Eczema pathophysiology: Difference between revisions
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* There are two main theories on the existence of [[atopic dermatitis]], also known as [[atopic eczema]] - the ''inside-out hypothesis'', and the ''outside-in hypothesis''. | * There are two main theories on the existence of [[atopic dermatitis]], also known as [[atopic eczema]] - the ''inside-out hypothesis'', and the ''outside-in hypothesis''. | ||
* ''Inside-out hypothesis'' | * ''Inside-out hypothesis'' | ||
** This hypothesis denotes that some [[allergic triggers]] weaken the [[skin]] barrier that leads to more introduction of [[allergens]] to the area, causing more [[inflammatory reaction]]. <ref name="pmid26761930">{{cite journal| author=Silverberg NB, Silverberg JI| title=Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis? | journal=Cutis | year= 2015 | volume= 96 | issue= 6 | pages= 359-61 | pmid=26761930 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26761930 }} </ref> | ** This hypothesis denotes that some [[allergic triggers]] weaken the [[skin]] barrier that leads to more introduction of [[allergens]] to the area, causing more [[inflammatory reaction]].<ref name="pmid26761930">{{cite journal| author=Silverberg NB, Silverberg JI| title=Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis? | journal=Cutis | year= 2015 | volume= 96 | issue= 6 | pages= 359-61 | pmid=26761930 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26761930 }} </ref> | ||
* ''Outside-in hypothesis'' | * ''Outside-in hypothesis'' | ||
** This hypothesis suggests that an impairment of the [[skin]] barrier should occur first before the onset of [[atopic dermatitis]]. | ** This hypothesis suggests that an impairment of the [[skin]] barrier should occur first before the onset of [[atopic dermatitis]]. | ||
Revision as of 20:14, 26 May 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
There are two main theories on the existence of atopic dermatitis, also known as atopic eczema - the inside-out hypothesis, and the outside-in hypothesis. [1]
Pathophysiology
- There are two main theories on the existence of atopic dermatitis, also known as atopic eczema - the inside-out hypothesis, and the outside-in hypothesis.
- Inside-out hypothesis
- This hypothesis denotes that some allergic triggers weaken the skin barrier that leads to more introduction of allergens to the area, causing more inflammatory reaction.[1]
- Outside-in hypothesis
- This hypothesis suggests that an impairment of the skin barrier should occur first before the onset of atopic dermatitis.
- This involves the down-regulation of filaggrin genes (FLG) responsible for maintenance of the proper function of skin barrier.[1] [2]
References
- ↑ 1.0 1.1 1.2 Silverberg NB, Silverberg JI (2015). "Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis?". Cutis. 96 (6): 359–61. PMID 26761930.
- ↑ Leung DY, Guttman-Yassky E (2014). "Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches". J Allergy Clin Immunol. 134 (4): 769–79. doi:10.1016/j.jaci.2014.08.008. PMC 4186710. PMID 25282559.