Polycythemia risk factors: Difference between revisions

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Revision as of 17:16, 2 March 2021

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S [2]

There are no established risk factors for developing polycythemia vera except for the genetic abnormality JAK2V617F.

One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows:
Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis.
Mutation- the higher burden of JAK2V617F allele
Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis.
Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly.
Neutrophil Extracellular Trap formations- NETosis and apoptosis.

@@ Line 13: / Line 13: @@
 *[[Inflammatory]] markers- [[Pentraxins]] play an important role: increased hs-[[CRP]] and a lower [[PTX3]] have a higher risk of [[thrombosis]].
 *Presence of microparticles- responsible for decreased [[thrombin]] inhibition, increased CD41, and an increased chance of [[splenomegaly]].
-*[[Neutrophil]] Extracellular Trap formations- NETosis and [[apoptosis]].<ref name="url[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM">{{cite web |url=https://www.dovepress.com/polycythemia-vera-associated-complications-pathogenesis-clinical-manif-peer-reviewed-fulltext-article-JBM |title=[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man &#124; JBM |format= |work= |accessdate=}}</ref>
+*[[Neutrophil]] Extracellular Trap formations- NETosis and [[apoptosis]].
 ==References==