Acinic cell carcinoma differential diagnosis: Difference between revisions
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! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Benign/ | ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Benign/ | ||
Malignant | Malignant | ||
! colspan=" | ! colspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestation | ||
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Paraclinical findings | ! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Paraclinical findings | ||
! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard diagnosis | ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard diagnosis | ||
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! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | ||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | ||
! | !Symptoms | ||
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs | ! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs | ||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab findings | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab findings | ||
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! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging | ||
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! align="center" style="background:#DCDCDC;" |[[Pleomorphic adenoma]]<ref name="pmid22190789">{{cite journal |vauthors=Debnath SC, Adhyapok AK |title=Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip |journal=J Maxillofac Oral Surg |volume=9 |issue=2 |pages=205–8 |date=June 2010 |pmid=22190789 |pmc=3244097 |doi=10.1007/s12663-010-0052-5 |url=}}</ref><ref name="pmid29845358">{{cite journal |vauthors=Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M |title=Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features |journal=Jpn J Radiol |volume=36 |issue=8 |pages=463–471 |date=August 2018 |pmid=29845358 |doi=10.1007/s11604-018-0747-y |url=}}</ref> | ! align="center" style="background:#DCDCDC;" |[[Pleomorphic adenoma]]<ref name="pmid22190789">{{cite journal |vauthors=Debnath SC, Adhyapok AK |title=Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip |journal=J Maxillofac Oral Surg |volume=9 |issue=2 |pages=205–8 |date=June 2010 |pmid=22190789 |pmc=3244097 |doi=10.1007/s12663-010-0052-5 |url=}}</ref><ref name="pmid29845358">{{cite journal |vauthors=Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M |title=Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features |journal=Jpn J Radiol |volume=36 |issue=8 |pages=463–471 |date=August 2018 |pmid=29845358 |doi=10.1007/s11604-018-0747-y |url=}}</ref> | ||
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Revision as of 12:29, 27 September 2019
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Acinic cell carcinoma Microchapters |
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Acinic cell carcinoma differential diagnosis On the Web |
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American Roentgen Ray Society Images of Acinic cell carcinoma differential diagnosis |
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Risk calculators and risk factors for Acinic cell carcinoma differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Acinic cell carcinoma is a head and neck tumor happening in the salivary glands. If a patient was observed with related signs, the tumor must be classified as a benign or invasive by the capsule being intact. Differential diagnosis of a malignant tumor in the salivary gland is made after the incision and by histology features which will provide a good chemotherapy regimen for so-called patients.
Differentiating acinic cell carcinoma from other Diseases
| Category | Diseases | Benign/
Malignant |
Clinical manifestation | Paraclinical findings | Gold standard diagnosis | Associated findings | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Demography | History | Symptoms | Signs | Lab findings | Histopathology | Imaging | |||||||
| Pleomorphic adenoma[1][2] |
|
|
− | + |
|
− | − |
|
− | ||||
| Warthin's tumor[3][4] |
|
|
− | + |
|
− | − |
|
− | ||||
| Oncocytoma |
|
|
± | ± |
|
|
|
|
|
- | |||
| Monomorphic adenoma [6][7][8] |
|
|
± | ± |
|
|
|
|
- | ||||
| Mucoepidermoid carcinoma |
|
|
± | ± |
|
|
− |
|
|
| |||
Differentiating acinic cell carcinoma from other diseases on the basis of histology findings
On the basis of histologist findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, Mammary analog secretory carcinoma.[10][11]
| Diseases | Histological findings | |
|---|---|---|
| Overlapping features | Distinguishing features | |
| Salivary metastasis of thyroid carcinoma[12] | Empty appearance, grooves, pseudoinclusions | Immunohistochemistry (Thyroglobulin) |
| salivary oncocytoma[13] | Eosinophilic, non-serous cells | Hematoxylin |
| mucoepidermoid carcinoma[14] | Microcystic, and follicula, inconspicuous mucous/squamoid cells, eosinophilic | Immunohistochemistry for p63 |
| Mammary analoge secretory carcinoma[15] | Histologically similar | Lack of PAS-positive secretory granules, Vimentin positive, Adipophilin positive |
References
- ↑ Debnath SC, Adhyapok AK (June 2010). "Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip". J Maxillofac Oral Surg. 9 (2): 205–8. doi:10.1007/s12663-010-0052-5. PMC 3244097. PMID 22190789.
- ↑ Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M (August 2018). "Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features". Jpn J Radiol. 36 (8): 463–471. doi:10.1007/s11604-018-0747-y. PMID 29845358.
- ↑ Chulam TC, Noronha Francisco AL, Goncalves Filho J, Pinto Alves CA, Kowalski LP (December 2013). "Warthin's tumour of the parotid gland: our experience". Acta Otorhinolaryngol Ital. 33 (6): 393–7. PMID 24376295.
- ↑ "Warthin tumor | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".
- ↑ Chen B, Hentzelman JI, Walker RJ, Lai JP (2016). "Oncocytoma of the Submandibular Gland: Diagnosis and Treatment Based on Clinicopathology". Case Rep Otolaryngol. 2016: 8719030. doi:10.1155/2016/8719030. PMC 5045990. PMID 27722003.
- ↑ Kim KH, Sung MW, Kim JW, Koo JW (July 2000). "Pleomorphic adenoma of the trachea". Otolaryngol Head Neck Surg. 123 (1 Pt 1): 147–8. doi:10.1067/mhn.2000.102809. PMID 10889498.
- ↑ Pramod Krishna B (June 2013). "Pleomorphic Adenoma of Minor Salivary Gland in a 14 year Old Child". J Maxillofac Oral Surg. 12 (2): 228–31. doi:10.1007/s12663-010-0125-5. PMC 3681990. PMID 24431845.
- ↑ Kessler AT, Bhatt AA (2018). "Review of the Major and Minor Salivary Glands, Part 2: Neoplasms and Tumor-like Lesions". J Clin Imaging Sci. 8: 48. doi:10.4103/jcis.JCIS_46_18. PMC 6251244. PMID 30546932.
- ↑ Chenevert J, Barnes LE, Chiosea SI (February 2011). "Mucoepidermoid carcinoma: a five-decade journey". Virchows Arch. 458 (2): 133–40. doi:10.1007/s00428-011-1040-y. PMID 21243374.
- ↑ "Tumors of the Salivary Glands, Atlas of Tumor Pathology: Third Series, Fascicle 17 G. L. Ellis and P. L. Auclair. Armed Forces Institute of Pathology, Washington D.C. ISBN: 1 881041 26 3 (Printed). 1996. Price: $69.00. ISBN: 1 881041 41 7 (CD-ROM). 1998. Price: $65.00". The Journal of Pathology. 192 (4): 564–565. 2000. doi:10.1002/1096-9896(200012)192:4<564::AID-PATH737>3.0.CO;2-M. ISSN 0022-3417.
- ↑ Kumar, Uma (2017). "Acinic Cell Carcinoma Papillary-Cystic Variant: Diagnostic Pitfalls in Fine Needle Aspiration Cytology". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. doi:10.7860/JCDR/2017/21347.9772. ISSN 2249-782X.
- ↑ Sams, Ralph N.; Gnepp, Douglas R. (2012). "P63 Expression Can Be Used in Differential Diagnosis of Salivary Gland Acinic Cell and Mucoepidermoid Carcinomas". Head and Neck Pathology. 7 (1): 64–68. doi:10.1007/s12105-012-0403-2. ISSN 1936-055X.
- ↑ Schwartz, Lauren E.; Begum, Shahnaz; Westra, William H.; Bishop, Justin A. (2013). "GATA3 Immunohistochemical Expression in Salivary Gland Neoplasms". Head and Neck Pathology. 7 (4): 311–315. doi:10.1007/s12105-013-0442-3. ISSN 1936-055X.
- ↑ Patel, Kalyani R.; Solomon, Isaac H.; El-Mofty, Samir K.; Lewis, James S.; Chernock, Rebecca D. (2013). "Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma". Human Pathology. 44 (11): 2501–2508. doi:10.1016/j.humpath.2013.06.010. ISSN 0046-8177.
- ↑ Castle JT, Thompson LD, Frommelt RA, Wenig BM, Kessler HP (1999). "Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases". Cancer. 86 (2): 207–19. PMID 10421256.