a high recurrence rate of approximately 25%.

Cemento-ossifying Fibroma

Recurrence following complete excision of cemento-ossifying fibroma is generally considered to be uncommon. However, in some series, it has been reported to be approximately 16%.

Desmoplastic Fibroma

Desmoplastic fibromas are benign and locally aggressive tumors. Desmoplastic fibroma is a rare benign intraosseous tumor neoplasm. It is usually a localized lesion with propensity for cortical bone perforation and recurrence. They are considered to be a bony counterpart of soft tissue desmoid tumors and are histologically identical. [3] Desmoplastic fibroma has a recurrence rate of approximately 37% to 72%. The average rate of recurrence after curettage has been reported to be approximately 55%.[1]

Sclerotic Fibroma

Sclerotic fibroma is an uncommon benign fibrous neoplasm and may be solitary or multifocal.

Uterine Fibroma

About 1 out of 1000 lesions are or become malignant, typically as a leiomyosarcoma on histology. A sign that a lesion may be malignant is growth after menopause. There are a number of rare conditions in which fibroids metastasize. They still grow in a benign fashion, but can be dangerous depending on their location.

Peripheral odontogenic fibroma

Recurrence is rare

Giant cell fibroma

Giant cell fibroma is a benign non-neoplastic lesion. Recurrence is rare.

References

  1. ↑ 1.0 1.1 1.2 Nedopil A, Raab P, Rudert M (2013). "Desmoplastic fibroma: a case report with three years of clinical and radiographic observation and review of the literature". Open Orthop J. 8: 40–6. doi:10.2174/1874325001307010040. PMC 3583030. PMID 23459513.
  2. ↑ 2.0 2.1 Biermann JS (2002). "Common benign lesions of bone in children and adolescents". J Pediatr Orthop. 22 (2): 268–73. PMID 11856945.
  3. ↑ 3.0 3.1 Cheng, A.; Ji, S.; Pogrel, M.A. (2012). "Poster 55: A Natural History of Desmoplastic Fibroma: Over 20 Years of Experience". Journal of Oral and Maxillofacial Surgery. 70 (9): e74. doi:10.1016/j.joms.2012.06.111. ISSN 0278-2391.
  4. ↑ Silvestre-Rangil, J.; Silvestre, FJ.; Requeni-Bernal, J. (2011). "Cemento-ossifying fibroma of the mandible: Presentation of a case and review of the literature". Journal of Clinical and Experimental Dentistry: e66–e69. doi:10.4317/jced.3.e66. ISSN 1989-5488.
  5. ↑ Hekmatnia A, Ghazavi A, Saboori M, Mahzouni P, Tayari N, Hekmatnia F (2011). "A case report of cemento-ossifying fibroma presenting as a mass of the ethmoid sinus". J Res Med Sci. 16 (2): 224–8. PMC 3214308. PMID 22091236.
  6. ↑ Naik RM, Guruprasad Y, Sujatha D, Gurudath S, Pai A, Suresh K (January 2014). "Giant cemento-ossifying fibroma of the mandible". J Nat Sci Biol Med. 5 (1): 190–4. doi:10.4103/0976-9668.127326. PMC 3961933. PMID 24678226.
  7. ↑ Jayachandran S, Meenakshi R (2004). "Cemento ossifying fibroma". Indian J Dent Res. 15 (1): 35–9. PMID 15682795.
  8. ↑ El-Mofty SK (November 1999). "Cemento-ossifying fibroma and benign cementoblastoma". Semin Diagn Pathol. 16 (4): 302–7. PMID 10587273.
  9. ↑ Dewan HS, Dewan SK, Bahl S, Tushar Parekh P (October 2016). "Cemento-ossifying fibroma of mandible mimicking complex composite odontome". BMJ Case Rep. 2016. doi:10.1136/bcr-2016-216053. PMC 5073669. PMID 27797795.
  10. ↑ Khalatbari, Mahmoud; Hamidi, Mehrdokht; Moharamzad, Yashar (2012). "Chondromyxoid Fibroma of the Anterior Skull Base Invading the Orbit in a Pediatric Patient: Case Report and Review of the Literature". Neuropediatrics. 43 (03): 140–145. doi:10.1055/s-0032-1307460. ISSN 0174-304X.
  11. ↑ E., Estrada-Villaseñor; E., Delgado Cedillo; G., Rico Martínez; R., Delgado Chávez (2005). "Periosteal chondromyxoid fibroma: A case study using imprint cytology". Diagnostic Cytopathology. 33 (6): 402–406. doi:10.1002/dc.20357. ISSN 8755-1039.
  12. ↑ McGrory BJ, Inwards CY, McLeod RA, Sim FH (1995). "Chondromyxoid fibroma". Orthopedics. 18 (3): 307–10. PMID 7761324.
  13. ↑ White PG, Saunders L, Orr W, Friedman L (1996). "Chondromyxoid fibroma". Skeletal Radiol. 25 (1): 79–81. PMID 8717127.
  14. ↑ Schutt PG, Frost HM (1971). "Chondromyxoid fibroma". Clin Orthop Relat Res. 78: 323–9. PMID 5110934.
  15. ↑ RALPH LL (1962). "Chondromyxoid fibroma of bone". J Bone Joint Surg Br. 44-B: 7–24. PMID 14038586.
  16. ↑ Regezi, Joseph A., James J. Sciubba, and Richard C. Jordan. Oral Pathology Clinical Pathologic Correlations. City: Elsevier Health Sciences, 2015. Print.
  17. ↑ Rangeeth, B. N., Joyson Moses, and Veera Kishore Kumar Reddy. "A rare presentation of mucocele and irritation fibroma of the lower lip." Contemporary clinical dentistry 1.2 (2010): 111.
  18. ↑ Vilmann, A., P. Vilmann, and H. Vilmann. "Pyogenic granuloma: evaluation of oral conditions." British journal of oral and Maxillofacial surgery 24.5 (1986): 376-382.
  19. ↑ Kolte, Abhay P., Rajshri A. Kolte, and Tushar S. Shrirao. "Focal fibrous overgrowths: A case series and review of literature." Contemporary clinical dentistry 1.4 (2010): 271.
  20. ↑ Schneider M, Zimmermann AC, Depprich RA, Kübler NR, Engers R, Naujoks CD, Handschel J (November 2009). "Desmoplastic fibroma of the mandible--review of the literature and presentation of a rare case". Head Face Med. 5: 25. doi:10.1186/1746-160X-5-25. PMC 2787487. PMID 19930688.
  21. ↑ Apaydin M, Gelal F, Avci A, Adinas C, Sarsilmaz A, Varer M (October 2008). "Desmoplastic fibroma in humerus". J Med Imaging Radiat Oncol. 52 (5): 489–90. doi:10.1111/j.1440-1673.2008.01989.x. PMID 19032395.
  22. ↑ Bowers LM, Cohen DM, Bhattacharyya I, Pettigrew JC, Stavropoulos MF (2013). "The non-ossifying fibroma: a case report and review of the literature". Head Neck Pathol. 7 (2): 203–10. doi:10.1007/s12105-012-0399-7. PMC 3642261. PMID 23008139.
  23. ↑ Sakamoto, Akio; Ishii, Takeaki; Oda, Yoshinao; Iwamoto, Yukihide (2012). "Nonossifying fibroma presenting as an aneurysmal bone cyst: a case report". Journal of Medical Case Reports. 6 (1): 407. doi:10.1186/1752-1947-6-407. ISSN 1752-1947.
  24. ↑ Bowers, Leah M.; Cohen, Donald M.; Bhattacharyya, Indraneel; Pettigrew, James C.; Stavropoulos, Mary F. (2012). "The Non-ossifying Fibroma: A Case Report and Review of the Literature". Head and Neck Pathology. 7 (2): 203–210. doi:10.1007/s12105-012-0399-7. ISSN 1936-055X.
  25. ↑ Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O (April 2016). "Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up". BMC Musculoskelet Disord. 17: 147. doi:10.1186/s12891-016-1004-0. PMC 4820930. PMID 27044378.
  26. ↑ Macciò A, Madeddu C, Kotsonis P, Pietrangeli M, Paoletti AM (June 2014). "Large twisted ovarian fibroma associated with Meigs' syndrome, abdominal pain and severe anemia treated by laparoscopic surgery". BMC Surg. 14: 38. doi:10.1186/1471-2482-14-38. PMC 4074309. PMID 24962423.
  27. ↑ Okuda K, Noguchi S, Narumoto O, Ikemura M, Yamauchi Y, Tanaka G, Takai D, Fukayama M, Nagase T (May 2016). "A case of Meigs' syndrome with preceding pericardial effusion in advance of pleural effusion". BMC Pulm Med. 16 (1): 71. doi:10.1186/s12890-016-0241-1. PMC 4862177. PMID 27160723.
  28. ↑ Kortekaas KE, Pelikan HM (January 2018). "Hydrothorax, ascites and an abdominal mass: not always signs of a malignancy - Three cases of Meigs' syndrome". J Radiol Case Rep. 12 (1): 17–26. doi:10.3941/jrcr.v12i1.3209. PMID 29875983.
  29. ↑ "Bleeding associated with uterine leiomyomas. Tailor treatment to the individual patient". Prescrire Int. 23 (149): 130–5. May 2014. PMID 24926520.
  30. ↑ Althobaiti FA, Alsaadi KK, Althobaiti AA (February 2019). "A Case of Hemoperitoneum Due to Spontaneous Bleeding from a Uterine Leiomyoma". Am J Case Rep. 20: 167–170. doi:10.12659/AJCR.914573. PMC 6375281. PMID 30733430.
  31. ↑ Mizrahi DJ, Kaushik C, Adamo R (March 2017). "Hypovolemic Shock and Hemoperitoneum from Spontaneous Avulsion of a Large Pedunculated Uterine Leiomyoma". J Radiol Case Rep. 11 (3): 15–21. doi:10.3941/jrcr.v11i3.3054. PMC 5441463. PMID 28584568.
  32. ↑ Pachy F, Lemercier D, Dommergues M, Sibony O (May 2009). "[Unusual complication of uterine leiomyoma: spontaneous avulsion with massive hemoperitoneum]". J Gynecol Obstet Biol Reprod (Paris) (in French). 38 (3): 239–41. doi:10.1016/j.jgyn.2008.08.008. PMID 19179018.
  33. ↑ Hicks G, McCallum IJ, Ogah K, Guirguis M, Kasaraneni R (February 2010). "Spontaneous uterine perforation secondary to uterine leiomyosarcoma presenting as acute abdomen with haemoperitoneum". J Obstet Gynaecol. 30 (2): 211–2. doi:10.3109/01443610903477523. PMID 20143996.
  34. ↑ McCaffrey M, Letts M, Carpenter B, Kabir A, Davidson D, Seip J (2003). "Osteofibrous dysplasia: a review of the literature and presentation of an additional 3 cases". Am J Orthop (Belle Mead NJ). 32 (10): 479–86. PMID 14620087.
  35. ↑ Wang JW, Shih CH, Chen WJ (1992). "Osteofibrous dysplasia (ossifying fibroma of long bones). A report of four cases and review of the literature". Clin Orthop Relat Res (278): 235–43. PMID 1563159.


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