Acinic cell carcinoma differential diagnosis: Difference between revisions

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Revision as of 13:31, 12 September 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD [2]

Overview

Differentiating acinic cell carcinoma from other Diseases

Differentiating acinic cell carcinoma from other diseases on the basis of histology findings

On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, Mammary analog secretory carcinoma.


	Histological findings
Diseases	Overlapping features	Distinguishing features
Salivary metastasis of thyroid carcinoma	Empty appearance, grooves, pseudoinclusions	Immunohistochemistry (Tyrogloubin)
salivary oncocytoma	Eosinophilic, non-serous cells	Hematoxylin
mucoepidermoid carcinoma	Microcystic, and follicula, inconspicuous mucous/squamoid cells, eosinophilic	Immunohistochemistry for p63
Mammary analoge secretory carcinoma	Histologically similar	Lack of PAS-positive secretory granules, Vimentin positive, Adipophilin positive

References

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@@ Line 11: / Line 11: @@
 ===Differentiating acinic cell carcinoma from other diseases on the basis of histology findings===
-On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as slivary metastasis of of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, mammary analogue secretory carcinoma.
+On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, Mammary analog secretory carcinoma.
-{|
-|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
+{| class="wikitable"
-! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
+|+
-! colspan="2" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
+!
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Over lapping features
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histological findings
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Distinguishing features
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |slivary metastasis of of thyroid carcinoma
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
+| style="background: #4479BA; color: #FFFFFF; text-align: center;" |Overlapping features
+| style="background: #4479BA; color: #FFFFFF; text-align: center;" |Distinguishing features
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |Salivary metastasis of thyroid carcinoma
 | style="background: #F5F5F5; padding: 5px;" |Empty appearance, grooves, pseudoinclusions
-| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry (tyrogloubin)
+| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry (Tyrogloubin)
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" |salivary oncocytoma
@@ Line 31: / Line 34: @@
 | style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry for p63
 |-
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |mammary analogue secretory carcinoma
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |Mammary analoge secretory carcinoma
 | style="background: #F5F5F5; padding: 5px;" |Histologically similar
-| style="background: #F5F5F5; padding: 5px;" |Lack of PAS-positive secretory granules, vimentin positive, adipophilin positive
+| style="background: #F5F5F5; padding: 5px;" |Lack of PAS-positive secretory granules, Vimentin positive, Adipophilin positive
 |-
 |}