Acrodermatitis chronica atrophicans laboratory findings: Difference between revisions
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*[[Physicians]] can use [[serology|serologic]] and [[histology|histologic]] examination to confirm the [[diagnosis]] of [[acrodermatitis chronica atrophicans]]. | *[[Physicians]] can use [[serology|serologic]] and [[histology|histologic]] examination to confirm the [[diagnosis]] of [[acrodermatitis chronica atrophicans]]. | ||
*High anti-[[Spirochaete|spirochetal]] [[antibody]] levels has been detected at indirect [[immunofluorescence]] and [[enzyme linked immunosorbent assay (ELISA)]].<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | *High anti-[[Spirochaete|spirochetal]] [[antibody]] levels has been detected at indirect [[immunofluorescence]] and [[enzyme linked immunosorbent assay (ELISA)]].<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | ||
*Among various [[antigens]] in [[borrelia burgdorferi]], [[flagellum]] [[antigen]] is one of the recommended [[serology|serologic evaluation]] in [[acrodermatitis chronica atrophicans]] [[patients]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | *Among various [[antigens]] in [[borrelia burgdorferi]], [[flagellum]] [[antigen]] is one of the recommended [[serology|serologic evaluation]] in [[acrodermatitis chronica atrophicans]] [[patients]]. Moreover checking [[Immunoglobulin G|IgG]] against [[borrelia burgdorferi|borrelia]] are more specific compared to [[Immunoglobulin M|IgM]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | ||
*A study done on [[patients]] with [[acrodermatitis chronica atrophicans]] revealed [[rheumatoid factor]] in 32% of [[patients]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | *A study done on [[patients]] with [[acrodermatitis chronica atrophicans]] revealed [[rheumatoid factor]] in 32% of [[patients]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | ||
*[[Biopsy]] shows [[inflammation#Chronic inflammation|chronic inflammatory]] signs in [[Chronic (medical)|chronic cases]]. Other histological finding are listed below: <ref name="pmid22153213">{{cite journal |author=Rosenlund S, Bækgaard N, Menné T |title=[Acrodermatitis chronica atrophicans can be difficult to diagnose] |language=Danish |journal=Ugeskr. Laeg. |volume=173 |issue=50 |pages=3272–3 |year=2011 |month=December |pmid=22153213 |doi= |url=}}</ref><ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref> | *[[Biopsy]] shows [[inflammation#Chronic inflammation|chronic inflammatory]] signs in [[Chronic (medical)|chronic cases]]. Other histological finding are listed below: <ref name="pmid22153213">{{cite journal |author=Rosenlund S, Bækgaard N, Menné T |title=[Acrodermatitis chronica atrophicans can be difficult to diagnose] |language=Danish |journal=Ugeskr. Laeg. |volume=173 |issue=50 |pages=3272–3 |year=2011 |month=December |pmid=22153213 |doi= |url=}}</ref><ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref> | ||
Revision as of 12:33, 5 June 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2] Raviteja Guddeti, M.B.B.S. [3]
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Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of acrodermatitis chronica atrophicans.
Laboratory Findings
- Physicians can use serologic and histologic examination to confirm the diagnosis of acrodermatitis chronica atrophicans.
- High anti-spirochetal antibody levels has been detected at indirect immunofluorescence and enzyme linked immunosorbent assay (ELISA).[1][2]
- Among various antigens in borrelia burgdorferi, flagellum antigen is one of the recommended serologic evaluation in acrodermatitis chronica atrophicans patients. Moreover checking IgG against borrelia are more specific compared to IgM.[2]
- A study done on patients with acrodermatitis chronica atrophicans revealed rheumatoid factor in 32% of patients.[2]
- Biopsy shows chronic inflammatory signs in chronic cases. Other histological finding are listed below: [3][1]
References
- ↑ 1.0 1.1 Asbrink E, Hovmark A, Olsson I (1986). "Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients". Zentralbl Bakteriol Mikrobiol Hyg A. 263 (1–2): 253–61. doi:10.1016/s0176-6724(86)80128-6. PMID 3577484.
- ↑ 2.0 2.1 2.2 Hansen K, Asbrink E (1989). "Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay". J Clin Microbiol. 27 (3): 545–51. doi:10.1128/jcm.27.3.545-551.1989. PMC 267355. PMID 2715325.
- ↑ Rosenlund S, Bækgaard N, Menné T (2011). "[Acrodermatitis chronica atrophicans can be difficult to diagnose]". Ugeskr. Laeg. (in Danish). 173 (50): 3272–3. PMID 22153213. Unknown parameter
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