Antiplatelet drug

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

An antiplatelet drug is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. They are effective in the arterial circulation, where anticoagulants have little effect.

They are widely used in primary and secondary prevention of thrombotic cerebrovascular or cardiovascular disease.

The Most Important Antiplatelet Drugs

• COX-2 inhibitor / Cyclooxygenase inhibitors
  • Aspirin
• Phosphodiesterase inhibitors
  • Cilostazol (Pletal)
• Glycoprotein IIB/IIIA inhibitors (intravenous use only)
  • Abciximab (ReoPro)
  • Eptifibatide (Integrilin)
  • Tirofiban (Aggrastat)
  • Defibrotide
• P2Y₁₂ (Adenosine diphosphate receptors) inhibitors (thienopyridines)
  • Clopidogrel (Plavix)
  • Ticlopidine (Ticlid)
• P2Y₁₂ (Adenosine diphosphate receptors) inhibitors (non-thienopyridines) - third generation
  • Prasugrel
  • Cangrelor
  • Ticagrelor

Should drug selection be driven by genetic testing and platelet function testing?

Guided therapy (drug choice based on genetic testing and platelet function testing may improve outcomes.

See also

• Anticoagulant drug
• Thrombolytic drug
• Antiaggregants