HIV associated nephropathy causes: Difference between revisions
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{{HIV associated nephropathy}} | {{HIV associated nephropathy}} | ||
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==Overview== | ==Overview== | ||
Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy. | Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy. High risk alleles G1 (a missense mutation) and G2 (a frameshift deletion) for Apolipoprotein 1 (APOL1) are associated with HIVAN (APOL1 gene is on chromosome 22). | ||
==Causes== | ==Causes== | ||
Revision as of 16:08, 29 June 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2];Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]Shakiba Hassanzadeh, MD[4]
Overview
Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy. High risk alleles G1 (a missense mutation) and G2 (a frameshift deletion) for Apolipoprotein 1 (APOL1) are associated with HIVAN (APOL1 gene is on chromosome 22).
Causes
Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy.[1] Another cause for HIV-associated nephropathy is the lack of a deletion mutation of CCR5 or CCR2, which is protective form HIV-1 infection.[2]
Other factors that are attributed to the development of HIV-associated nephropathy is the use of intravenous drugs, however, this is inconclusive as patients with HIV-associated nephropathy are not all intravenous drug users.[3][4][5]
High risk alleles G1 (a missense mutation) and G2 (a frameshift deletion) for Apolipoprotein 1 (APOL1) are associated with HIVAN (APOL1 gene is on chromosome 22).[6]
References
- ↑ Klotman PE (1999). "HIV-associated nephropathy". Kidney Int. 56 (3): 1161–76. doi:10.1046/j.1523-1755.1999.00748.x. PMID 10469389.
- ↑ Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R; et al. (1996). "Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection". Cell. 86 (3): 367–77. PMID 8756719.
- ↑ Pardo V, Meneses R, Ossa L, Jaffe DJ, Strauss J, Roth D; et al. (1987). "AIDS-related glomerulopathy: occurrence in specific risk groups". Kidney Int. 31 (5): 1167–73. PMID 3599656.
- ↑ Klotman PE (1999). "HIV-associated nephropathy". Kidney Int. 56 (3): 1161–76. doi:10.1046/j.1523-1755.1999.00748.x. PMID 10469389.
- ↑ Rao TK, Friedman EA, Nicastri AD (1987). "The types of renal disease in the acquired immunodeficiency syndrome". N Engl J Med. 316 (17): 1062–8. doi:10.1056/NEJM198704233161705. PMID 3561458.
- ↑ Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P; et al. (2011). "APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy". J Am Soc Nephrol. 22 (11): 2129–37. doi:10.1681/ASN.2011040388. PMC 3231787. PMID 21997394.