Lactic acidosis classification: Difference between revisions
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==Classification== | ==Classification== | ||
The Cohen-Woods classification (1976) categorizes causes of lactic acidosis as follows: | The Cohen-Woods classification (1976) categorizes causes of lactic acidosis as follows: | ||
*Type A: Decreased perfusion or oxygenation: Occurs due to an oxygen demand/supply mismatch, causing [[Glycolysis|anaerobic glycolysis]]. Examples include all shock states ([[Septic Shock|septic]], [[Cardiogenic shock|cardiogenic]], [[Hypovolemic shock|hypovolemic]], [[Obstructive shock|obstructive]]), regional ischemia (limb, mesenteric), seizures/convulsions, and severe cases of shivering. | |||
*Type B: Defined as not having to do with tissue hypoxia or hypoperfusion. | |||
**B1: Underlying diseases (sometimes causing type A) such as liver disease, malignancy, [[HIV AIDS|HIV]], [[thiamine deficiency]], [[Diabetic ketoacidosis|diabetic ketoacidosis.]] | |||
**B2: Medication or intoxication example [[metformin]], [[epinephrine]], [[total parenteral nutrition]], [[ethanol]]. | |||
**B3: [[Inborn error of metabolism]], such as [[mitochondrial myopathy]], congenital lactic acidosis. | |||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 07:06, 18 July 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Classification
The Cohen-Woods classification (1976) categorizes causes of lactic acidosis as follows:
- Type A: Decreased perfusion or oxygenation: Occurs due to an oxygen demand/supply mismatch, causing anaerobic glycolysis. Examples include all shock states (septic, cardiogenic, hypovolemic, obstructive), regional ischemia (limb, mesenteric), seizures/convulsions, and severe cases of shivering.
- Type B: Defined as not having to do with tissue hypoxia or hypoperfusion.
- B1: Underlying diseases (sometimes causing type A) such as liver disease, malignancy, HIV, thiamine deficiency, diabetic ketoacidosis.
- B2: Medication or intoxication example metformin, epinephrine, total parenteral nutrition, ethanol.
- B3: Inborn error of metabolism, such as mitochondrial myopathy, congenital lactic acidosis.