Polycythemia risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
*One of the most common and most dangerous complications of [[polycythemia vera]] is [[thrombus]] formation. The risk factors are as follows: | *One of the most common and most dangerous [[complications]] of [[polycythemia vera]] is [[thrombus]] formation. The risk factors are as follows: | ||
*Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis. | *Women- usually younger at the time of [[diagnosis]], have a higher risk of arterio-venous [[thrombosis]]. | ||
*Mutation- the higher burden of JAK2V617F allele | *[[Mutation]]- the higher burden of JAK2V617F [[allele]] | ||
*Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis | *[[Inflammatory]] markers- [[Pentraxins]] play an important role: increased hs-[[CRP]] and a lower [[PTX3]] have a higher risk of [[thrombosis]]. | ||
*Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly | *Presence of microparticles- responsible for decreased [[thrombin]] inhibition, increased CD41, and an increased chance of [[splenomegaly]]. | ||
*Neutrophil Extracellular Trap formations- NETosis and apoptosis <ref name="url[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM">{{cite web |url=https://www.dovepress.com/polycythemia-vera-associated-complications-pathogenesis-clinical-manif-peer-reviewed-fulltext-article-JBM |title=[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM |format= |work= |accessdate=}}</ref> | *[[Neutrophil]] Extracellular Trap formations- NETosis and [[apoptosis]].<ref name="url[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM">{{cite web |url=https://www.dovepress.com/polycythemia-vera-associated-complications-pathogenesis-clinical-manif-peer-reviewed-fulltext-article-JBM |title=[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM |format= |work= |accessdate=}}</ref> | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
There are no established risk factors for developing polycythemia vera except for the genetic abnormality JAK2V617F.
Risk Factors
- One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows:
- Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis.
- Mutation- the higher burden of JAK2V617F allele
- Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis.
- Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly.
- Neutrophil Extracellular Trap formations- NETosis and apoptosis.[1]