Non-bacterial thrombotic endocarditis history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
*The majority of patients with non-bacterial thrombotic endocarditis are asymptomatic<ref name="urlNonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment - el‐Shami - 2007 - The Oncologist - Wiley Online Library">{{cite web |url=+https://doi.org/10.1634/theoncologist.12-5-518 |title=Nonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment - el‐Shami - 2007 - The Oncologist - Wiley Online Library |format= |work= |accessdate=}}</ref>. | *The majority of patients with non-bacterial thrombotic endocarditis are asymptomatic<ref name="urlNonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment - el‐Shami - 2007 - The Oncologist - Wiley Online Library">{{cite web |url=+https://doi.org/10.1634/theoncologist.12-5-518 |title=Nonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment - el‐Shami - 2007 - The Oncologist - Wiley Online Library |format= |work= |accessdate=}}</ref>. | ||
*Systemic embolism of the brain, liver, or spleen is a common initial clinical manifestation of NBTE, and occur in more than half of patients<ref name="pmid9217593">{{cite journal |vauthors=Edoute Y, Haim N, Rinkevich D, Brenner B, Reisner SA |title=Cardiac valvular vegetations in cancer patients: a prospective echocardiographic study of 200 patients |journal=Am. J. Med. |volume=102 |issue=3 |pages=252–8 |date=March 1997 |pmid=9217593 |doi=10.1016/S0002-9343(96)00457-3 |url=}}</ref><ref name="pmid17522239">{{cite journal |vauthors=el-Shami K, Griffiths E, Streiff M |title=Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment |journal=Oncologist |volume=12 |issue=5 |pages=518–23 |date=May 2007 |pmid=17522239 |doi=10.1634/theoncologist.12-5-518 |url=}}</ref>. | *Systemic embolism of the brain, liver, or spleen is a common initial clinical manifestation of NBTE, and occur in more than half of patients<ref name="pmid9217593">{{cite journal |vauthors=Edoute Y, Haim N, Rinkevich D, Brenner B, Reisner SA |title=Cardiac valvular vegetations in cancer patients: a prospective echocardiographic study of 200 patients |journal=Am. J. Med. |volume=102 |issue=3 |pages=252–8 |date=March 1997 |pmid=9217593 |doi=10.1016/S0002-9343(96)00457-3 |url=}}</ref><ref name="pmid17522239">{{cite journal |vauthors=el-Shami K, Griffiths E, Streiff M |title=Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment |journal=Oncologist |volume=12 |issue=5 |pages=518–23 |date=May 2007 |pmid=17522239 |doi=10.1634/theoncologist.12-5-518 |url=}}</ref><ref name="urlInfective endocarditis | The BMJ">{{cite web |url=https://www.bmj.com/content/333/7563/334 |title=Infective endocarditis | The BMJ |format= |work= |accessdate=}}</ref>. | ||
*The most common presentation of NBTE is a sudden stroke<ref name="pmid3965856">{{cite journal |vauthors=Graus F, Rogers LR, Posner JB |title=Cerebrovascular complications in patients with cancer |journal=Medicine (Baltimore) |volume=64 |issue=1 |pages=16–35 |date=January 1985 |pmid=3965856 |doi=10.1097/00005792-198501000-00002 |url=}}</ref>. | *The most common presentation of NBTE is a sudden stroke<ref name="pmid3965856">{{cite journal |vauthors=Graus F, Rogers LR, Posner JB |title=Cerebrovascular complications in patients with cancer |journal=Medicine (Baltimore) |volume=64 |issue=1 |pages=16–35 |date=January 1985 |pmid=3965856 |doi=10.1097/00005792-198501000-00002 |url=}}</ref>. | ||
*About 50% of patients with NBTE present with new or a change in existing cardiac murmurs. | *About 50% of patients with NBTE present with new or a change in existing cardiac murmurs. | ||
Revision as of 16:15, 16 August 2020
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non-bacterial thrombotic endocarditis |
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Differentiating non-bacterial thrombotic endocarditis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aisha Adigun, B.Sc., M.D.[2]
Overview
The majority of patients with [disease name] are asymptomatic.
OR
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History and Symptoms
- The majority of patients with non-bacterial thrombotic endocarditis are asymptomatic[1].
- Systemic embolism of the brain, liver, or spleen is a common initial clinical manifestation of NBTE, and occur in more than half of patients[2][3][4].
- The most common presentation of NBTE is a sudden stroke[5].
- About 50% of patients with NBTE present with new or a change in existing cardiac murmurs.
- Murmurs are usually non-specific systolic murmurs commonly located in the left lower sternal border[6].
- Valvular deficiency or heart failure is an uncommon initial presentation[7].
History
Patients with NBTE may have a positive history of:
- Malignancy
- Disseminated intravascular coagulation
- Antiphospholipid syndrome
- Autoimmune disease such as systemic lupus erythematosus
Common Symptoms
In alphabetical order, some of the common manifestations and symptoms of NTBE include:
- Cerebrovascular embolism
- Amnesia
- Delirium
- Dysphagia
- Dysphasia
- Dysarthria
- Localized/diffuse weakness
- Localized/diffuse numbness
- Psychomotor agitation
- Seizures
- Vision loss
- Heart failure secondary to defective valves
- Chest pain
- Dyspnea
- Lethargy
- Orthopnea
- Paroxysmal nocturnal dyspnea
- Peripheral edema
- Symptoms due to underlying SLE;
- Arthritis
- Hematuria
- Rash
- Sweating
- Fatigue
- Systemic thromboembolism
- Acute abdominal syndromes;
- Flank pain due to kidney infarction
- Nausea
- Pain
- Vomiting
- Raynaud's phenomenon due to embolization to the skin
- Acute abdominal syndromes;
Less Common Symptoms
In alphabetical order, some of the less common manifestations and symptoms of NBTE include;
- Secondary infective endocarditis
- Chest pain
- Fever
- Night sweats
- Weightloss
References
- ↑ [+https://doi.org/10.1634/theoncologist.12-5-518 "Nonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment - el‐Shami - 2007 - The Oncologist - Wiley Online Library"] Check
|url=value (help). - ↑ Edoute Y, Haim N, Rinkevich D, Brenner B, Reisner SA (March 1997). "Cardiac valvular vegetations in cancer patients: a prospective echocardiographic study of 200 patients". Am. J. Med. 102 (3): 252–8. doi:10.1016/S0002-9343(96)00457-3. PMID 9217593.
- ↑ el-Shami K, Griffiths E, Streiff M (May 2007). "Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment". Oncologist. 12 (5): 518–23. doi:10.1634/theoncologist.12-5-518. PMID 17522239.
- ↑ "Infective endocarditis | The BMJ".
- ↑ Graus F, Rogers LR, Posner JB (January 1985). "Cerebrovascular complications in patients with cancer". Medicine (Baltimore). 64 (1): 16–35. doi:10.1097/00005792-198501000-00002. PMID 3965856.
- ↑ Rosen P, Armstrong D (January 1973). "Nonbacterial thrombotic endocarditis in patients with malignant neoplastic diseases". Am. J. Med. 54 (1): 23–9. doi:10.1016/0002-9343(73)90079-x. PMID 4682494.
- ↑ Mazokopakis EE, Syros PK, Starakis IK (June 2010). "Nonbacterial thrombotic endocarditis (marantic endocarditis) in cancer patients". Cardiovasc Hematol Disord Drug Targets. 10 (2): 84–6. doi:10.2174/187152910791292484. PMID 20397972.