Subependymal giant cell astrocytoma history and symptoms: Difference between revisions
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===Common Symptoms=== | ===Common Symptoms=== | ||
Majority of the symptoms experienced by patients with subependymal giant cell astrocytoma are due to obstruction of the foramen of monroe. | Majority of the symptoms experienced by patients with subependymal giant cell astrocytoma are due to obstruction of the foramen of monroe. Common symptoms of subependymal giant cell astrocytoma include:<ref name="pmid23391693">{{cite journal| author=Jóźwiak S, Nabbout R, Curatolo P, participants of the TSC Consensus Meeting for SEGA and Epilepsy Management| title=Management of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC): Clinical recommendations. | journal=Eur J Paediatr Neurol | year= 2013 | volume= 17 | issue= 4 | pages= 348-52 | pmid=23391693 | doi=10.1016/j.ejpn.2012.12.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23391693 }} </ref><ref name="OuyangZhang2014">{{cite journal|last1=Ouyang|first1=Taohui|last2=Zhang|first2=Na|last3=Benjamin|first3=Thomas|last4=Wang|first4=Long|last5=Jiao|first5=Jiantong|last6=Zhao|first6=Yiqing|last7=Chen|first7=Jian|title=Subependymal giant cell astrocytoma: current concepts, management, and future directions|journal=Child's Nervous System|volume=30|issue=4|year=2014|pages=561–570|issn=0256-7040|doi=10.1007/s00381-014-2383-x}}</ref><ref name=symptomsofsegafghfh>Symptoms of subependymal giant cell astrocytoma. University of Pittsburgh Medical Center 2015. http://www.upmc.com/services/neurosurgery/brain/conditions/brain-tumors/pages/subependymal-giant-cell-astrocytoma.aspx. Accessed on November 5, 2015</ref><ref name="pmid18952591">{{cite journal| author=Koenig MK, Butler IJ, Northrup H| title=Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex. | journal=J Child Neurol | year= 2008 | volume= 23 | issue= 10 | pages= 1238-9 | pmid=18952591 | doi=10.1177/0883073808321764 | pmc=3072698 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18952591 }} </ref><ref name="pmid15505165">{{cite journal| author=Goh S, Butler W, Thiele EA| title=Subependymal giant cell tumors in tuberous sclerosis complex. | journal=Neurology | year= 2004 | volume= 63 | issue= 8 | pages= 1457-61 | pmid=15505165 | doi=10.1212/01.wnl.0000142039.14522.1a | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15505165 }} </ref> | ||
*[[Headaches]] | *[[Headaches]] | ||
*[[Nausea]] | *[[Nausea]] | ||
| Line 26: | Line 26: | ||
*New onset seizures | *New onset seizures | ||
*Worsening of seizure control | *Worsening of seizure control | ||
*[[Personality pathology|Personality changes]] | *[[Personality pathology|Personality changes]] | ||
*Fatigue | *Fatigue | ||
*Decreased appetite | *Decreased appetite | ||
| Line 36: | Line 32: | ||
===Less Common Symptoms=== | ===Less Common Symptoms=== | ||
Less common symptoms of subependymal giant cell astrocytoma include: | Less common symptoms of subependymal giant cell astrocytoma include:<ref name="pmid23391693">{{cite journal| author=Jóźwiak S, Nabbout R, Curatolo P, participants of the TSC Consensus Meeting for SEGA and Epilepsy Management| title=Management of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC): Clinical recommendations. | journal=Eur J Paediatr Neurol | year= 2013 | volume= 17 | issue= 4 | pages= 348-52 | pmid=23391693 | doi=10.1016/j.ejpn.2012.12.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23391693 }} </ref><ref name="OuyangZhang2014">{{cite journal|last1=Ouyang|first1=Taohui|last2=Zhang|first2=Na|last3=Benjamin|first3=Thomas|last4=Wang|first4=Long|last5=Jiao|first5=Jiantong|last6=Zhao|first6=Yiqing|last7=Chen|first7=Jian|title=Subependymal giant cell astrocytoma: current concepts, management, and future directions|journal=Child's Nervous System|volume=30|issue=4|year=2014|pages=561–570|issn=0256-7040|doi=10.1007/s00381-014-2383-x}}</ref><ref name=symptomsofsegafghfh>Symptoms of subependymal giant cell astrocytoma. University of Pittsburgh Medical Center 2015. http://www.upmc.com/services/neurosurgery/brain/conditions/brain-tumors/pages/subependymal-giant-cell-astrocytoma.aspx. Accessed on November 5, 2015</ref><ref name="pmid18952591">{{cite journal| author=Koenig MK, Butler IJ, Northrup H| title=Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex. | journal=J Child Neurol | year= 2008 | volume= 23 | issue= 10 | pages= 1238-9 | pmid=18952591 | doi=10.1177/0883073808321764 | pmc=3072698 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18952591 }} </ref><ref name="pmid15505165">{{cite journal| author=Goh S, Butler W, Thiele EA| title=Subependymal giant cell tumors in tuberous sclerosis complex. | journal=Neurology | year= 2004 | volume= 63 | issue= 8 | pages= 1457-61 | pmid=15505165 | doi=10.1212/01.wnl.0000142039.14522.1a | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15505165 }} </ref> | ||
*Vision loss | *Vision loss | ||
*Sleep disorder | *Sleep disorder | ||
*Memory loss | *Memory loss | ||
*Changes in speech | |||
*Weakness in limbs | |||
*Sensory loss | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
When evaluating a patient for subependymal giant cell astrocytoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough family and past medical history review. Other specific areas of focus when obtaining the history include review of common associated conditions such as tuberous sclerosis.[1] Symptoms of subependymal giant cell astrocytoma include headache, seizures, vision loss, changes in speech, weakness in limbs, and sensory loss.[2][3][4]
History and Symptoms
History
Patients with subependymal giant cell astrocytoma may have a positive history of:[2][3][4][5][6]
- Genetic disorders such as:
- Tuberous sclerosis
- Headache
- Nausea
- Vomiting
- Seizures
- Memory loss
- Personality change
Common Symptoms
Majority of the symptoms experienced by patients with subependymal giant cell astrocytoma are due to obstruction of the foramen of monroe. Common symptoms of subependymal giant cell astrocytoma include:[2][3][4][5][6]
- Headaches
- Nausea
- Vomiting
- Diplopia
- New onset seizures
- Worsening of seizure control
- Personality changes
- Fatigue
- Decreased appetite
- Cognitive decline
Less Common Symptoms
Less common symptoms of subependymal giant cell astrocytoma include:[2][3][4][5][6]
- Vision loss
- Sleep disorder
- Memory loss
- Changes in speech
- Weakness in limbs
- Sensory loss
References
- ↑ Roth, Jonathan; Roach, E. Steve; Bartels, Ute; Jóźwiak, Sergiusz; Koenig, Mary Kay; Weiner, Howard L.; Franz, David N.; Wang, Henry Z. (2013). "Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012". Pediatric Neurology. 49 (6): 439–444. doi:10.1016/j.pediatrneurol.2013.08.017. ISSN 0887-8994.
- ↑ 2.0 2.1 2.2 2.3 Jóźwiak S, Nabbout R, Curatolo P, participants of the TSC Consensus Meeting for SEGA and Epilepsy Management (2013). "Management of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC): Clinical recommendations". Eur J Paediatr Neurol. 17 (4): 348–52. doi:10.1016/j.ejpn.2012.12.008. PMID 23391693.
- ↑ 3.0 3.1 3.2 3.3 Ouyang, Taohui; Zhang, Na; Benjamin, Thomas; Wang, Long; Jiao, Jiantong; Zhao, Yiqing; Chen, Jian (2014). "Subependymal giant cell astrocytoma: current concepts, management, and future directions". Child's Nervous System. 30 (4): 561–570. doi:10.1007/s00381-014-2383-x. ISSN 0256-7040.
- ↑ 4.0 4.1 4.2 4.3 Symptoms of subependymal giant cell astrocytoma. University of Pittsburgh Medical Center 2015. http://www.upmc.com/services/neurosurgery/brain/conditions/brain-tumors/pages/subependymal-giant-cell-astrocytoma.aspx. Accessed on November 5, 2015
- ↑ 5.0 5.1 5.2 Koenig MK, Butler IJ, Northrup H (2008). "Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex". J Child Neurol. 23 (10): 1238–9. doi:10.1177/0883073808321764. PMC 3072698. PMID 18952591.
- ↑ 6.0 6.1 6.2 Goh S, Butler W, Thiele EA (2004). "Subependymal giant cell tumors in tuberous sclerosis complex". Neurology. 63 (8): 1457–61. doi:10.1212/01.wnl.0000142039.14522.1a. PMID 15505165.