Eczema causes: Difference between revisions
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*Lack of [[filaggrin]] [[gene]] causes [[dry skin]] and impaired [[skin]] [[barrier]] [[function]]. <ref name=filaggrin>Palmer, C.N. ''et al.'' (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. ''Nature Genetics'' '''38'''(4), 441-6. PMID 16550169</ref> | *Lack of [[filaggrin]] [[gene]] causes [[dry skin]] and impaired [[skin]] [[barrier]] [[function]]. <ref name=filaggrin>Palmer, C.N. ''et al.'' (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. ''Nature Genetics'' '''38'''(4), 441-6. PMID 16550169</ref> | ||
*[[Brain-derived neurotrophic factor]] (BDNF) | *[[Substance P]] and [[Brain-derived neurotrophic factor]] (BDNF) are responsible for the [[pruritic]] sensation in [[eczema]]. <ref name="BBC-blood chemicals">{{cite news |author= |title= 'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities. |url= http://news.bbc.co.uk/2/hi/health/6962450.stm |date= 26 August 2007 |publisher=BBC News |accessdate=2007-10-16}}</ref> | ||
Revision as of 00:27, 26 May 2022
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Eczema Microchapters |
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Eczema On the Web |
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American Roentgen Ray Society Images of Eczema |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
Eczema could be due to a genetic problem, or a result of the adverse effect of certain medication.
Causes
- Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as, LEKTI, produced from the gene SPINK5.
- Netherton’s syndrome, a congenital condition presenting with erythroderma, food allergy, hay fever, asthma, and urticaria, results from the mutation of this gene. [1]
- Substance P and Brain-derived neurotrophic factor (BDNF) are responsible for the pruritic sensation in eczema. [3]
Common Medications with Eczema as the Adverse Drug Effect
- Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).
| Medication |
|---|
| Cidofovir |
| Flurbiprofen |
| Olaparib |
| Siltuximab |
| Sorafenib |
| Tiagabine |
References
- ↑ Walley AJ, Chavanas S, Moffatt MF; et al. (2001Mutations in this gene are known to cause). "Gene polymorphism in Netherton and common atopic disease". Nat. Genet. 29 (2): 175–8. doi:10.1038/ng728. PMID 11544479. Check date values in:
|year=(help) - ↑ Palmer, C.N. et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics 38(4), 441-6. PMID 16550169
- ↑ "'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities". BBC News. 26 August 2007. Retrieved 2007-10-16.