Central pontine myelinolysis history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

spastic quadriparesis, dysarthria, pseudobulbar palsy, and altered mental status. In some patients, parkinsonian features, behavioral manifestations, and neuropsychological symptoms can also be present

behavioral manifestations (personality changes, labile affect, disinhibition, poor judgment, paranoid delusions, emotional lability, delirium, hallucinations, and catatonia)

History and Symptoms

History

Patients with central pontine myelinolysis may have a positive history of:

• Malnutrition
• Alcohol use disorder
• Chronic liver disease
• Hyperemesis gravidarum
• Hypophosphatemia secondary to refeeding syndrome
• Prolonged ischemia

These patients with central pontine myelinolysis most commonly have a history of rapid sodium correction, greater than 0.5-1.0 mEq/L per hour.

The most susceptible patients are those with:

• Chronic hyponatremia (>48 hours)

• Severe hyponatremia (Na <120 mEq/L)
• Both Chronic hyponatremia and severe hyponatremia

Common Symptoms

Common symptoms of [disease] include:

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Less Common Symptoms

Less common symptoms of [disease name] include

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• [Symptom 2]
• [Symptom 3]