Acinic cell carcinoma differential diagnosis: Difference between revisions
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===Differentiating acinic cell carcinoma from other diseases on the basis of histology findings=== | ===Differentiating acinic cell carcinoma from other diseases on the basis of histology findings=== | ||
On the basis of histologist findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma | On the basis of histologist findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, [[Oncocytoma|salivary oncocytoma]], [[mucoepidermoid carcinoma]], Mammary analog secretory carcinoma.<ref>{{cite journal|title=Tumors of the Salivary Glands, Atlas of Tumor Pathology: Third Series, Fascicle 17 G. L. Ellis and P. L. Auclair. Armed Forces Institute of Pathology, Washington D.C. ISBN: 1 881041 26 3 (Printed). 1996. Price: $69.00. ISBN: 1 881041 41 7 (CD-ROM). 1998. Price: $65.00|journal=The Journal of Pathology|volume=192|issue=4|year=2000|pages=564–565|issn=0022-3417|doi=10.1002/1096-9896(200012)192:4<564::AID-PATH737>3.0.CO;2-M}}</ref><ref name="Kumar2017">{{cite journal|last1=Kumar|first1=Uma|title=Acinic Cell Carcinoma Papillary-Cystic Variant: Diagnostic Pitfalls in Fine Needle Aspiration Cytology|journal=JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH|year=2017|issn=2249782X|doi=10.7860/JCDR/2017/21347.9772}}</ref> | ||
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Salivary gland tumor|Salivary]] [[metastasis]] of [[thyroid carcinoma]]<ref name="SamsGnepp2012">{{cite journal|last1=Sams|first1=Ralph N.|last2=Gnepp|first2=Douglas R.|title=P63 Expression Can Be Used in Differential Diagnosis of Salivary Gland Acinic Cell and Mucoepidermoid Carcinomas|journal=Head and Neck Pathology|volume=7|issue=1|year=2012|pages=64–68|issn=1936-055X|doi=10.1007/s12105-012-0403-2}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Salivary gland tumor|Salivary]] [[metastasis]] of [[thyroid carcinoma]]<ref name="SamsGnepp2012">{{cite journal|last1=Sams|first1=Ralph N.|last2=Gnepp|first2=Douglas R.|title=P63 Expression Can Be Used in Differential Diagnosis of Salivary Gland Acinic Cell and Mucoepidermoid Carcinomas|journal=Head and Neck Pathology|volume=7|issue=1|year=2012|pages=64–68|issn=1936-055X|doi=10.1007/s12105-012-0403-2}}</ref> | ||
| style="background: #F5F5F5; padding: 5px;" |Empty appearance, grooves, pseudoinclusions | | style="background: #F5F5F5; padding: 5px;" |Empty appearance, grooves, pseudoinclusions | ||
| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry ( | | style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry (''[[Thyroglobulin]]'') | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |salivary oncocytoma<ref name="SchwartzBegum2013">{{cite journal|last1=Schwartz|first1=Lauren E.|last2=Begum|first2=Shahnaz|last3=Westra|first3=William H.|last4=Bishop|first4=Justin A.|title=GATA3 Immunohistochemical Expression in Salivary Gland Neoplasms|journal=Head and Neck Pathology|volume=7|issue=4|year=2013|pages=311–315|issn=1936-055X|doi=10.1007/s12105-013-0442-3}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Oncocytoma|salivary oncocytoma]]<ref name="SchwartzBegum2013">{{cite journal|last1=Schwartz|first1=Lauren E.|last2=Begum|first2=Shahnaz|last3=Westra|first3=William H.|last4=Bishop|first4=Justin A.|title=GATA3 Immunohistochemical Expression in Salivary Gland Neoplasms|journal=Head and Neck Pathology|volume=7|issue=4|year=2013|pages=311–315|issn=1936-055X|doi=10.1007/s12105-013-0442-3}}</ref> | ||
| style="background: #F5F5F5; padding: 5px;" |Eosinophilic, non-serous cells | | style="background: #F5F5F5; padding: 5px;" |Eosinophilic, non-serous cells | ||
| style="background: #F5F5F5; padding: 5px;" |Hematoxylin | | style="background: #F5F5F5; padding: 5px;" |[[Hematoxylin]] | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |mucoepidermoid carcinoma<ref name="PatelSolomon20132">{{cite journal|last1=Patel|first1=Kalyani R.|last2=Solomon|first2=Isaac H.|last3=El-Mofty|first3=Samir K.|last4=Lewis|first4=James S.|last5=Chernock|first5=Rebecca D.|title=Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma|journal=Human Pathology|volume=44|issue=11|year=2013|pages=2501–2508|issn=00468177|doi=10.1016/j.humpath.2013.06.010}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[mucoepidermoid carcinoma]]<ref name="PatelSolomon20132">{{cite journal|last1=Patel|first1=Kalyani R.|last2=Solomon|first2=Isaac H.|last3=El-Mofty|first3=Samir K.|last4=Lewis|first4=James S.|last5=Chernock|first5=Rebecca D.|title=Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma|journal=Human Pathology|volume=44|issue=11|year=2013|pages=2501–2508|issn=00468177|doi=10.1016/j.humpath.2013.06.010}}</ref> | ||
| style="background: #F5F5F5; padding: 5px;" |Microcystic, and follicula, inconspicuous mucous/squamoid cells, eosinophilic | | style="background: #F5F5F5; padding: 5px;" |Microcystic, and [[Follicular Hyperkeratosis|follicula]], inconspicuous mucous/squamoid cells, [[eosinophilic]] | ||
| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry for p63 | | style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry for p63 | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Mammary analoge secretory carcinoma<ref name="pmid10421256">{{cite journal| author=Castle JT, Thompson LD, Frommelt RA, Wenig BM, Kessler HP| title=Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. | journal=Cancer | year= 1999 | volume= 86 | issue= 2 | pages= 207-19 | pmid=10421256 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10421256 }}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Mammary analoge secretory carcinoma<ref name="pmid10421256">{{cite journal| author=Castle JT, Thompson LD, Frommelt RA, Wenig BM, Kessler HP| title=Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. | journal=Cancer | year= 1999 | volume= 86 | issue= 2 | pages= 207-19 | pmid=10421256 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10421256 }}</ref> | ||
| style="background: #F5F5F5; padding: 5px;" |Histologically similar | | style="background: #F5F5F5; padding: 5px;" |Histologically similar | ||
| style="background: #F5F5F5; padding: 5px;" |Lack of PAS-positive secretory granules, Vimentin positive, Adipophilin positive | | style="background: #F5F5F5; padding: 5px;" |Lack of [[PAS stain|PAS-positive]] secretory granules, [[Vimentin]] positive, Adipophilin positive | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Acinic cell carcinoma is a head and neck tumor happening in the salivary glands. If a patient was observed with related signs, the tumor must be classified as a benign or invasive by the capsule being intact. Differential diagnosis of a malignant tumor in salivary gland is made after the incision and by histology features which will provide a good chemotherapy regimen for so called patients.
Differentiating acinic cell carcinoma from other Diseases
Differentiating acinic cell carcinoma from other diseases on the basis of histology findings
On the basis of histologist findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, Mammary analog secretory carcinoma.[1][2]
| Histological findings | ||
|---|---|---|
| Diseases | Overlapping features | Distinguishing features |
| Salivary metastasis of thyroid carcinoma[3] | Empty appearance, grooves, pseudoinclusions | Immunohistochemistry (Thyroglobulin) |
| salivary oncocytoma[4] | Eosinophilic, non-serous cells | Hematoxylin |
| mucoepidermoid carcinoma[5] | Microcystic, and follicula, inconspicuous mucous/squamoid cells, eosinophilic | Immunohistochemistry for p63 |
| Mammary analoge secretory carcinoma[6] | Histologically similar | Lack of PAS-positive secretory granules, Vimentin positive, Adipophilin positive |
References
- ↑ "Tumors of the Salivary Glands, Atlas of Tumor Pathology: Third Series, Fascicle 17 G. L. Ellis and P. L. Auclair. Armed Forces Institute of Pathology, Washington D.C. ISBN: 1 881041 26 3 (Printed). 1996. Price: $69.00. ISBN: 1 881041 41 7 (CD-ROM). 1998. Price: $65.00". The Journal of Pathology. 192 (4): 564–565. 2000. doi:10.1002/1096-9896(200012)192:4<564::AID-PATH737>3.0.CO;2-M. ISSN 0022-3417.
- ↑ Kumar, Uma (2017). "Acinic Cell Carcinoma Papillary-Cystic Variant: Diagnostic Pitfalls in Fine Needle Aspiration Cytology". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. doi:10.7860/JCDR/2017/21347.9772. ISSN 2249-782X.
- ↑ Sams, Ralph N.; Gnepp, Douglas R. (2012). "P63 Expression Can Be Used in Differential Diagnosis of Salivary Gland Acinic Cell and Mucoepidermoid Carcinomas". Head and Neck Pathology. 7 (1): 64–68. doi:10.1007/s12105-012-0403-2. ISSN 1936-055X.
- ↑ Schwartz, Lauren E.; Begum, Shahnaz; Westra, William H.; Bishop, Justin A. (2013). "GATA3 Immunohistochemical Expression in Salivary Gland Neoplasms". Head and Neck Pathology. 7 (4): 311–315. doi:10.1007/s12105-013-0442-3. ISSN 1936-055X.
- ↑ Patel, Kalyani R.; Solomon, Isaac H.; El-Mofty, Samir K.; Lewis, James S.; Chernock, Rebecca D. (2013). "Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma". Human Pathology. 44 (11): 2501–2508. doi:10.1016/j.humpath.2013.06.010. ISSN 0046-8177.
- ↑ Castle JT, Thompson LD, Frommelt RA, Wenig BM, Kessler HP (1999). "Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases". Cancer. 86 (2): 207–19. PMID 10421256.