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Polycythemia vera was first mentioned in 1892 in the medical literature by a French physician Louis Henri Vaquez.
Polycythemia vera was first mentioned in 1892 in the medical literature by a French physician Louis Henri Vaquez.


*The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
In 1899 and 1900 two additional cases of polycythemia vera were described by Richard Clark Cabot both with increased erythrocytes and leukocytes and one with marked splenomegaly.
*In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
In 1951, William Dameshek grouped together chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, primary myelofibrosis, and erythroleukemia and coined the term "myeloproliferative disorders".
*In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
In 2005, a gain of function mutation in JAK2 (JAK2V617F) was first implicated in the pathogenesis of BCR-ABL negative myeloproliferative disorders.


===Landmark Events in the Development of Treatment Strategies===
===Landmark Events in the Development of Treatment Strategies===

Revision as of 03:26, 3 December 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]

Overview

Historical Perspective

Discovery

Polycythemia vera was first mentioned in 1892 in the medical literature by a French physician Louis Henri Vaquez.

In 1899 and 1900 two additional cases of polycythemia vera were described by Richard Clark Cabot both with increased erythrocytes and leukocytes and one with marked splenomegaly. In 1951, William Dameshek grouped together chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, primary myelofibrosis, and erythroleukemia and coined the term "myeloproliferative disorders". In 2005, a gain of function mutation in JAK2 (JAK2V617F) was first implicated in the pathogenesis of BCR-ABL negative myeloproliferative disorders.

Landmark Events in the Development of Treatment Strategies

Impact on Cultural History

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The following are a few famous cases of [disease name]:

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