Eczema causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.

Overview

The etiology of eczema is multifactorial and complex. This involves aberrations in genetic component, adverse effect of certain medication and some environmental factors.

Etiology of Eczema

Genetic problem

• Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as, LEKTI, produced from the gene SPINK5.
• Lack of filaggrin gene causes dry skin.

Eczema as an adverse Drug Reaction

• Eczema can also be brought about by some adverse effects of medications.
• Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).

Table 1. More Common types of Eczema.

Medication
Cidofovir
Flurbiprofen
Olaparib
Siltuximab
Sorafenib
Tiagabine