Dysfunctional uterine bleeding pathophysiology: Difference between revisions
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{{Dysfunctional uterine bleeding}} | {{Dysfunctional uterine bleeding}} | ||
Editor-In-Chief: C. Michael Gibson, M.S., M.D. Associate Editor(s)-in-Chief: Arooj Naz | |||
==Overview== | |||
Dysfunctional uterine bleeding is a condition that affects many women worldwide, especially because it has a wide range of underlying causes. | |||
==Pathophysiology== | |||
<ref name="pmid30422508">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume= | issue= | pages= | pmid=30422508 | doi= | pmc= | url= }} </ref> | |||
Dysfunctional uterine bleeding can be classified into acute and chronic causes. | |||
# Acute Dysfunctional uterine bleeding | |||
* Acute bleeding can develop in one of two ways. Either bleeding can develop acutely on which immediate intervention is required to prevent excessive blood loss, or it can be imposed upon chronic uterine bleeding. The latter often refers to menstrual irregularities that developed of 6 months or longer. | |||
# Chronic Dysfunctional uterine bleeding | |||
* At the end of the menstrual cycle, progesterone levels fall significantly leading to a breakdown of the functional layer of the endometrium. This leads to the phenomenon known as the menstrual cycle. This cycle can become irregular due to several causes, especially any derangements in the architectural structure of the endometrium. Common underlying causes include polyps, adenomyosis, leiomyoma, malignancy or hyperplasia, coagulopathies, ovulatory dysfunction, endometrial disorders and iatrogenic causes. DUB that is due to underlying ovulatory causes occurs due to defects in local endometrial functions whereas anovulatory is often due to systemic disorders, endocrine or neurological imbalances. By understanding the pathophysiology of these conditions, one can understand the cause of dysfunctional uterine bleeding.<ref name="pmid11547028">{{cite journal| author=Munro MG| title=Dysfunctional uterine bleeding: advances in diagnosis and treatment. | journal=Curr Opin Obstet Gynecol | year= 2001 | volume= 13 | issue= 5 | pages= 475-89 | pmid=11547028 | doi=10.1097/00001703-200110000-00006 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11547028 }} </ref> | |||
'''Polyp''' | |||
'''Adenomyosis''' | |||
'''Leiomyoma''' | |||
'''Malignancy and hyperplasia''' | |||
'''Coagulopathy''' | |||
'''Ovulatory dysfunction''' | |||
'''Endometrial disorders''' | |||
'''Iatrogenic''' | |||
'''Ovulatory''' | |||
'''Anovulatory''' | |||
===Blood supply of Endometrium=== | |||
==References== | ==References== | ||
Revision as of 06:58, 2 March 2022
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Differentiating Dysfunctional uterine bleeding from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. Associate Editor(s)-in-Chief: Arooj Naz
Overview
Dysfunctional uterine bleeding is a condition that affects many women worldwide, especially because it has a wide range of underlying causes.
Pathophysiology
[1] Dysfunctional uterine bleeding can be classified into acute and chronic causes.
- Acute Dysfunctional uterine bleeding
- Acute bleeding can develop in one of two ways. Either bleeding can develop acutely on which immediate intervention is required to prevent excessive blood loss, or it can be imposed upon chronic uterine bleeding. The latter often refers to menstrual irregularities that developed of 6 months or longer.
- Chronic Dysfunctional uterine bleeding
- At the end of the menstrual cycle, progesterone levels fall significantly leading to a breakdown of the functional layer of the endometrium. This leads to the phenomenon known as the menstrual cycle. This cycle can become irregular due to several causes, especially any derangements in the architectural structure of the endometrium. Common underlying causes include polyps, adenomyosis, leiomyoma, malignancy or hyperplasia, coagulopathies, ovulatory dysfunction, endometrial disorders and iatrogenic causes. DUB that is due to underlying ovulatory causes occurs due to defects in local endometrial functions whereas anovulatory is often due to systemic disorders, endocrine or neurological imbalances. By understanding the pathophysiology of these conditions, one can understand the cause of dysfunctional uterine bleeding.[2]
Polyp
Adenomyosis
Leiomyoma
Malignancy and hyperplasia
Coagulopathy
Ovulatory dysfunction
Endometrial disorders
Iatrogenic
Ovulatory
Anovulatory
Blood supply of Endometrium
References
- ↑ "StatPearls". 2022. PMID 30422508.
- ↑ Munro MG (2001). "Dysfunctional uterine bleeding: advances in diagnosis and treatment". Curr Opin Obstet Gynecol. 13 (5): 475–89. doi:10.1097/00001703-200110000-00006. PMID 11547028.