Acrodermatitis chronica atrophicans laboratory findings: Difference between revisions
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*[[Physicians]] can use [[serology|serologic]] and [[histology|histologic]] examination to confirm the [[diagnosis]] of [[acrodermatitis chronica atrophicans]]. | *[[Physicians]] can use [[serology|serologic]] and [[histology|histologic]] examination to confirm the [[diagnosis]] of [[acrodermatitis chronica atrophicans]]. | ||
*High anti-[[Spirochaete|spirochetal]] [[antibody]] levels has been detected at indirect [[immunofluorescence]] and [[enzyme linked immunosorbent assay (ELISA)]].<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | *High anti-[[Spirochaete|spirochetal]] [[antibody]] levels has been detected at indirect [[immunofluorescence]] and [[enzyme linked immunosorbent assay (ELISA)]].<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | ||
*Among various [[antigens]] in [[borrelia burgdorferi]], [[flagellum]] [[antigen]] is one of the recommended [[serology|serologic evaluation]] in [[acrodermatitis chronica atrophicans]] [[patients]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | |||
*A study done on [[patients]] with [[acrodermatitis chronica atrophicans]] revealed [[rheumatoid factor]] in 32% of [[patients]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | *A study done on [[patients]] with [[acrodermatitis chronica atrophicans]] revealed [[rheumatoid factor]] in 32% of [[patients]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | ||
*[[Biopsy]] shows [[inflammation#Chronic inflammation|chronic inflammatory]] signs in [[Chronic (medical)|chronic cases]]. Other histological finding are listed below: <ref name="pmid22153213">{{cite journal |author=Rosenlund S, Bækgaard N, Menné T |title=[Acrodermatitis chronica atrophicans can be difficult to diagnose] |language=Danish |journal=Ugeskr. Laeg. |volume=173 |issue=50 |pages=3272–3 |year=2011 |month=December |pmid=22153213 |doi= |url=}}</ref><ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref> | *[[Biopsy]] shows [[inflammation#Chronic inflammation|chronic inflammatory]] signs in [[Chronic (medical)|chronic cases]]. Other histological finding are listed below: <ref name="pmid22153213">{{cite journal |author=Rosenlund S, Bækgaard N, Menné T |title=[Acrodermatitis chronica atrophicans can be difficult to diagnose] |language=Danish |journal=Ugeskr. Laeg. |volume=173 |issue=50 |pages=3272–3 |year=2011 |month=December |pmid=22153213 |doi= |url=}}</ref><ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref> | ||
Revision as of 12:22, 5 June 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2] Raviteja Guddeti, M.B.B.S. [3]
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Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of acrodermatitis chronica atrophicans.
Laboratory Findings
- Physicians can use serologic and histologic examination to confirm the diagnosis of acrodermatitis chronica atrophicans.
- High anti-spirochetal antibody levels has been detected at indirect immunofluorescence and enzyme linked immunosorbent assay (ELISA).[1][2]
- Among various antigens in borrelia burgdorferi, flagellum antigen is one of the recommended serologic evaluation in acrodermatitis chronica atrophicans patients.[2]
- A study done on patients with acrodermatitis chronica atrophicans revealed rheumatoid factor in 32% of patients.[2]
- Biopsy shows chronic inflammatory signs in chronic cases. Other histological finding are listed below: [3][1]
References
- ↑ 1.0 1.1 Asbrink E, Hovmark A, Olsson I (1986). "Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients". Zentralbl Bakteriol Mikrobiol Hyg A. 263 (1–2): 253–61. doi:10.1016/s0176-6724(86)80128-6. PMID 3577484.
- ↑ 2.0 2.1 2.2 Hansen K, Asbrink E (1989). "Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay". J Clin Microbiol. 27 (3): 545–51. doi:10.1128/jcm.27.3.545-551.1989. PMC 267355. PMID 2715325.
- ↑ Rosenlund S, Bækgaard N, Menné T (2011). "[Acrodermatitis chronica atrophicans can be difficult to diagnose]". Ugeskr. Laeg. (in Danish). 173 (50): 3272–3. PMID 22153213. Unknown parameter
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