Primary amyloidosis causes: Difference between revisions
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==Overview== | ==Overview== | ||
The cause of AL amyloidosis is usually a plasma cell dyscrasia, an acquired abnormality of the plasma cell in the bone marrow with production of an abnormal light chain protein (a component of an antibody). | The cause of AL amyloidosis is usually a [[plasma cell dyscrasia]], an acquired abnormality of the [[plasma cell]] in the [[bone marrow]] with production of an abnormal [[Light chain|light chain protein]] (a component of an [[antibody]]). | ||
==Causes== | ==Causes== | ||
* The cause of AL amyloidosis is usually a plasma cell dyscrasia, an acquired abnormality of the plasma cell in the bone marrow with production of an abnormal light chain protein (a component of an antibody). | * The cause of AL amyloidosis is usually a [[plasma cell dyscrasia]], an acquired abnormality of the [[plasma cell]] in the [[bone marrow]] with production of an abnormal [[Light chain|light chain protein]] (a component of an [[antibody]]). | ||
* The increased production of plasma cell | * The increased production of [[plasma cell]] [[clone]] leads to [[Extracellular|extra-cellular]] deposition of [[fibril]]-forming [[monoclonal]] [[immunoglobulin]] (Ig) [[Light chain|light chains]] (LC) (most commonly of lambda [[Isotype (immunology)|isotype]]) | ||
* Typically, an excess amount of antibody protein is produced and the abnormal light chain portion or the whole antibody molecule accumulates in the organs in the form of amyloid deposits. | * Typically, an excess amount of [[antibody]] [[protein]] is produced and the abnormal [[light chain]] portion or the whole [[antibody]] molecule accumulates in the [[Organ (anatomy)|organs]] in the form of [[amyloid]] deposits. | ||
==References== | ==References== | ||
Latest revision as of 17:32, 30 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
The cause of AL amyloidosis is usually a plasma cell dyscrasia, an acquired abnormality of the plasma cell in the bone marrow with production of an abnormal light chain protein (a component of an antibody).
Causes
- The cause of AL amyloidosis is usually a plasma cell dyscrasia, an acquired abnormality of the plasma cell in the bone marrow with production of an abnormal light chain protein (a component of an antibody).
- The increased production of plasma cell clone leads to extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig) light chains (LC) (most commonly of lambda isotype)
- Typically, an excess amount of antibody protein is produced and the abnormal light chain portion or the whole antibody molecule accumulates in the organs in the form of amyloid deposits.