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==Historical Perspective==
==Historical Perspective==
*[[Acute disseminated encephalomyelitis CT|Acute disseminated encephalomyelitis]] has experimental evidence suggests that both primary [[autoimmune]] responses and [[immunological]] responses triggered by infection may play a role in central nervous system inflammation and demyelination. Clinically and [[histopathological]]<nowiki/>ly, two animal models closely resemble.<ref name="Rivers Sprunt Berry pp. 39–53">{{cite journal | last=Rivers | first=Thomas M. | last2=Sprunt | first2=D. H. | last3=Berry | first3=G. P. | title=OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS | journal=Journal of Experimental Medicine | publisher=Rockefeller University Press | volume=58 | issue=1 | date=1933-07-01 | issn=1540-9538 | doi=10.1084/jem.58.1.39 | pages=39–53}}</ref><ref name="pmid164412">{{cite journal| author=Lipton HL| title=Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination. | journal=Infect Immun | year= 1975 | volume= 11 | issue= 5 | pages= 1147-55 | pmid=164412 | doi=10.1128/iai.11.5.1147-1155.1975 | pmc=415190 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=164412  }}</ref>
*To begin, experimental [[autoimmune]] [[encephalomyelitis]] (EAE) is commonly utilized to investigate the underlying disease processes, after [[immunization]] with [[Central nervous system]] homogenate or encephalitogenic [[myelin]] [[peptides]] emulsified in Freund complete [[adjuvant]]. [[Inflammatory]] [[demyelinating]] [[lesions]] can be seen [[histopathological]]<nowiki/>ly in the [[brain]]<nowiki/>s and [[spinal cord]]<nowiki/>s of affected animals.
*Theiler [[murine]] [[encephalomyelitis]], which was first utilized as an animal model in the 1930s, has been used to investigate [[infectious]] and parainfectious pathways that may play a role in disease etiology.
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References{{Reflist|2}}
References{{Reflist|2}}

Revision as of 14:16, 24 October 2022

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