C4 glomerulopathy other diagnostic studies: Difference between revisions
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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
A kidney biopsy may be helpful in the diagnosis of C4 glomerulopathy. Findings suggestive of C4 glomerulopathy include: | |||
*Membranoproliferative glomerulonephritis, with mesangial and endocapillary hypercellularity. | |||
*The glomerular capillary walls thickening. | |||
*Periodic acid–Schiff stain finding of ribbonlike material on the glomerular basement membrane. | |||
*Immunofluorescence microscopy indicates no glomerular staining for IgA, IgM, IgG, C3, C1q, kappa or lambda light chains. | |||
*Electron microscopy is favorable for large subendothelial osmiophilic dense deposits lining the glomerular basement membrane. | |||
*C4d glomerular staining help as a marker for immune complex-mediated glomerulonephritis. | |||
*Positive C4d can also assist as a marker for glomerulopathy resulting from activation of the Lectin pathway. | |||
==References== | ==References== | ||
Revision as of 05:26, 31 July 2020
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C4 glomerulopathy Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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C4 glomerulopathy other diagnostic studies On the Web |
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American Roentgen Ray Society Images of C4 glomerulopathy other diagnostic studies |
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Risk calculators and risk factors for C4 glomerulopathy other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
Other Diagnostic Studies
A kidney biopsy may be helpful in the diagnosis of C4 glomerulopathy. Findings suggestive of C4 glomerulopathy include:
- Membranoproliferative glomerulonephritis, with mesangial and endocapillary hypercellularity.
- The glomerular capillary walls thickening.
- Periodic acid–Schiff stain finding of ribbonlike material on the glomerular basement membrane.
- Immunofluorescence microscopy indicates no glomerular staining for IgA, IgM, IgG, C3, C1q, kappa or lambda light chains.
- Electron microscopy is favorable for large subendothelial osmiophilic dense deposits lining the glomerular basement membrane.
- C4d glomerular staining help as a marker for immune complex-mediated glomerulonephritis.
- Positive C4d can also assist as a marker for glomerulopathy resulting from activation of the Lectin pathway.