Acute disseminated encephalomyelitis epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
==Incidence== | ===Incidence=== | ||
*The [[Incidence (epidemiology)|Incidence]] of [[Acute disseminated encephalomyelitis causes|Acute disseminated encephalomyelitis]] is about 1 in 125,000-250,000 people each year, in children younger than 10 years, despite the fact that it is a rare disorder.<ref name="pmid11376179">{{cite journal| author=Hynson JL, Kornberg AJ, Coleman LT, Shield L, Harvey AS, Kean MJ| title=Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. | journal=Neurology | year= 2001 | volume= 56 | issue= 10 | pages= 1308-12 | pmid=11376179 | doi=10.1212/wnl.56.10.1308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11376179 }}</ref><ref name="pmid12165620">{{cite journal| author=Murthy SN, Faden HS, Cohen ME, Bakshi R| title=Acute disseminated encephalomyelitis in children. | journal=Pediatrics | year= 2002 | volume= 110 | issue= 2 Pt 1 | pages= e21 | pmid=12165620 | doi=10.1542/peds.110.2.e21 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12165620 }}</ref> | *The [[Incidence (epidemiology)|Incidence]] of [[Acute disseminated encephalomyelitis causes|Acute disseminated encephalomyelitis]] is about 1 in 125,000-250,000 people each year, in children younger than 10 years, despite the fact that it is a rare disorder.<ref name="pmid11376179">{{cite journal| author=Hynson JL, Kornberg AJ, Coleman LT, Shield L, Harvey AS, Kean MJ| title=Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. | journal=Neurology | year= 2001 | volume= 56 | issue= 10 | pages= 1308-12 | pmid=11376179 | doi=10.1212/wnl.56.10.1308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11376179 }}</ref><ref name="pmid12165620">{{cite journal| author=Murthy SN, Faden HS, Cohen ME, Bakshi R| title=Acute disseminated encephalomyelitis in children. | journal=Pediatrics | year= 2002 | volume= 110 | issue= 2 Pt 1 | pages= e21 | pmid=12165620 | doi=10.1542/peds.110.2.e21 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12165620 }}</ref> | ||
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*The prevalance of [[Acute disseminated encephalomyelitis causes|Acute disseminated encephalomyelitis]] rises as one moves further away from the Equator.<nowiki><ref name="pmid27742816"></nowiki>{{cite journal| author=Yamaguchi Y, Torisu H, Kira R, Ishizaki Y, Sakai Y, Sanefuji M | display-authors=etal| title=A nationwide survey of pediatric acquired demyelinating syndromes in Japan. | journal=Neurology | year= 2016 | volume= 87 | issue= 19 | pages= 2006-2015 | pmid=27742816 | doi=10.1212/WNL.0000000000003318 | pmc=5109945 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27742816 }}</ref><ref name="pmid25761377">{{cite journal| author=Koelman DL, Mateen FJ| title=Acute disseminated encephalomyelitis: current controversies in diagnosis and outcome. | journal=J Neurol | year= 2015 | volume= 262 | issue= 9 | pages= 2013-24 | pmid=25761377 | doi=10.1007/s00415-015-7694-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25761377 }}*Majority are categorized as post-[[infectious]] [[central nervous system]] illness ([[viral]] or [[Bacterial|bacteria]]<nowiki/>l) being recorded in up to 50–75 percent of patients and the minority being after [[vaccination]].</ref><ref name="pmid26620160">{{cite journal| author=Berzero G, Cortese A, Ravaglia S, Marchioni E| title=Diagnosis and therapy of acute disseminated encephalomyelitis and its variants. | journal=Expert Rev Neurother | year= 2016 | volume= 16 | issue= 1 | pages= 83-101 | pmid=26620160 | doi=10.1586/14737175.2015.1126510 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26620160 }}</ref> | *The prevalance of [[Acute disseminated encephalomyelitis causes|Acute disseminated encephalomyelitis]] rises as one moves further away from the Equator.<nowiki><ref name="pmid27742816"></nowiki>{{cite journal| author=Yamaguchi Y, Torisu H, Kira R, Ishizaki Y, Sakai Y, Sanefuji M | display-authors=etal| title=A nationwide survey of pediatric acquired demyelinating syndromes in Japan. | journal=Neurology | year= 2016 | volume= 87 | issue= 19 | pages= 2006-2015 | pmid=27742816 | doi=10.1212/WNL.0000000000003318 | pmc=5109945 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27742816 }}</ref><ref name="pmid25761377">{{cite journal| author=Koelman DL, Mateen FJ| title=Acute disseminated encephalomyelitis: current controversies in diagnosis and outcome. | journal=J Neurol | year= 2015 | volume= 262 | issue= 9 | pages= 2013-24 | pmid=25761377 | doi=10.1007/s00415-015-7694-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25761377 }}*Majority are categorized as post-[[infectious]] [[central nervous system]] illness ([[viral]] or [[Bacterial|bacteria]]<nowiki/>l) being recorded in up to 50–75 percent of patients and the minority being after [[vaccination]].</ref><ref name="pmid26620160">{{cite journal| author=Berzero G, Cortese A, Ravaglia S, Marchioni E| title=Diagnosis and therapy of acute disseminated encephalomyelitis and its variants. | journal=Expert Rev Neurother | year= 2016 | volume= 16 | issue= 1 | pages= 83-101 | pmid=26620160 | doi=10.1586/14737175.2015.1126510 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26620160 }}</ref> | ||
=== Prevalence === | |||
* The Prevalence of Acute disseminated encephalomyelitis rises as one moves further away from the equator | |||
===Case-fatality rate/Mortality rate=== | ===Case-fatality rate/Mortality rate=== | ||
Revision as of 03:28, 28 July 2021
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Overview
Epidemiology and Demographics
Incidence
- The Incidence of Acute disseminated encephalomyelitis is about 1 in 125,000-250,000 people each year, in children younger than 10 years, despite the fact that it is a rare disorder.[1][2]
- Each year, regional medical centers in the United States, the United Kingdom, and Australia see three to six instances.[3][4][5]
Prevalence
- The Prevalence of Acute disseminated encephalomyelitis rises as one moves further away from the equator
Case-fatality rate/Mortality rate
- Although Acute disseminated encephalomyelitis is potentially lethal, the mortality rate is none to low, but few studies found that mortality was around 3%.[6][7][8][9]
Age
- The usual age of onset is 3 to 7 years, few cases been reported between 10 and twenty.
Gender
- Acute disseminated encephalomyelitis affects males more likely than females (male to female ratio of 1.3:1), and it happens more frequently in the winter and spring.
Race
- There is no racial predilection to the development of Acute disseminated encephalomyelitis and affects people all over the world.[10]
Region
- It affects people all over the world, comparable to the geographic distribution of Multiple sclerosis.
References
- ↑ Hynson JL, Kornberg AJ, Coleman LT, Shield L, Harvey AS, Kean MJ (2001). "Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children". Neurology. 56 (10): 1308–12. doi:10.1212/wnl.56.10.1308. PMID 11376179.
- ↑ Murthy SN, Faden HS, Cohen ME, Bakshi R (2002). "Acute disseminated encephalomyelitis in children". Pediatrics. 110 (2 Pt 1): e21. doi:10.1542/peds.110.2.e21. PMID 12165620.
- ↑ {{cite journal| author=Dale RC, de Sousa C, Chong WK, Cox TC, Harding B, Neville BG| title=Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children.
Prevalence
- The prevalance of Acute disseminated encephalomyelitis rises as one moves further away from the Equator.<ref name="pmid27742816">Yamaguchi Y, Torisu H, Kira R, Ishizaki Y, Sakai Y, Sanefuji M; et al. (2016). "A nationwide survey of pediatric acquired demyelinating syndromes in Japan". Neurology. 87 (19): 2006–2015. doi:10.1212/WNL.0000000000003318. PMC 5109945. PMID 27742816.
- ↑ Koelman DL, Mateen FJ (2015). "Acute disseminated encephalomyelitis: current controversies in diagnosis and outcome". J Neurol. 262 (9): 2013–24. doi:10.1007/s00415-015-7694-7. PMID 25761377.*Majority are categorized as post-infectious central nervous system illness (viral or bacterial) being recorded in up to 50–75 percent of patients and the minority being after vaccination.
- ↑ Berzero G, Cortese A, Ravaglia S, Marchioni E (2016). "Diagnosis and therapy of acute disseminated encephalomyelitis and its variants". Expert Rev Neurother. 16 (1): 83–101. doi:10.1586/14737175.2015.1126510. PMID 26620160.
- ↑ Absoud M, Lim MJ, Chong WK, De Goede CG, Foster K, Gunny R; et al. (2013). "Paediatric acquired demyelinating syndromes: incidence, clinical and magnetic resonance imaging features". Mult Scler. 19 (1): 76–86. doi:10.1177/1352458512445944. PMC 3409874. PMID 22516794.
- ↑ Iype M, Kunju PAM, Saradakutty G, Anish TS, Sreedharan M, Ahamed SM (2017). "Short term outcome of ADEM: Results from a retrospective cohort study from South India". Mult Scler Relat Disord. 18: 128–134. doi:10.1016/j.msard.2017.09.018. PMID 29141794.
- ↑ Hennes EM, Baumann M, Schanda K, Anlar B, Bajer-Kornek B, Blaschek A; et al. (2017). "Prognostic relevance of MOG antibodies in children with an acquired demyelinating syndrome". Neurology. 89 (9): 900–908. doi:10.1212/WNL.0000000000004312. PMID 28768844.
- ↑ Absoud M, Parslow RC, Wassmer E, Hemingway C, Duncan HP, Cummins C; et al. (2011). "Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study". Mult Scler. 17 (10): 1258–61. doi:10.1177/1352458510382554. PMID 20876155.
- ↑ Pellegrino P, Radice S, Clementi E (2014). "Geoepidemiology of acute disseminated encephalomyelitis". Epidemiology. 25 (6): 928–9. doi:10.1097/EDE.0000000000000176. PMID 25265138.