Beriberi laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* Measurement of [[erythrocyte transketolase activity]] ([[ETKA]]) and the [[thiamine pyrophosphate effect]] ([[TPPE]]) are sensitive tests for thiamine deficiency. | * The diagnosis of beriberi is assisted by a dietary history suggestive of a low thiamine intake and clinical manifestations. | ||
* Other tests include measurements of urinary concetrations of thiamine and its metabolites, as well as methylglyoxal. | |||
* However, objective biochemical tests of thiamine status may assist with diagnosis.<ref name="pmid25564426">{{cite journal| author=Frank LL| title=Thiamin in Clinical Practice. | journal=JPEN J Parenter Enteral Nutr | year= 2015 | volume= 39 | issue= 5 | pages= 503-20 | pmid=25564426 | doi=10.1177/0148607114565245 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25564426 }}</ref> | |||
** Measurement of [[erythrocyte transketolase activity]] ([[ETKA]]) and the [[thiamine pyrophosphate effect]] ([[TPPE]]) are sensitive tests for thiamine deficiency. | |||
** Other tests include measurements of urinary concetrations of thiamine and its metabolites, as well as methylglyoxal. | |||
==References== | ==References== | ||
Revision as of 19:22, 11 November 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]
Overview
The most sensitive lab tests to detect thiamine deficiency are measurements of erythrocyte transketolase activity (ETKA) and the thiamine pyrophosphate effect (TPPE).
Laboratory Findings
- The diagnosis of beriberi is assisted by a dietary history suggestive of a low thiamine intake and clinical manifestations.
- However, objective biochemical tests of thiamine status may assist with diagnosis.[1]
- Measurement of erythrocyte transketolase activity (ETKA) and the thiamine pyrophosphate effect (TPPE) are sensitive tests for thiamine deficiency.
- Other tests include measurements of urinary concetrations of thiamine and its metabolites, as well as methylglyoxal.
References
- ↑ Frank LL (2015). "Thiamin in Clinical Practice". JPEN J Parenter Enteral Nutr. 39 (5): 503–20. doi:10.1177/0148607114565245. PMID 25564426.