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==MRI==
==MRI==
*Brain MRI may be helpful in the diagnosis of subependymal giant cell astrocytoma. Findings on MRI suggestive of/diagnostic of subependymal giant cell astrocytoma include:<ref name="pmid26942030">{{cite journal| author=Stein JR, Reidman DA| title=Imaging Manifestations of a Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis. | journal=Case Rep Radiol | year= 2016 | volume= 2016 | issue=  | pages= 3750450 | pmid=26942030 | doi=10.1155/2016/3750450 | pmc=4752974 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26942030  }} </ref>
*Brain MRI may be helpful in the diagnosis of subependymal giant cell astrocytoma. Findings on MRI suggestive of/diagnostic of subependymal giant cell astrocytoma include:<ref name="pmid26942030">{{cite journal| author=Stein JR, Reidman DA| title=Imaging Manifestations of a Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis. | journal=Case Rep Radiol | year= 2016 | volume= 2016 | issue=  | pages= 3750450 | pmid=26942030 | doi=10.1155/2016/3750450 | pmc=4752974 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26942030  }} </ref><ref name="BeaumontGodzik2015">{{cite journal|last1=Beaumont|first1=Thomas L.|last2=Godzik|first2=Jakub|last3=Dahiya|first3=Sonika|last4=Smyth|first4=Matthew D.|title=Subependymal giant cell astrocytoma in the absence of tuberous sclerosis complex: case report|journal=Journal of Neurosurgery: Pediatrics|volume=16|issue=2|year=2015|pages=134–137|issn=1933-0707|doi=10.3171/2015.1.PEDS13146}}</ref>
:*Well circumscribed mass
:*Perilesional edema
:*T1 isointense and hypointense signal enhancement
:*T1 isointense and hypointense signal enhancement
:*T2 isointense and hyperintense signal enhancement
:*T2 isointense and hyperintense signal enhancement
:*Well circumscribed mass
:*Calcification
:*Calcification
:*Cyst
:*Cyst

Revision as of 17:50, 9 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Brain MRI is helpful in the diagnosis of subependymal giant cell astrocytoma. On MRI, subependymal giant cell astrocytoma is characterized by hypo- to isointensity on T1-weighted imaging and hyperintensity on T2-weighted imaging. There may be marked enhancement on contrast administration.[1]

MRI

  • Brain MRI may be helpful in the diagnosis of subependymal giant cell astrocytoma. Findings on MRI suggestive of/diagnostic of subependymal giant cell astrocytoma include:[2][3]
  • Well circumscribed mass
  • Perilesional edema
  • T1 isointense and hypointense signal enhancement
  • T2 isointense and hyperintense signal enhancement
  • Calcification
  • Cyst
  • Serial MRI every 1-3 years is recommended in asymptomatic patients younger than 25 as tumor growth is more common in these patients.[2]

Gallery

  • Two girls ([A] 9 and [B] 12 years old) with acute headaches and vomiting. On examination, both had papilledema. Brain magnetic resonance imaging shows ventricular subependymal giant cell astrocytomas with secondary hydrocephalus.[4]
    Two girls ([A] 9 and [B] 12 years old) with acute headaches and vomiting. On examination, both had papilledema. Brain magnetic resonance imaging shows ventricular subependymal giant cell astrocytomas with secondary hydrocephalus.[4]
  • This 6-year-old girl had a growing but asymptomatic tumor. (A) Her screening magnetic resonance imaging at age 2 revealed a subependymal giant cell astrocytoma with mild enlargement of the right lateral ventricle. (B) By age 6 years, the lesion had enlarged markedly.[4]
    This 6-year-old girl had a growing but asymptomatic tumor. (A) Her screening magnetic resonance imaging at age 2 revealed a subependymal giant cell astrocytoma with mild enlargement of the right lateral ventricle. (B) By age 6 years, the lesion had enlarged markedly.[4]
  • Subependymal giant cell astrocytoma of the type associated with tuberous sclerosis are typically bulky, contrast-enhancing mass in the region of the foramen of Monro. Most overlie the head of the caudate nucleus. Foramen obstruction has produced hydrocephalus.[5]
    Subependymal giant cell astrocytoma of the type associated with tuberous sclerosis are typically bulky, contrast-enhancing mass in the region of the foramen of Monro. Most overlie the head of the caudate nucleus. Foramen obstruction has produced hydrocephalus.[5]

References

  1. ↑ Radiographic MRI features of subependymal giant cell astrocytoma. Dr Bruno Di Muzio and Dr Jeremy Jones et al. Radiopaedia 2015. http://radiopaedia.org/articles/subependymal-giant-cell-astrocytoma. Accessed on November 4, 2015
  2. ↑ 2.0 2.1 Stein JR, Reidman DA (2016). "Imaging Manifestations of a Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis". Case Rep Radiol. 2016: 3750450. doi:10.1155/2016/3750450. PMC 4752974. PMID 26942030.
  3. ↑ Beaumont, Thomas L.; Godzik, Jakub; Dahiya, Sonika; Smyth, Matthew D. (2015). "Subependymal giant cell astrocytoma in the absence of tuberous sclerosis complex: case report". Journal of Neurosurgery: Pediatrics. 16 (2): 134–137. doi:10.3171/2015.1.PEDS13146. ISSN 1933-0707.
  4. ↑ 4.0 4.1 Roth, Jonathan; Roach, E. Steve; Bartels, Ute; Jóźwiak, Sergiusz; Koenig, Mary Kay; Weiner, Howard L.; Franz, David N.; Wang, Henry Z. (2013). "Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012". Pediatric Neurology. 49 (6): 439–444. doi:10.1016/j.pediatrneurol.2013.08.017. ISSN 0887-8994.
  5. ↑ Radiology features of subependymal giant cell astrocytoma. Libre pathology 2015. http://librepathology.org/wiki/index.php/Subependymal_giant_cell_astrocytoma. Accessed on November 2, 2015


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