Paget-Schroetter disease overview: Difference between revisions
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Revision as of 14:53, 21 June 2020
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Paget-Schroetter disease Microchapters |
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Differentiating Paget-Schroetter disease from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Paget-Schroetter disease overview On the Web |
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American Roentgen Ray Society Images of Paget-Schroetter disease overview |
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Risk calculators and risk factors for Paget-Schroetter disease overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Historical Perspective
Spontaneous axillary-subclavian vein thrombosis (ASVT) has been first described by Cruveilhier. Sir James Paget identified the subclavian vein thrombosis in one of his patients. Hughes created the term "Paget-Schroetter".
Classification
There is no established system for the classification of Paget-Schroetter disease.
Pathophysiology
It is thought that Paget-Schroetter disease is a form of axillary-subclavian vein thrombosis resulted from compression of aforementioned veins. This condition is more common in athletes and/or manual labors. Some studies link Paget-Schroetter disease with anatomical defects involving the thoracic outlet.
Causes
Common causes of Paget-Schroetter disease include a repetitious activity of upper extremity, hypertrophied scalenus anterior muscle, presence of osseous exostosis, congenital deformities, and major vein catheterization.
Differentiating Paget-Schroetter disease from Other Diseases
Since early diagnosing and treatment of Paget-Schroetter disease is crucial to halt fatal complications like pulmonary embolism, it is important to differentiate it from other diseases with similar presentations and findings.
Epidemiology and Demographics
Paget-Schroetter disease usually affects young individuals. The incidence of Paget-Schroetter disease is roughly 2.03 per 100,000 people per year.Men are more commonly affected by Paget-Schroetter disease than women.
Risk Factors
Common risk factors in the development of Paget-Schroetter include repetitive upper extremity, overdeveloped anterior scalene muscle, congenital bands between the first and second rib and thoracic outlet syndrome.
Screening
There is insufficient evidence to recommend routine screening for Paget-Schroetter disease.
Natural History, Complications, and Prognosis
The symptoms of Paget-Schroetter syndrome usually develop in the forth decade of life. Common complications include pulmonary embolism, recurrent thrombosis, superior vena cava syndrome and sepsis. Patients with early diagnosis and proper treatments usually have good prognosis.
Diagnosis
Diagnostic Study of Choice
History and Symptoms
A positive history of repetitive upper extremity movements in a patient presenting with arm discomfort and edema is suggestive of Paget-Schroetter disease.
Physical Examination
Common physical examination findings of Paget-Schroetter disease include edema, tenderness, and dilated veins over the involved upper limb.
Laboratory Findings
Paget-Schroetter disease is not diagnosed based on laboratory findings since except D-dimer, other laboratory values are commonly normal.
Electrocardiogram
X-ray
There are no specific chest x-ray findings associated with Paget-Schroetter disease.
Echocardiography and Ultrasound
CT scan
Computed tomography (CT) is useful in the presence of atypical symptoms or in the setting of a normal ultrasound in a highly suspected patient.
MRI
Magnetic resonance imaging (MRI) is useful in the presence of atypical symptoms or in the setting of a normal ultrasound in a highly suspected patient.
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Interventions
Surgery
Based on pathophysiology of the Paget-Schroetter disease, extrinsic compression and endothelial damage to the vein are among the underlying problems that should be addressed. While thrombolysis only treats acute symptoms, correction surgery decreases recurrence in patients with suspected subclavian vein entrapment. Correction surgery involves both thoracic outlet decompression and restoration of vein patency.
Primary Prevention
There are no established measures for the primary prevention of Paget-Schroetter disease.
Secondary Prevention
There are no established measures for the secondary prevention of Paget-Schroetter disease.