Burn epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
The incidence/prevalence of burn injury is approximately '''86% of''' sustained burns/ scald(thermal) injuries, 4%sustained electrical burn injuries, and 3%remaining Are chemical. <ref name="urlijmedph.org">{{cite web |url=http://ijmedph.org/sites/default/files/IntJMedPubHealth-10-2-54.pdf |title=ijmedph.org |format= |work= |accessdate=}}</ref><ref name="pmid2012">Stamm O, Latscha U, Janecek P, Campana A (1976) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=2012 Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp.] ''Am J Obstet Gynecol'' 124 (2):193-5. [http://dx.doi.org/10.1016/s0002-9378(16)33297-5 DOI:10.1016/s0002-9378(16)33297-5] PMID: [https://pubmed.gov/Lancet . 2012 Dec 15;380(9859):2095-128. doi: 10.1 Lancet . 2012 Dec 15;380(9859):2095-128. doi: 10.1]</ref><ref name="urlBurn Evaluation And Management - StatPearls - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK430741/ |title=Burn Evaluation And Management - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | The [[Incidence (epidemiology)|incidence]][[/prevalence]] of [[Burn (injury)|burn]] injury is approximately '''86% of''' sustained [[burns]]/ [[scald]] (thermal) injuries, 4%sustained [[Electrical burns|electrical]] burn injuries, and 3%remaining Are [[chemical]]. <ref name="urlijmedph.org">{{cite web |url=http://ijmedph.org/sites/default/files/IntJMedPubHealth-10-2-54.pdf |title=ijmedph.org |format= |work= |accessdate=}}</ref><ref name="pmid2012">Stamm O, Latscha U, Janecek P, Campana A (1976) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=2012 Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp.] ''Am J Obstet Gynecol'' 124 (2):193-5. [http://dx.doi.org/10.1016/s0002-9378(16)33297-5 DOI:10.1016/s0002-9378(16)33297-5] PMID: [https://pubmed.gov/Lancet . 2012 Dec 15;380(9859):2095-128. doi: 10.1 Lancet . 2012 Dec 15;380(9859):2095-128. doi: 10.1]</ref><ref name="urlBurn Evaluation And Management - StatPearls - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK430741/ |title=Burn Evaluation And Management - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | ||
Patients of all age groups may develop burns injury, but flame and scale burns it’s commonly affects individuals Children and younger('''children younger than five years old are more often injured with scald burns)''' than/older(More '''adults are injured with flame burns ).''' it reported 122 case in this age.122 were aged between 16-35 yrs. 189 people who sustained burns/ scald injuries 33 were children aged 15 yrs or less <ref name="pmid27733281">GBD 2015 Mortality and Causes of Death Collaborators (2016) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=27733281 Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.] ''Lancet'' 388 (10053):1459-1544. [http://dx.doi.org/10.1016/S0140-6736(16)31012-1 DOI:10.1016/S0140-6736(16)31012-1] PMID: [https://pubmed.gov/PMID: 27733281 PMID: 27733281]</ref>. | Patients of all age groups may develop [[burns]] injury, but [[flame]] and [[Scale-inverse-chi-square distribution|scale]] burns it’s commonly affects individuals Children and younger('''children younger than five years old are more often injured with scald burns)''' than/older(More '''adults are injured with flame [[burns]] ).''' it reported 122 case in this age.122 were aged between 16-35 yrs. 189 people who sustained [[burns]]/ [[scald]] injuries 33 were children aged 15 yrs or less <ref name="pmid27733281">GBD 2015 Mortality and Causes of Death Collaborators (2016) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=27733281 Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.] ''Lancet'' 388 (10053):1459-1544. [http://dx.doi.org/10.1016/S0140-6736(16)31012-1 DOI:10.1016/S0140-6736(16)31012-1] PMID: [https://pubmed.gov/PMID: 27733281 PMID: 27733281]</ref>. | ||
There is no racial predilection to burn injury. | There is no [[racial]] predilection to [[Burn (injury)|burn]] injury. | ||
Female <ref name="RibeiroJacobsen2008">{{cite journal|last1=Ribeiro|first1=Priscila S.|last2=Jacobsen|first2=Kathryn H.|last3=Mathers|first3=Colin D.|last4=Garcia-Moreno|first4=Claudia|title=Priorities for women's health from the Global Burden of Disease study|journal=International Journal of Gynecology & Obstetrics|volume=102|issue=1|year=2008|pages=82–90|issn=00207292|doi=10.1016/j.ijgo.2008.01.025}}</ref>are more commonly affected by critical burn injury than male (>25% body surface area) was statistically significant in adults<ref name="pmid27733282">GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (2016) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=27733282 Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.] ''Lancet'' 388 (10053):1545-1602. [http://dx.doi.org/10.1016/S0140-6736(16)31678-6 DOI:10.1016/S0140-6736(16)31678-6] PMID: [https://pubmed.gov/PMID: 27733282 PMID: 27733282]</ref><ref name="HaagsmaGraetz2016">{{cite journal|last1=Haagsma|first1=Juanita A|last2=Graetz|first2=Nicholas|last3=Bolliger|first3=Ian|last4=Naghavi|first4=Mohsen|last5=Higashi|first5=Hideki|last6=Mullany|first6=Erin C|last7=Abera|first7=Semaw Ferede|last8=Abraham|first8=Jerry Puthenpurakal|last9=Adofo|first9=Koranteng|last10=Alsharif|first10=Ubai|last11=Ameh|first11=Emmanuel A|last12=Ammar|first12=Walid|last13=Antonio|first13=Carl Abelardo T|last14=Barrero|first14=Lope H|last15=Bekele|first15=Tolesa|last16=Bose|first16=Dipan|last17=Brazinova|first17=Alexandra|last18=Catalá-López|first18=Ferrán|last19=Dandona|first19=Lalit|last20=Dandona|first20=Rakhi|last21=Dargan|first21=Paul I|last22=De Leo|first22=Diego|last23=Degenhardt|first23=Louisa|last24=Derrett|first24=Sarah|last25=Dharmaratne|first25=Samath D|last26=Driscoll|first26=Tim R|last27=Duan|first27=Leilei|last28=Petrovich Ermakov|first28=Sergey|last29=Farzadfar|first29=Farshad|last30=Feigin|first30=Valery L|last31=Franklin|first31=Richard C|last32=Gabbe|first32=Belinda|last33=Gosselin|first33=Richard A|last34=Hafezi-Nejad|first34=Nima|last35=Hamadeh|first35=Randah Ribhi|last36=Hijar|first36=Martha|last37=Hu|first37=Guoqing|last38=Jayaraman|first38=Sudha P|last39=Jiang|first39=Guohong|last40=Khader|first40=Yousef Saleh|last41=Khan|first41=Ejaz Ahmad|last42=Krishnaswami|first42=Sanjay|last43=Kulkarni|first43=Chanda|last44=Lecky|first44=Fiona E|last45=Leung|first45=Ricky|last46=Lunevicius|first46=Raimundas|last47=Lyons|first47=Ronan Anthony|last48=Majdan|first48=Marek|last49=Mason-Jones|first49=Amanda J|last50=Matzopoulos|first50=Richard|last51=Meaney|first51=Peter A|last52=Mekonnen|first52=Wubegzier|last53=Miller|first53=Ted R|last54=Mock|first54=Charles N|last55=Norman|first55=Rosana E|last56=Orozco|first56=Ricardo|last57=Polinder|first57=Suzanne|last58=Pourmalek|first58=Farshad|last59=Rahimi-Movaghar|first59=Vafa|last60=Refaat|first60=Amany|last61=Rojas-Rueda|first61=David|last62=Roy|first62=Nobhojit|last63=Schwebel|first63=David C|last64=Shaheen|first64=Amira|last65=Shahraz|first65=Saeid|last66=Skirbekk|first66=Vegard|last67=Søreide|first67=Kjetil|last68=Soshnikov|first68=Sergey|last69=Stein|first69=Dan J|last70=Sykes|first70=Bryan L|last71=Tabb|first71=Karen M|last72=Temesgen|first72=Awoke Misganaw|last73=Tenkorang|first73=Eric Yeboah|last74=Theadom|first74=Alice M|last75=Tran|first75=Bach Xuan|last76=Vasankari|first76=Tommi J|last77=Vavilala|first77=Monica S|last78=Vlassov|first78=Vasiliy Victorovich|last79=Woldeyohannes|first79=Solomon Meseret|last80=Yip|first80=Paul|last81=Yonemoto|first81=Naohiro|last82=Younis|first82=Mustafa Z|last83=Yu|first83=Chuanhua|last84=Murray|first84=Christopher J L|last85=Vos|first85=Theo|last86=Balalla|first86=Shivanthi|last87=Phillips|first87=Michael R|title=The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013|journal=Injury Prevention|volume=22|issue=1|year=2016|pages=3–18|issn=1353-8047|doi=10.1136/injuryprev-2015-041616}}</ref><ref name="pmid23245604">Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V | display-authors=etal (2012) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=23245604 Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.] ''Lancet'' 380 (9859):2095-128. [http://dx.doi.org/10.1016/S0140-6736(12)61728-0 DOI:10.1016/S0140-6736(12)61728-0] PMID: [https://pubmed.gov/PMID: 23245604 DOI: 10.1016/S0140-6736(12)61728-0 PMID: 23245604 DOI: 10.1016/S0140-6736(12)61728-0]</ref> | [[Female]] <ref name="RibeiroJacobsen2008">{{cite journal|last1=Ribeiro|first1=Priscila S.|last2=Jacobsen|first2=Kathryn H.|last3=Mathers|first3=Colin D.|last4=Garcia-Moreno|first4=Claudia|title=Priorities for women's health from the Global Burden of Disease study|journal=International Journal of Gynecology & Obstetrics|volume=102|issue=1|year=2008|pages=82–90|issn=00207292|doi=10.1016/j.ijgo.2008.01.025}}</ref>are more commonly affected by critical [[Burn (injury)|burn]] injury than [[male]] (>25% body surface area) was statistically significant in [[adults]]<ref name="pmid27733282">GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (2016) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=27733282 Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.] ''Lancet'' 388 (10053):1545-1602. [http://dx.doi.org/10.1016/S0140-6736(16)31678-6 DOI:10.1016/S0140-6736(16)31678-6] PMID: [https://pubmed.gov/PMID: 27733282 PMID: 27733282]</ref><ref name="HaagsmaGraetz2016">{{cite journal|last1=Haagsma|first1=Juanita A|last2=Graetz|first2=Nicholas|last3=Bolliger|first3=Ian|last4=Naghavi|first4=Mohsen|last5=Higashi|first5=Hideki|last6=Mullany|first6=Erin C|last7=Abera|first7=Semaw Ferede|last8=Abraham|first8=Jerry Puthenpurakal|last9=Adofo|first9=Koranteng|last10=Alsharif|first10=Ubai|last11=Ameh|first11=Emmanuel A|last12=Ammar|first12=Walid|last13=Antonio|first13=Carl Abelardo T|last14=Barrero|first14=Lope H|last15=Bekele|first15=Tolesa|last16=Bose|first16=Dipan|last17=Brazinova|first17=Alexandra|last18=Catalá-López|first18=Ferrán|last19=Dandona|first19=Lalit|last20=Dandona|first20=Rakhi|last21=Dargan|first21=Paul I|last22=De Leo|first22=Diego|last23=Degenhardt|first23=Louisa|last24=Derrett|first24=Sarah|last25=Dharmaratne|first25=Samath D|last26=Driscoll|first26=Tim R|last27=Duan|first27=Leilei|last28=Petrovich Ermakov|first28=Sergey|last29=Farzadfar|first29=Farshad|last30=Feigin|first30=Valery L|last31=Franklin|first31=Richard C|last32=Gabbe|first32=Belinda|last33=Gosselin|first33=Richard A|last34=Hafezi-Nejad|first34=Nima|last35=Hamadeh|first35=Randah Ribhi|last36=Hijar|first36=Martha|last37=Hu|first37=Guoqing|last38=Jayaraman|first38=Sudha P|last39=Jiang|first39=Guohong|last40=Khader|first40=Yousef Saleh|last41=Khan|first41=Ejaz Ahmad|last42=Krishnaswami|first42=Sanjay|last43=Kulkarni|first43=Chanda|last44=Lecky|first44=Fiona E|last45=Leung|first45=Ricky|last46=Lunevicius|first46=Raimundas|last47=Lyons|first47=Ronan Anthony|last48=Majdan|first48=Marek|last49=Mason-Jones|first49=Amanda J|last50=Matzopoulos|first50=Richard|last51=Meaney|first51=Peter A|last52=Mekonnen|first52=Wubegzier|last53=Miller|first53=Ted R|last54=Mock|first54=Charles N|last55=Norman|first55=Rosana E|last56=Orozco|first56=Ricardo|last57=Polinder|first57=Suzanne|last58=Pourmalek|first58=Farshad|last59=Rahimi-Movaghar|first59=Vafa|last60=Refaat|first60=Amany|last61=Rojas-Rueda|first61=David|last62=Roy|first62=Nobhojit|last63=Schwebel|first63=David C|last64=Shaheen|first64=Amira|last65=Shahraz|first65=Saeid|last66=Skirbekk|first66=Vegard|last67=Søreide|first67=Kjetil|last68=Soshnikov|first68=Sergey|last69=Stein|first69=Dan J|last70=Sykes|first70=Bryan L|last71=Tabb|first71=Karen M|last72=Temesgen|first72=Awoke Misganaw|last73=Tenkorang|first73=Eric Yeboah|last74=Theadom|first74=Alice M|last75=Tran|first75=Bach Xuan|last76=Vasankari|first76=Tommi J|last77=Vavilala|first77=Monica S|last78=Vlassov|first78=Vasiliy Victorovich|last79=Woldeyohannes|first79=Solomon Meseret|last80=Yip|first80=Paul|last81=Yonemoto|first81=Naohiro|last82=Younis|first82=Mustafa Z|last83=Yu|first83=Chuanhua|last84=Murray|first84=Christopher J L|last85=Vos|first85=Theo|last86=Balalla|first86=Shivanthi|last87=Phillips|first87=Michael R|title=The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013|journal=Injury Prevention|volume=22|issue=1|year=2016|pages=3–18|issn=1353-8047|doi=10.1136/injuryprev-2015-041616}}</ref><ref name="pmid23245604">Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V | display-authors=etal (2012) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=23245604 Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.] ''Lancet'' 380 (9859):2095-128. [http://dx.doi.org/10.1016/S0140-6736(12)61728-0 DOI:10.1016/S0140-6736(12)61728-0] PMID: [https://pubmed.gov/PMID: 23245604 DOI: 10.1016/S0140-6736(12)61728-0 PMID: 23245604 DOI: 10.1016/S0140-6736(12)61728-0]</ref> | ||
{{cite book | last = Herndon | first = David | title = Total burn care | publisher = Saunders Elsevier | location = Edinburgh New York | year = 2012 | isbn = 978-1-4377-2786-9 }} | {{cite book | last = Herndon | first = David | title = Total burn care | publisher = Saunders Elsevier | location = Edinburgh New York | year = 2012 | isbn = 978-1-4377-2786-9 }} | ||
'''Burn injuries more commonly affect people of low and middle income and people in low-income countries'''<ref name="urlBurn Evaluation And Management - StatPearls - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK430741/ |title=Burn Evaluation And Management - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | '''[[Burn (injury)|Burn]] injuries more commonly affect people of low and middle income and people in low-income countries'''<ref name="urlBurn Evaluation And Management - StatPearls - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK430741/ |title=Burn Evaluation And Management - StatPearls - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | ||
==References== | ==References== |
Revision as of 08:07, 9 October 2020
Epidemiology and Demographics
The incidence/prevalence of burn injury is approximately 86% of sustained burns/ scald (thermal) injuries, 4%sustained electrical burn injuries, and 3%remaining Are chemical. [1][2][3]
Patients of all age groups may develop burns injury, but flame and scale burns it’s commonly affects individuals Children and younger(children younger than five years old are more often injured with scald burns) than/older(More adults are injured with flame burns ). it reported 122 case in this age.122 were aged between 16-35 yrs. 189 people who sustained burns/ scald injuries 33 were children aged 15 yrs or less [4].
There is no racial predilection to burn injury.
Female [5]are more commonly affected by critical burn injury than male (>25% body surface area) was statistically significant in adults[6][7][8]
Herndon, David (2012). Total burn care. Edinburgh New York: Saunders Elsevier. ISBN 978-1-4377-2786-9.
Burn injuries more commonly affect people of low and middle income and people in low-income countries[3]
References
- ↑ "ijmedph.org" (PDF).
- ↑ Stamm O, Latscha U, Janecek P, Campana A (1976) Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp. Am J Obstet Gynecol 124 (2):193-5. DOI:10.1016/s0002-9378(16)33297-5 PMID: . 2012 Dec 15;380(9859):2095-128. doi: 10.1 Lancet . 2012 Dec 15;380(9859):2095-128. doi: 10.1
- ↑ 3.0 3.1 "Burn Evaluation And Management - StatPearls - NCBI Bookshelf".
- ↑ GBD 2015 Mortality and Causes of Death Collaborators (2016) Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388 (10053):1459-1544. DOI:10.1016/S0140-6736(16)31012-1 PMID: 27733281 PMID: 27733281
- ↑ Ribeiro, Priscila S.; Jacobsen, Kathryn H.; Mathers, Colin D.; Garcia-Moreno, Claudia (2008). "Priorities for women's health from the Global Burden of Disease study". International Journal of Gynecology & Obstetrics. 102 (1): 82–90. doi:10.1016/j.ijgo.2008.01.025. ISSN 0020-7292.
- ↑ GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (2016) Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388 (10053):1545-1602. DOI:10.1016/S0140-6736(16)31678-6 PMID: 27733282 PMID: 27733282
- ↑ Haagsma, Juanita A; Graetz, Nicholas; Bolliger, Ian; Naghavi, Mohsen; Higashi, Hideki; Mullany, Erin C; Abera, Semaw Ferede; Abraham, Jerry Puthenpurakal; Adofo, Koranteng; Alsharif, Ubai; Ameh, Emmanuel A; Ammar, Walid; Antonio, Carl Abelardo T; Barrero, Lope H; Bekele, Tolesa; Bose, Dipan; Brazinova, Alexandra; Catalá-López, Ferrán; Dandona, Lalit; Dandona, Rakhi; Dargan, Paul I; De Leo, Diego; Degenhardt, Louisa; Derrett, Sarah; Dharmaratne, Samath D; Driscoll, Tim R; Duan, Leilei; Petrovich Ermakov, Sergey; Farzadfar, Farshad; Feigin, Valery L; Franklin, Richard C; Gabbe, Belinda; Gosselin, Richard A; Hafezi-Nejad, Nima; Hamadeh, Randah Ribhi; Hijar, Martha; Hu, Guoqing; Jayaraman, Sudha P; Jiang, Guohong; Khader, Yousef Saleh; Khan, Ejaz Ahmad; Krishnaswami, Sanjay; Kulkarni, Chanda; Lecky, Fiona E; Leung, Ricky; Lunevicius, Raimundas; Lyons, Ronan Anthony; Majdan, Marek; Mason-Jones, Amanda J; Matzopoulos, Richard; Meaney, Peter A; Mekonnen, Wubegzier; Miller, Ted R; Mock, Charles N; Norman, Rosana E; Orozco, Ricardo; Polinder, Suzanne; Pourmalek, Farshad; Rahimi-Movaghar, Vafa; Refaat, Amany; Rojas-Rueda, David; Roy, Nobhojit; Schwebel, David C; Shaheen, Amira; Shahraz, Saeid; Skirbekk, Vegard; Søreide, Kjetil; Soshnikov, Sergey; Stein, Dan J; Sykes, Bryan L; Tabb, Karen M; Temesgen, Awoke Misganaw; Tenkorang, Eric Yeboah; Theadom, Alice M; Tran, Bach Xuan; Vasankari, Tommi J; Vavilala, Monica S; Vlassov, Vasiliy Victorovich; Woldeyohannes, Solomon Meseret; Yip, Paul; Yonemoto, Naohiro; Younis, Mustafa Z; Yu, Chuanhua; Murray, Christopher J L; Vos, Theo; Balalla, Shivanthi; Phillips, Michael R (2016). "The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013". Injury Prevention. 22 (1): 3–18. doi:10.1136/injuryprev-2015-041616. ISSN 1353-8047.
- ↑ Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V | display-authors=etal (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380 (9859):2095-128. DOI:10.1016/S0140-6736(12)61728-0 PMID: 23245604 DOI: 10.1016/S0140-6736(12)61728-0 PMID: 23245604 DOI: 10.1016/S0140-6736(12)61728-0