Thoracic aortic aneurysm causes: Difference between revisions
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===Syndromic Causes=== | ===Syndromic Causes=== | ||
*[[Marfan's syndrome]]: Aortic root dilation with or without associated [[aortic regurgitation]] occurs in 75%-80% of marfan's patients. | *[[Marfan's syndrome]]: Aortic root dilation with or without associated [[aortic regurgitation]] occurs in 75%-80% of marfan's patients<ref name="pmid27274304">{{cite journal |vauthors=Pepe G, Giusti B, Sticchi E, Abbate R, Gensini GF, Nistri S |title=Marfan syndrome: current perspectives |journal=Appl Clin Genet |volume=9 |issue= |pages=55–65 |date=2016 |pmid=27274304 |pmc=4869846 |doi=10.2147/TACG.S96233 |url=}}</ref>. | ||
*[[Loeys-Dietz syndrome]] | *[[Loeys-Dietz syndrome]] | ||
*[[Ehlers-Danlos syndrome]] | *[[Ehlers-Danlos syndrome]] | ||
Revision as of 21:39, 29 December 2019
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Thoracic aortic aneurysm Microchapters |
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Differentiating Thoracic Aortic Aneurysm from other Diseases |
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Diagnosis |
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Treatment |
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Special Scenarios |
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Case Studies |
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Thoracic aortic aneurysm causes On the Web |
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Directions to Hospitals Treating Thoracic aortic aneurysm causes |
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Risk calculators and risk factors for Thoracic aortic aneurysm causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2] Mohammad Salih, MD.
Overview
Two of the most common causes of thoracic aorta aneurysm are Marfan's syndrome and atherosclerosis. In some centers, a prior history of dissection with aneurysmal dilation is the most common cause of surgical repair.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
Causes by Organ System
| Cardiovascular | Aortic dissection, aortic stenosis, aortic valve replacement, aortitis, atherosclerosis, bacterial endocarditis, bicuspid aortic valve, systemic hypertension |
| Chemical / poisoning | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Arterial tortuosity syndrome, bicuspid aortic valve, Ehlers-Danlos syndrome, familial thoracic aortic aneurysms and dissections, Loeys-Dietz syndrome, Marfan syndrome, Turner syndrome |
| Hematologic | No underlying causes |
| Iatrogenic | Previous surgery on the aorta |
| Infectious Disease | Aortitis, quaternary syphilis, septic embolism |
| Musculoskeletal / Ortho | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional / Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Opthalmologic | No underlying causes |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | Wegener's granulomatosis |
| Renal / Electrolyte | No underlying causes |
| Rheum / Immune / Allergy | Ankylosing spondylitis, aortitis, Behcet's disease, giant cell arteritis, reactive arthritis, rheumatoid arthritis, rheumatoid vasculitis, Takayasu's arteritis, Wegener's granulomatosis |
| Sexual | No underlying causes |
| Trauma | Sudden deceleration |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
- Ankylosing spondylitis
- Aortic dissection
- Aortic stenosis
- Aortitis
- Aortic valve replacement
- Arterial tortuosity syndrome
- Atherosclerosis
- Bacterial infection, often following valvular endocarditis
- Behcet's disease
- Bicuspid aortic valve
- Ehlers-Danlos syndrome
- Familial thoracic aortic aneurysms and dissections
- Giant cell arteritis
- Loeys-Dietz syndrome
- Marfan's syndrome
- Quaternary syphilis
- Reactive arthritis
- Rheumatoid arthritis
- Rheumatoid vasculitis
- Septic embolism
- Systemic hypertension
- Takayasu's arteritis
- Temporal arteritis
- Traumatic - Sudden deceleration
- Turner's syndrome
- Wegener's granulomatosis
Causes Based Upon Inherited versus Sporadic versus Syndromic Basis
Sporadic Causes
- Ankylosing spondylitis
- Atherosclerosis
- Bacterial infection, often following valvular endocarditis
- Behcet's disease
- Giant cell arteritis
- Previous injury to the aorta such as an aortic dissection
- Syphilis
- Takayasu's arteritis
- Traumatic - sudden deceleration
Familial Causes
- Familial thoracic aortic aneurysms and dissections[2]
- Bicuspid aortic valve with post-stenotic dilation due to turbulence[3]
Syndromic Causes
- Marfan's syndrome: Aortic root dilation with or without associated aortic regurgitation occurs in 75%-80% of marfan's patients[4].
- Loeys-Dietz syndrome
- Ehlers-Danlos syndrome
- Turner's syndrome
References
- ↑ Cheung K, Boodhwani M, Chan KL, Beauchesne L, Dick A, Coutinho T (February 2017). "Thoracic Aortic Aneurysm Growth: Role of Sex and Aneurysm Etiology". J Am Heart Assoc. 6 (2). doi:10.1161/JAHA.116.003792. PMC 5523737. PMID 28159818.
- ↑ Isselbacher EM, Lino Cardenas CL, Lindsay ME (June 2016). "Hereditary Influence in Thoracic Aortic Aneurysm and Dissection". Circulation. 133 (24): 2516–28. doi:10.1161/CIRCULATIONAHA.116.009762. PMC 5031368. PMID 27297344.
- ↑ Norton E, Yang B (2017). "Managing Thoracic Aortic Aneurysm in Patients with Bicuspid Aortic Valve Based on Aortic Root-Involvement". Front Physiol. 8: 397. doi:10.3389/fphys.2017.00397. PMC 5469203. PMID 28659818.
- ↑ Pepe G, Giusti B, Sticchi E, Abbate R, Gensini GF, Nistri S (2016). "Marfan syndrome: current perspectives". Appl Clin Genet. 9: 55–65. doi:10.2147/TACG.S96233. PMC 4869846. PMID 27274304.