Adrenal atrophy laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
The labs include random [[cortisol]], serum [[ACTH]], [[aldosterone]] and [[renin]], [[potassium]] and [[sodium]], [[ACTH stimulation test]] and | The labs include random [[cortisol]], serum [[ACTH]], [[aldosterone]] and [[renin]], [[potassium]] and [[sodium]], [[ACTH stimulation test]] and CRH stimulation test. | ||
==Laboratory findings== | ==Laboratory findings== | ||
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*[[Aldosterone]] and [[renin]]. | *[[Aldosterone]] and [[renin]]. | ||
*[[Potassium]] and [[sodium]]. | *[[Potassium]] and [[sodium]]. | ||
However, in order to check the functionality of the | However, in order to check the functionality of the Hypothalamic Pituitary Adrenal Axis the entire axis must be tested by [[ACTH stimulation test]] and CRH stimulation test. | ||
The ACTH stimulation test consists of injecting a small amount of synthetic ACTH, and the amount of cortisol (and sometimes aldosterone) that the adrenals produce in response is then measured.<ref name="pmid10084558">{{cite journal |vauthors=Abdu TA, Elhadd TA, Neary R, Clayton RN |title=Comparison of the low dose short synacthen test (1 microg), the conventional dose short synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease |journal=J Clin Endocrinol Metab |volume=84 |issue=3 |pages=838–43 |date=March 1999 |pmid=10084558 |doi=10.1210/jcem.84.3.5535 |url=}}</ref><ref name="pmid19382991">{{cite journal |vauthors=Husebye ES, Perheentupa J, Rautemaa R, Kämpe O |title=Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I |journal=J Intern Med |volume=265 |issue=5 |pages=514–29 |date=May 2009 |pmid=19382991 |doi=10.1111/j.1365-2796.2009.02090.x |url=}}</ref> | The ACTH stimulation test consists of injecting a small amount of synthetic ACTH, and the amount of cortisol (and sometimes aldosterone) that the adrenals produce in response is then measured.<ref name="pmid10084558">{{cite journal |vauthors=Abdu TA, Elhadd TA, Neary R, Clayton RN |title=Comparison of the low dose short synacthen test (1 microg), the conventional dose short synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease |journal=J Clin Endocrinol Metab |volume=84 |issue=3 |pages=838–43 |date=March 1999 |pmid=10084558 |doi=10.1210/jcem.84.3.5535 |url=}}</ref><ref name="pmid19382991">{{cite journal |vauthors=Husebye ES, Perheentupa J, Rautemaa R, Kämpe O |title=Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I |journal=J Intern Med |volume=265 |issue=5 |pages=514–29 |date=May 2009 |pmid=19382991 |doi=10.1111/j.1365-2796.2009.02090.x |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
The labs include random cortisol, serum ACTH, aldosterone and renin, potassium and sodium, ACTH stimulation test and CRH stimulation test.
Laboratory findings
The labs to be run should include:
However, in order to check the functionality of the Hypothalamic Pituitary Adrenal Axis the entire axis must be tested by ACTH stimulation test and CRH stimulation test. The ACTH stimulation test consists of injecting a small amount of synthetic ACTH, and the amount of cortisol (and sometimes aldosterone) that the adrenals produce in response is then measured.[1][2]
References
- ↑ Abdu TA, Elhadd TA, Neary R, Clayton RN (March 1999). "Comparison of the low dose short synacthen test (1 microg), the conventional dose short synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease". J Clin Endocrinol Metab. 84 (3): 838–43. doi:10.1210/jcem.84.3.5535. PMID 10084558.
- ↑ Husebye ES, Perheentupa J, Rautemaa R, Kämpe O (May 2009). "Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I". J Intern Med. 265 (5): 514–29. doi:10.1111/j.1365-2796.2009.02090.x. PMID 19382991.