Central pontine myelinolysis history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
===History=== | ===History=== | ||
Patients with central pontine myelinolysis may have a positive history of: | Patients with central pontine myelinolysis may have a positive history of:<ref name="pmid29295827">{{cite journal| author=Seliger S, Kestenbaum B| title=Commentary on Treatment of Severe Hyponatremia. | journal=Clin J Am Soc Nephrol | year= 2018 | volume= 13 | issue= 4 | pages= 650-651 | pmid=29295827 | doi=10.2215/CJN.13381217 | pmc=5969468 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29295827 }} </ref><ref name="pmid15300900">{{cite journal| author=Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH| title=Possible causes of central pontine myelinolysis after liver transplantation. | journal=World J Gastroenterol | year= 2004 | volume= 10 | issue= 17 | pages= 2540-3 | pmid=15300900 | doi=10.3748/wjg.v10.i17.2540 | pmc=4572157 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15300900 }} </ref> | ||
*[[Malnutrition]] | *[[Malnutrition]] | ||
*[[Alcohol abuse|Alcohol use disorder]] | *[[Alcohol abuse|Alcohol use disorder]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
spastic quadriparesis, dysarthria, pseudobulbar palsy, and altered mental status. In some patients, parkinsonian features, behavioral manifestations, and neuropsychological symptoms can also be present
behavioral manifestations (personality changes, labile affect, disinhibition, poor judgment, paranoid delusions, emotional lability, delirium, hallucinations, and catatonia)
History and Symptoms
History
Patients with central pontine myelinolysis may have a positive history of:[1][2]
- Malnutrition
- Alcohol use disorder
- Chronic liver disease
- Hyperemesis gravidarum
- Hypophosphatemia secondary to refeeding syndrome
- Prolonged ischemia
These patients with central pontine myelinolysis most commonly have a history of rapid sodium correction, greater than 0.5-1.0 mEq/L per hour.
The most susceptible patients are those with:
- Chronic hyponatremia (>48 hours)
- Severe hyponatremia (Na <120 mEq/L)
- Both Chronic hyponatremia and severe hyponatremia
Common Symptoms
Common symptoms of [disease] include:
- [Symptom 1]
- [Symptom 2]
- [Symptom 3]
Less Common Symptoms
Less common symptoms of [disease name] include
- [Symptom 1]
- [Symptom 2]
- [Symptom 3]
References
- ↑ Seliger S, Kestenbaum B (2018). "Commentary on Treatment of Severe Hyponatremia". Clin J Am Soc Nephrol. 13 (4): 650–651. doi:10.2215/CJN.13381217. PMC 5969468. PMID 29295827.
- ↑ Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH (2004). "Possible causes of central pontine myelinolysis after liver transplantation". World J Gastroenterol. 10 (17): 2540–3. doi:10.3748/wjg.v10.i17.2540. PMC 4572157. PMID 15300900.