Choledocholithiasis pathophysiology: Difference between revisions
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It is understood that the [[Bile]] is made in the [[liver]] and stored in the [[gallbladder]]. Concentrated [[bile]] from the [[gallbladder]] can lead to the formation of [[gallstone]]. The stone passes from the [[gallbladder]] to the cystic duct, then into the [[Bile duct|common bile duct]] (CBD), and block the CBD. <ref > https://jamanetwork.com/journals/jama/fullarticle/2706140</ref> | It is understood that the [[Bile]] is made in the [[liver]] and stored in the [[gallbladder]]. Concentrated [[bile]] from the [[gallbladder]] can lead to the formation of [[gallstone]]. The stone passes from the [[gallbladder]] to the cystic duct, then into the [[Bile duct|common bile duct]] (CBD), and block the CBD. <ref > https://jamanetwork.com/journals/jama/fullarticle/2706140</ref> | ||
Primary Choledocholithiasis is formed from stones within the bile duct that occur due to bile stasis in the CBD, forming an intraductal stone. The cause of [[bile duct]] stasis includes [[bile duct]] dilatation with increasing [[age]]. Less commonly, bile stasis can result from complications from [[Mirizzi Syndrome]] or hepatolithiasis (gallstone in the biliary duct of the liver). The obstructed flow of the [[bile duct]] leads to obstructive [[jaundice]] and possibly [[hepatitis]]. The stagnant [[Bile]] can lead to [[infection]] and [[inflammation]] of the [[bile duct]], causing [[bactibilia]] and ascending [[cholangitis]]. If the blockage is at the common [[bile duct]] after the [[pancreatic duct]], join the CBD, it can become inflamed, with autoactivation of pancreatic enzymes leading to gallstone pancreatitis. Choledocholithiasis can also be secondary to [[cholelithiasis]] and choledochoduodenal-fistula stricture. choledochoduodenal-fistula is an abnormal opening in choledochus and the duodenum and a rare complication of chronic duodenal ulcer with [[ | Primary Choledocholithiasis is formed from stones within the bile duct that occur due to bile stasis in the CBD, forming an intraductal stone. The cause of [[bile duct]] stasis includes [[bile duct]] dilatation with increasing [[age]]. Less commonly, bile stasis can result from complications from [[Mirizzi Syndrome]] or hepatolithiasis (gallstone in the biliary duct of the liver). The obstructed flow of the [[bile duct]] leads to obstructive [[jaundice]] and possibly [[hepatitis]]. The stagnant [[Bile]] can lead to [[infection]] and [[inflammation]] of the [[bile duct]], causing [[bactibilia]] and ascending [[cholangitis]]. If the blockage is at the common [[bile duct]] after the [[pancreatic duct]], join the CBD, it can become inflamed, with autoactivation of pancreatic enzymes leading to gallstone pancreatitis. Choledocholithiasis can also be secondary to [[cholelithiasis]] and choledochoduodenal-fistula stricture. choledochoduodenal-fistula is an abnormal opening in choledochus and the duodenum and a rare complication of chronic duodenal ulcer with [[cholelithiasis]] | ||
<ref> https://www.merckmanuals.com/professional/hepatic-and-biliary-disorders/gallbladder-and-bile-duct-disorders/choledocholithiasis-and-cholangitis | <ref> https://www.merckmanuals.com/professional/hepatic-and-biliary-disorders/gallbladder-and-bile-duct-disorders/choledocholithiasis-and-cholangitis | ||
Revision as of 16:36, 2 November 2020
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Choledocholithiasis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Adenike Eketunde
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Overview
It is thought that Choledocholithiasis is the result of gallstone produced either in the gall bladder or bile duct obstructing the common bile duct.
Pathophysiology
It is understood that the Bile is made in the liver and stored in the gallbladder. Concentrated bile from the gallbladder can lead to the formation of gallstone. The stone passes from the gallbladder to the cystic duct, then into the common bile duct (CBD), and block the CBD. [1]
Primary Choledocholithiasis is formed from stones within the bile duct that occur due to bile stasis in the CBD, forming an intraductal stone. The cause of bile duct stasis includes bile duct dilatation with increasing age. Less commonly, bile stasis can result from complications from Mirizzi Syndrome or hepatolithiasis (gallstone in the biliary duct of the liver). The obstructed flow of the bile duct leads to obstructive jaundice and possibly hepatitis. The stagnant Bile can lead to infection and inflammation of the bile duct, causing bactibilia and ascending cholangitis. If the blockage is at the common bile duct after the pancreatic duct, join the CBD, it can become inflamed, with autoactivation of pancreatic enzymes leading to gallstone pancreatitis. Choledocholithiasis can also be secondary to cholelithiasis and choledochoduodenal-fistula stricture. choledochoduodenal-fistula is an abnormal opening in choledochus and the duodenum and a rare complication of chronic duodenal ulcer with cholelithiasis
References
- ↑ https://jamanetwork.com/journals/jama/fullarticle/2706140
- ↑ https://www.merckmanuals.com/professional/hepatic-and-biliary-disorders/gallbladder-and-bile-duct-disorders/choledocholithiasis-and-cholangitis https://radiopaedia.org/articles/recurrent-pyogenic-cholangiohepatitis-1?lang=us
- ↑ B S B, Kar A, Dutta M, Mandal A, De Bakshi S (2017). "A case of choledochoduodenal fistula - an unusual case report". Clin Case Rep. 5 (9): 1462–1464. doi:10.1002/ccr3.991. PMC 5582229. PMID 28878904.
- ↑ https://journals.lww.com/ajg/Fulltext/2018/10001/Secondary_Multiple_Choledocholithiasis_in.2161.aspx?__cf_chl_jschl_tk__=8dbf6b78ccc27338b4f6be5657b6a51776ee5f37-1604332386-0-AcuXzQIt4c1HaCWBf9hSa3EHuEWWQi-LLdalnwICEz7desYL-RQVMp2l3T_TSL6XxnuG_LURfZMwYF3rNQlyCOqoSDr0QNDuEx7lh6xagxBosv92m2RHHr2CT01qFwG_Xhhpk0IJxYah9rLukVRKsAlWqBVMiWmx2lhCUGDuh47qCLnkJ4NojmmXwLgxMzQwdT3WyCIpNut7OBJB9mLOQg0eOSl_fFwVE582N78ro5yq8Wh5zRgQ5Y2Oh5KiEtFSf79dhyRgnxyrbrv1-uEj0IMJs0N12UqzOQ2uSwXuC4PXR-299SH8luxtGeIflx-bZoEk1zXoKOAkJoopLnUCBmF8MPgkj7uCrempA51vz2TL91NQ1T4L_ualXqWWt6_PWdB8jg2hVNRW0T44RWCyKhd18FOkyOVUERCGhrrHETVMHzliqZMIpsZY8IihYuG7cQ