Primary amyloidosis differential diagnosis: Difference between revisions
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Hypertrophic obstructive cardiomyopathy | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Hypertrophic obstructive cardiomyopathy | ||
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* Mutation in sarcomeric protein (beta myosin heavy chain and myosin binding protein C) | |||
* Autosomal dominant inheritance | |||
* | * | ||
* | * | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" |<br /> | ||
* [[Chest pain]] (also known as [[Angina pectoris|angina]]) | |||
* [[Dizziness]] | |||
* [[Dyspnea]] ([[shortness of breath]]) which is due to increased stiffness of the [[hypertrophied left ventricle]] | |||
* [[Exercise intolerance]] | |||
* [[Fainting]], [[presyncope]] or frank [[syncope]], especially during exercise | |||
* [[Fatigue]]) | |||
* [[Light-headedness]] | |||
* [[Shortness of breath]] | |||
* [[Reduced activity tolerance]] | |||
* [[Shortness of breath]] | |||
* [[Sudden cardiac death]] | |||
<br /> | |||
** | ** | ||
** | ** | ||
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* Increased BNP | |||
* Increased creatine kinase | |||
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* Echocardiography: | |||
** [[Left ventricular]] asymmetric hypertrophy | |||
** Parasternal long axis shows relationship of the septal hypertrophy and the outflow tract | |||
** Left ventricular diastolic dysfunction | |||
** SAM (systolic anterior motion) of the mitral leaflet | |||
** Mid-systolic closure of the aortic valve | |||
** Late peaking, high velocity flow in the outflow tract | |||
** Variability of obstruction with maneuvers (exercise, amyl nitrate inhalation, and post-PVC beats) <br /> | |||
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* [[Beta blockers]] | |||
* [[Calcium channel blocker|Calcium channel blockers]] | |||
* [[Septal myectomy]] | |||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Alcoholic cardiomyopathy | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Alcoholic cardiomyopathy |
Revision as of 19:14, 30 October 2019
Primary amyloidosis Microchapters |
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Primary amyloidosis differential diagnosis On the Web |
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Risk calculators and risk factors for Primary amyloidosis differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
- Differentiating Primary amyloidosis from Other Diseases
Organ System Involvement | Differential Diagnosis | Causes | Clinical Features | Laboratory Findings | Gold Standard Test | Therapy |
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Nephrotic Syndrome and Real Failure | Primary (AL) Amyloidosis |
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Diabetic Nephropathy |
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Minimal Change Disease |
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Focal Segmental Glomerulosclerosis |
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Fabry's Disease |
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Light Chain Deposition Disease |
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Membranous Glomerulonephritis |
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Fibrillary-Immunotactoid Glomerulopathy |
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Organ System Involvement | Differential Diagnosis | Causes | Clinical Features | Laboratory Findings | Gold Standard Test | Therapy |
Polyneuropathy | POEMS syndrome (Demyelinating) |
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Metabolic Syndrome (Axonal pathology) |
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Vitamin Deficiencies (Axonal Pathology) |
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Guillain-Barre Syndrome (Demyelinating) |
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Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (Mixed axonal and demyelinatiing) |
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Multifocal Motor Neuropathy |
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Organ System Involvement | Differential Diagnosis | Causes | Features | Laboratory Findings | Gold Standard Test | Therapy |
Organomegaly (Hepatosplenomegaly and Lymphadenopathy) | Malaria |
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Kala-azar |
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Infective Hepatitis |
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Chronic Myelogenous Leukemia (CML) |
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Lymphoma |
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Primary (AL) Amyloidosis |
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Gaucher's Disease |
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Organ System Involvement | Differential Diagnosis | Causes | Features | Laboratory Findings | Gold Standard Test | Therapy |
Cardiac Failure | Cardiac amyloidosis (AL and ATTRwt) |
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Hypertrophic obstructive cardiomyopathy |
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Alcoholic cardiomyopathy |
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ST-elevation myocardial infarction |
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Pericarditis |
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Non-ST-segment elevation myocardial infarction |
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Organ System Involvement | Differential Diagnosis | Causes | Features | Laboratory Findings | Gold Standard Test | Therapy |
Plasma Cell Dyscrasias | Multiple myeloma |
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AND
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Monoclonal gammopathy of undetermined significance (MGUS) |
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AND
AND
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Asymptomatic Plasma Cell Myeloma |
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OR
AND/OR
AND
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Plasmacytoma |
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Skin Changes | Scurvy |
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