Polycythemia causes: Difference between revisions
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==Overview== | ==Overview== | ||
*Divided into primary and secondary causes based on underlying genetic mutations and other factors(refer to classification). | *Divided into primary and secondary causes based on underlying genetic mutations and other factors(refer to classification). | ||
*Primary erythrocytosis | *Primary erythrocytosis | ||
- Polycythemia vera | - Polycythemia vera | ||
*Secondary erythrocytosis | *Secondary erythrocytosis | ||
- Congenital: | - Congenital: | ||
- Erythropoietin receptor-mediated | - Erythropoietin receptor-mediated | ||
| Line 44: | Line 47: | ||
- EPO administration | - EPO administration | ||
- Androgen administration | - Androgen administration | ||
- Idiopathic erythrocytosis <ref name=" | - Idiopathic erythrocytosis <ref name="McMULLIN2008">{{cite journal|last1=McMULLIN|first1=M. F.|title=The classification and diagnosis of erythrocytosis|journal=International Journal of Laboratory Hematology|year=2008|issn=17515521|doi=10.1111/j.1751-553X.2008.01102.x}}</ref> <ref name="pmid967201">{{cite journal |vauthors=Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L |title=Polycythemia vera: stem-cell and probable clonal origin of the disease |journal=N Engl J Med |volume=295 |issue=17 |pages=913–6 |date=October 1976 |pmid=967201 |doi=10.1056/NEJM197610212951702 |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 21:26, 1 March 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
- Divided into primary and secondary causes based on underlying genetic mutations and other factors(refer to classification).
- Primary erythrocytosis
- Polycythemia vera
- Secondary erythrocytosis
- Congenital:
- Erythropoietin receptor-mediated
- High oxygen affinity hemoglobin
- Bisphosphoglycerate mutase deficiency
- VHL (Von Hippel-Lindau) gene mutation (Chuvash erythrocytosis)
- PHD2 mutations
- HIF-2 alpha mutations
- Acquired:
- Hypoxia driven
- Central hypoxic process:
- Chronic Lung disease
- Right-to-left cardiopulmonary vascular shunts
- Carbon monoxide poisoning
- Smoker's erythrocytosis
- Hypoventilation syndromes including sleep apnea (high-altitude habitat)
- Local renal hypoxia:
- Renal Artery Stenosis
- End-Stage Renal Disease
- Hydronephrosis
- Renal cysts (polycystic kidney disease)
- Postrenal transplant erythrocytosis
- Pathologic EPO production:
- Tumors
- Cerebellar hemangioblastoma
- Meningioma
- Parathyroid carcinoma/adenomas
- Hepatocellular carcinoma
- Renal cell cancer
- Pheochromocytoma
- Uterine leiomyomas
- Exogenous EPO:
- Drug associated
- EPO administration
- Androgen administration
- Idiopathic erythrocytosis [1] [2]
References
- ↑ McMULLIN, M. F. (2008). "The classification and diagnosis of erythrocytosis". International Journal of Laboratory Hematology. doi:10.1111/j.1751-553X.2008.01102.x. ISSN 1751-5521.
- ↑ Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L (October 1976). "Polycythemia vera: stem-cell and probable clonal origin of the disease". N Engl J Med. 295 (17): 913–6. doi:10.1056/NEJM197610212951702. PMID 967201.