Reperfusion injury natural history: Difference between revisions
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'''Editors-In-Chief:''' {{AC}}; [[C. Michael Gibson]], M.S., M.D. [mailto:Mgibson@perfuse.org]; [[User:Shivam Singla|Dr. Shivam Singla M.D. [2]]] '''Associate Editors-In-Chief: '''[[User:Kashish Goel|Kashish Goel, M.D ;]] | '''Editors-In-Chief:''' {{AC}}; [[C. Michael Gibson]], M.S., M.D. [mailto:Mgibson@perfuse.org]; [[User:Shivam Singla|Dr. Shivam Singla M.D. [2]]] '''Associate Editors-In-Chief: '''[[User:Kashish Goel|Kashish Goel, M.D ;]] | ||
==Complications== | ==Complications== | ||
[[File:IRI Complications.jpg|thumb|342x342px|Complications of IRI]][[Myocardial stunning]]: Delayed recovery, usually 2-3 days, of the viable myocardium after reperfusion is termed as "myocardial stunning". It is mainly due to the release of reactive oxygen species and intracellular calcium overload.<ref name=" | [[File:IRI Complications.jpg|thumb|342x342px|Complications of IRI]][[Myocardial stunning]]: Delayed recovery, usually 2-3 days, of the viable myocardium after reperfusion is termed as "myocardial stunning". It is mainly due to the release of reactive oxygen species and intracellular calcium overload.<ref name="urlIschemia-Reperfusion injury complications - Bing images">{{cite web |url=https://www.bing.com/images/search?view=detailV2&ccid=FVMGxeuC&id=46BC612E1794659190F717CC3D3F77FEA36EF682&thid=OIP.FVMGxeuC8zH6i0vvnMy5DQHaEK&mediaurl=https%3A%2F%2Fimage.slidesharecdn.com%2Facutelimbischemia-180511172855%2F95%2Facute-limb-ischemia-51-638.jpg%3Fcb%3D1526059810&exph=359&expw=638&q=Ischemia-Reperfusion+injury+complications&simid=607995390083465719&ck=6E892C76C2A35E2105D8D39D53AF9A4A&selectedindex=77&form=EX0023&ajaxhist=0&vt=0&sim=11&adlt=demote&shtp=GetUrl&shid=a24fc5c2-7301-4e27-b1d9-896e2696dbff&shtk=QWN1dGUgbGltYiBpc2NoZW1pYQ%3D%3D&shdk=Rm91bmQgb24gQmluZyBmcm9tIHd3dy5zbGlkZXNoYXJlLm5ldA%3D%3D&shhk=OBfVCGL5rkfN4vWBSfFD%2BUgMUh1wps950XqW6CH0l0Y%3D&shth=OSH.Y3HRJbt0m5Ahco1JO15MhA |title=Ischemia-Reperfusion injury complications - Bing images |format= |work= |accessdate=}}</ref> | ||
* [[Myocardial infarction]]: Irreversible myocyte cell death secondary to reduced oxygen delivery for more than 20-30 minutes, will lead to infarction. Reperfusion helps prevent complete loss of the involved area, however oxidative stress due to this may prevent complete resolution. | * [[Myocardial infarction]]: Irreversible myocyte cell death secondary to reduced oxygen delivery for more than 20-30 minutes, will lead to infarction. Reperfusion helps prevent complete loss of the involved area, however oxidative stress due to this may prevent complete resolution. | ||
Revision as of 03:25, 13 August 2020
Editors-In-Chief: Anjan K. Chakrabarti, M.D. [1]; C. Michael Gibson, M.S., M.D. [2]; Dr. Shivam Singla M.D. [2] Associate Editors-In-Chief: Kashish Goel, M.D ;
Complications
Myocardial stunning: Delayed recovery, usually 2-3 days, of the viable myocardium after reperfusion is termed as "myocardial stunning". It is mainly due to the release of reactive oxygen species and intracellular calcium overload.[1]
- Myocardial infarction: Irreversible myocyte cell death secondary to reduced oxygen delivery for more than 20-30 minutes, will lead to infarction. Reperfusion helps prevent complete loss of the involved area, however oxidative stress due to this may prevent complete resolution.
- Acute heart failure: Loss of myocardial contractility and systolic dysfunction associated with ischemia/reperfusion injury may lead to development of acute heart failure. Early reperfusion in the course of STEMI prevents myocardial necrosis and may lead to complete recovery of function.
- Ventricular arrhythmias: Reperfusion of the blocked coronary artery can also precipitate arrhythmias ranging from ventricular premature beats to life-threatening ventricular fibrillation.
